THE EFFECT OF THEELIN INJECTIONS ON THE CASTRATED WOMAN

The object of these experiments was to determine the effect of various dosages of theelin on human female castrates of different ages and varying length periods of castration. It was of particular interest to study the effect of this hormone on the subjective symptoms that accompany castration and on the involutionary changes that occur in the breasts and the genital tract following ovariectomy. Stockard and Papanicolaou1described an exact method for following the estrual changes in the living guinea-pig by the vaginal smear. This method has been applied to the correlation of the estrual phenomena in the genital organs of the rat2and the mouse.3Allen and Doisy,4employing ovarian follicle fluid from hogs, produced pubertas praecox in immature albino rats. The vagina of the immature rat is completely closed, its external third being a solid cord of cells. They found that the injection of the

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