Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB.

[1]  B. Hemmings,et al.  PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage , 2010, Oncogene.

[2]  Qing‐Yu He,et al.  Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways , 2010, Proteomics.

[3]  G. Jung,et al.  The hepatitis B viral X protein activates NF‐κB signaling pathway through the up‐regulation of TBK1 , 2010, FEBS letters.

[4]  D. Xie,et al.  Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF‐κB signaling pathway , 2010, Hepatology.

[5]  S. Kulp,et al.  Targeting of the Akt-Nuclear Factor-κB Signaling Network by [1-(4-Chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma , 2009, Molecular Pharmacology.

[6]  Y. Song,et al.  Genistein Inhibits Cell Growth by Modulating Various Mitogen‐Activated Protein Kinases and AKT in Cervical Cancer Cells , 2009, Annals of the New York Academy of Sciences.

[7]  Menggang Yu,et al.  NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy. , 2009, Cancer letters.

[8]  Shadan Ali,et al.  Retracted: Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines , 2009, Cancer.

[9]  Zhen Fan Yang,et al.  An Akt/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Mediates Hypoxia-Induced Chemoresistance in Liver Cancer Cells and Tumorigenic Hepatic Progenitor Cells , 2009, Clinical Cancer Research.

[10]  W. Lau,et al.  The Current Role of Radiofrequency Ablation in the Management of Hepatocellular Carcinoma: A Systematic Review , 2009, Annals of surgery.

[11]  C. Tepper,et al.  Genistein combined polysaccharide enhances activity of docetaxel, bicalutamide and Src kinase inhibition in androgen‐dependent and independent prostate cancer cell lines , 2008, BJU international.

[12]  Zhiwei Wang,et al.  Multi-targeted therapy of cancer by genistein. , 2008, Cancer letters.

[13]  G. Krissansen,et al.  Antisense hypoxia‐inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma , 2008, Cancer science.

[14]  Kuen-Feng Chen,et al.  Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. , 2008, Cancer research.

[15]  L. Roberts Sorafenib in liver cancer--just the beginning. , 2008, The New England journal of medicine.

[16]  J. Llovet,et al.  Molecular targeted therapies in hepatocellular carcinoma: from pre-clinical models to clinical trials. , 2008, Journal of hepatology.

[17]  H. El‐Serag,et al.  Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. , 2007, Gastroenterology.

[18]  G. Blackburn,et al.  Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. , 2007, Carcinogenesis.

[19]  Shadan Ali,et al.  Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. , 2006, Cancer research.

[20]  Chih-Hung Hsu,et al.  Arsenic trioxide in patients with hepatocellular carcinoma: a phase II trial , 2006, Investigational New Drugs.

[21]  G. Krissansen,et al.  Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice , 2006, Cancer science.

[22]  G. Krissansen,et al.  Arsenic trioxide synergizes with B7H3‐mediated immunotherapy to eradicate hepatocellular carcinomas , 2006, International journal of cancer.

[23]  Tak W. Mak,et al.  Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis , 2006, Nature Reviews Cancer.

[24]  Yan Gu,et al.  Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. , 2005, World journal of gastroenterology.

[25]  Shadan Ali,et al.  Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. , 2005, Cancer research.

[26]  S. Hirohashi,et al.  Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma , 2005, Cancer.

[27]  B. Aggarwal Nuclear factor-κB: The enemy within , 2004 .

[28]  Yuan-fang Liu,et al.  All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Y. Akao,et al.  Antitumor effect of arsenic trioxide in murine xenograft model , 2003, Cancer science.

[30]  E. Roth,et al.  Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. , 2003, Blood.

[31]  Y. Terada,et al.  The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. , 2003, Journal of the American Society of Nephrology : JASN.

[32]  M. Tai,et al.  Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma , 2003, Cancer.

[33]  T. Arima,et al.  Inhibition by arsenic trioxide of human hepatoma cell growth. , 2002, Cancer Letters.

[34]  S. Soignet Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia. , 2001, The oncologist.

[35]  M. Mayo,et al.  Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB , 2000, Molecular and Cellular Biology.

[36]  W. Liao,et al.  Phosphatidylinositol 3-Kinase as a Mediator of TNF-Induced NF-κB Activation1 , 2000, The Journal of Immunology.

[37]  G. Blackburn,et al.  Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. , 1998, Cancer research.

[38]  N. Andrews,et al.  A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. , 1991, Nucleic acids research.

[39]  S J Chen,et al.  Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. , 1999, Blood.