Framework to Predict Bipolar Episodes - Sensor Fusion of Electrodermal Activity Heart Rate Variability Sleep Patterns

Patients suffering from Bipolar disorder (BD) experience repeated relapses of depressive and manic states. The extremity of this disorder can lead to many unpleasant events, even suicide attempts, which make early detection vital. Presently, the primary method for identifying these states is evaluation by psychiatrists based on patient’s self-reporting. However, ubiquitous use of mobile devices in combination with sensor fusion has the potential to provide a faster and convenient alternative mode of diagnosis to better manage the illness. This paper proposes a continuous, autonomous sensor fusion based monitoring framework to identify and predict state changes in patients suffering from bipolar disorder. Instead of relying on subjective self-reported data, the proposed system uses sensors to measure and collect, Heart Rate Variability, Quantity and Quality of sleep and Electrodermal activity data as predictors to discern between the two bipolar states. Using classification techniques along with a fusion algorithm, a prediction algorithm can be derived based on all the sensor modalities, gathered via a mobile application, is used to set alerts and visualize the information and results efficiently.

[1]  Sheri L. Johnson,et al.  Assessment Tools for Adult Bipolar Disorder. , 2009, Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association.

[2]  P. Melillo,et al.  Nonlinear Heart Rate Variability features for real-life stress detection. Case study: students under stress due to university examination , 2011, Biomedical engineering online.

[3]  J. Unützer,et al.  Health care utilization and costs among patients treated for bipolar disorder in an insured population. , 1999, Psychiatric services.

[4]  Enzo Pasquale Scilingo,et al.  Advances in Electrodermal Activity Processing with Applications for Mental Health , 2016, Springer International Publishing.

[5]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .

[6]  M. Benedek,et al.  A continuous measure of phasic electrodermal activity , 2010, Journal of Neuroscience Methods.

[8]  S. Waiblinger,et al.  Heart rate variability in dairy cows—influences of breed and milking system , 2005, Physiology & Behavior.

[9]  Dennis A. Revicki,et al.  Costs of Bipolar Disorder , 2012, PharmacoEconomics.

[10]  Mika P. Tarvainen,et al.  Kubios HRV - Heart rate variability analysis software , 2014, Comput. Methods Programs Biomed..

[11]  R. Baldessarini,et al.  Suicide risk and treatments for patients with bipolar disorder. , 2003, JAMA.

[12]  G. Simon Social and economic burden of mood disorders , 2003, Biological Psychiatry.

[13]  Enzo Pasquale Scilingo,et al.  On the deconvolution analysis of electrodermal activity in bipolar patients , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[14]  Mark Matthews,et al.  In the mood: engaging teenagers in psychotherapy using mobile phones , 2011, CHI.

[15]  Oscar Mayora-Ibarra,et al.  Smartphone-Based Recognition of States and State Changes in Bipolar Disorder Patients , 2015, IEEE Journal of Biomedical and Health Informatics.

[16]  Char-nie Chen Sleep, Depression and Antidepressants , 1979, British Journal of Psychiatry.

[17]  R. Kessler,et al.  Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. , 2011, Archives of general psychiatry.

[18]  M. Migliorini,et al.  Can home-monitoring of sleep predict depressive episodes in bipolar patients? , 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[19]  S. Dilsaver An estimate of the minimum economic burden of bipolar I and II disorders in the United States: 2009. , 2011, Journal of affective disorders.

[20]  Enzo Pasquale Scilingo,et al.  Predicting Mood Changes in Bipolar Disorder through Heartbeat Nonlinear Dynamics: a Preliminary Study , 2015, CinC.

[21]  Jakob E. Bardram,et al.  Designing mobile health technology for bipolar disorder: a field trial of the monarca system , 2013, CHI.

[22]  D J Kupfer,et al.  REM latency: a psychobiologic marker for primary depressive disease. , 1976, Biological psychiatry.

[23]  E. Saperova,et al.  State Anxiety and Nonlinear Dynamics of Heart Rate Variability in Students , 2016, PloS one.

[24]  A. Rush,et al.  Reduced rapid eye movement latency. A predictor of recurrence in depression. , 1987, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[25]  Angelo Gemignani,et al.  REM sleep dysregulation in depression: state of the art. , 2013, Sleep medicine reviews.

[26]  M. Farooq,et al.  Estimation and Decision Fusion: A Survey , 2006 .