The association of primary biliary cholangitis with platelet-derived growth factor and tumor necrosis factor-α

Objective: This study was designed to observe the expression of platelet-derived growth factor (PDGF) and tumor necrosis factor-α (TNF-α) in 32 patients with primary biliary cholangitis (PBC) and 22 healthy controls. The correlation between these two (PDGF and TNF-α) and PBC was analyzed. Methods: The expression of PDGF and TNF-α in the serum of PBC patients and healthy controls was detected by ELISA, and a correlation analysis was conducted. Results: The PDGF serum levels of PDGF was 4.21 ± 2.91 ng/L in the control group, and 1.09 ± 0.43 ng/L in the PBC groups, respectively, and the difference was highly statistically significant (p < 0.001). Furthermore, serum TNF-α level was 126.53 ± 67.79 pg/mL in the control group and 46.13 ± 17.05 pg/mL in the PBC groups, respectively, and the difference was extremely statistically significant (p < 0.001). These variables were compared between the two groups by independent sample t-test. p < 0.05 was considered statistically significant. Conclusions: The expression of PDGF and TNF-α significantly decreased in the PBC group. PDGF and TNF-α may be important expression regulators in PBC. Correspondence to: Chun-Hai Xu, Department of Infectious Diseases, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, Tel: +86 138 0455 0718, Fax: +86 0470832212, E-mail: chunhaixu_dr@163.com

[1]  G. Hirschfield,et al.  EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. , 2017, Journal of hepatology.

[2]  C. Allen,et al.  Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. , 2008, Journal of molecular and cellular cardiology.

[3]  William M. Lee,et al.  AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE Antimitochondrial Antibodies in Acute Liver Failure: Implications for Primary Biliary Cirrhosis , 2007 .

[4]  C. Corpechot,et al.  Geotherapeutics of primary biliary cirrhosis: Bright and sunny around the Mediterranean but still cloudy and foggy in the United Kingdom , 2007, Hepatology.

[5]  M. Wendl.  This is an Open Access article distribut... , 2007 .

[6]  F. Carrat,et al.  The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. , 2005, Gastroenterology.

[7]  T. I. Serova,et al.  [Cytokines in primary biliary cirrhosis (diagnostic and prognostic value)]. , 2004, Терапевтический архив.

[8]  E. Dickson,et al.  Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis. , 2002, Journal of gastroenterology and hepatology.

[9]  W. Kim,et al.  Variant forms of cholestatic diseases involving small bile ducts in adults , 2000, American Journal of Gastroenterology.

[10]  David E. J. Jones,et al.  Natural history of early primary biliary cirrhosis , 1996, The Lancet.

[11]  U. Spengler,et al.  T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation. , 1992, Journal of hepatology.

[12]  L. Eriksson,et al.  Decreased in vitro production of tumor necrosis factor in primary biliary cirrhosis patients. , 1992, Scandinavian journal of gastroenterology.

[13]  Y. Nakanuma,et al.  Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. , 1979, Gastroenterology.