Epigenetic mechanisms in human disease.

Departments of Medicine, Oncology, and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 [A. P. F.]; Department ofMolecular and Cellular Genetics, School of Life Sciences, Tottori University, Tottori 683, Japan [M. O.]; and Center for Cancer Research, National Cancer Institute, Bethesda,Maryland 20892 [J. C. B.]

[1]  A. Feinberg,et al.  Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. , 2002, Cancer research.

[2]  J. J. Breen,et al.  BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S. Pääbo,et al.  Intra- and Interspecific Variation in Primate Gene Expression Patterns , 2002, Science.

[4]  Andrew P Feinberg,et al.  A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. , 2002, Genome research.

[5]  Andrew P Feinberg,et al.  Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. , 2002, American journal of human genetics.

[6]  K. Muegge,et al.  Lsh, a member of the SNF2 family, is required for genome-wide methylation. , 2001, Genes & development.

[7]  R Ohlsson,et al.  CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. , 2001, Trends in genetics : TIG.

[8]  A. Feinberg,et al.  Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. , 2001, Cancer research.

[9]  F. Ding,et al.  Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene , 2001, Cell.

[10]  J. J. Robinson,et al.  Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture , 2001, Nature Genetics.

[11]  V. Corces,et al.  Chromatin insulators and boundaries: effects on transcription and nuclear organization. , 2001, Annual review of genetics.

[12]  M. Meguro,et al.  Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome. , 2000, Human molecular genetics.

[13]  D. Higgs,et al.  Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation , 2000, Nature Genetics.

[14]  M. Marra,et al.  Genetic definition and sequence analysis of Arabidopsis centromeres. , 1999, Science.

[15]  N. Tommerup,et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.

[16]  H. Zoghbi,et al.  Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 , 1999, Nature Genetics.

[17]  J W Gray,et al.  NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A. Feinberg,et al.  Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability , 1998, Nature Medicine.

[19]  M. Lalande,et al.  UBE3A/E6-AP mutations cause Angelman syndrome , 1996, Nature Genetics.

[20]  Bernhard Horsthemke,et al.  Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15 , 1995, Nature Genetics.

[21]  A. Feinberg,et al.  Relaxation of imprinted genes in human cancer , 1993, Nature.

[22]  A. Feinberg,et al.  Hypomethylation distinguishes genes of some human cancers from their normal counterparts , 1983, Nature.

[23]  R. Berezney,et al.  Nuclear protein matrix: association with newly synthesized DNA. , 1975, Science.