Intermolecular Communication on Lipid Bilayer Membrane. Tuning of Enzymatic Activity with Phase Transition of the Matrix Membranes

A molecular device, in which the catalytic activity of lactate dehydrogenase was controlled by a response of ditopic molecular recognition of a lipid signal, was constructed on lipid bilayer membranes. The enzymatic activity was tuned up sensitively through phase transition of the matrix membrane as a platform for the intermolecular communication.