Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway

[1]  Mark A Sussman,et al.  Myocardial AKT: the omnipresent nexus. , 2011, Physiological reviews.

[2]  L. Mandarino,et al.  The identification of raptor as a substrate for p44/42 MAPK. , 2011, Endocrinology.

[3]  E. Haura,et al.  JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling , 2011, Molecular Cancer Therapeutics.

[4]  D. Rubinsztein,et al.  Regulation of mammalian autophagy in physiology and pathophysiology. , 2010, Physiological reviews.

[5]  Hongyu Zhou,et al.  The complexes of mammalian target of rapamycin. , 2010, Current protein & peptide science.

[6]  G. Hortobagyi,et al.  Targeting p70S6K Prevented Lung Metastasis in a Breast Cancer Xenograft Model , 2010, Molecular Cancer Therapeutics.

[7]  G. Semenza,et al.  Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression , 2010, Proceedings of the National Academy of Sciences.

[8]  L. Tanoue.  Cancer Statistics, 2009 , 2010 .

[9]  J. Fridman,et al.  INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. , 2010, Neoplasia.

[10]  Wei Zhao,et al.  Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation , 2010, Journal of Cancer Research and Clinical Oncology.

[11]  S. Schreiber,et al.  Direct control of mitochondrial function by mTOR , 2009, Proceedings of the National Academy of Sciences.

[12]  R. Memmott,et al.  The Role of the Akt/mTOR Pathway in Tobacco Carcinogen–Induced Lung Tumorigenesis , 2009, Clinical Cancer Research.

[13]  A. Yoshizawa,et al.  Overexpression of Phospho-eIF4E Is Associated with Survival through AKT Pathway in Non–Small Cell Lung Cancer , 2009, Clinical Cancer Research.

[14]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[15]  S. H. Lee,et al.  Mutational analysis of JAK1 gene in human hepatocellular carcinoma. , 2009, Neoplasma.

[16]  A. Tackett,et al.  Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance* , 2008, Journal of Biological Chemistry.

[17]  A. Baldwin,et al.  Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer. , 2008, Cancer research.

[18]  Y. Chung,et al.  Somatic Mutations of JAK1 and JAK3 in Acute Leukemias and Solid Cancers , 2008, Clinical Cancer Research.

[19]  C. Doglioni,et al.  Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. , 2008, Blood.

[20]  R. Wilson,et al.  Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. , 2008, Blood.

[21]  Zhiwei Wang,et al.  Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. , 2008, Cancer research.

[22]  Ying-Xuan Chen,et al.  Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. , 2008, Neoplasia.

[23]  R. Wilson,et al.  Identification of somatic JAK 1 mutations in patients with acute myeloid leukemia , 2008 .

[24]  C. Roumestand,et al.  Proto‐oncogene TCL1: more than just a coactivator for Akt , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  A. Pandiella,et al.  Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin. , 2007, Cellular signalling.

[26]  Didier Merlin,et al.  Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. , 2007, Cancer research.

[27]  G. Booz,et al.  Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. , 2007, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[28]  M. Hou,et al.  Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma. , 2007, Oncology reports.

[29]  I. Shiojima,et al.  Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. , 2006, Genes & development.

[30]  Z. Estrov,et al.  The JAK-STAT pathway: a therapeutic target in hematological malignancies. , 2006, Current cancer drug targets.

[31]  A. Wong,et al.  Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. , 2006, Endocrinology.

[32]  R. Guo,et al.  Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. , 2006, Lung cancer.

[33]  Cheng-Hsien Chen,et al.  Simultaneous activation of JAK1 and JAK2 confers IL‐3 independent growth on Ba/F3 pro‐B cells , 2005, Journal of cellular biochemistry.

[34]  D. Zagzag,et al.  Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[35]  K. Hui,et al.  A microarray study to characterize the molecular mechanism of TIMP-3-mediated tumor rejection. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  E. Raymond,et al.  mTOR-targeted therapy of cancer with rapamycin derivatives. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[37]  L. Cousens,et al.  JAK-Mediated Signaling Inhibits Fas Ligand-Induced Apoptosis Independent of De Novo Protein Synthesis1 , 2005, The Journal of Immunology.

[38]  Terry L. Smith,et al.  Activation of the Akt/Mammalian Target of Rapamycin/4E-BP1 Pathway by ErbB2 Overexpression Predicts Tumor Progression in Breast Cancers , 2004, Clinical Cancer Research.

[39]  N. Sonenberg,et al.  Upstream and downstream of mTOR. , 2004, Genes & development.

[40]  Amie Y Lee,et al.  Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer. , 2004, Clinical lung cancer.

[41]  A. Verma,et al.  Jak family of kinases in cancer , 2003, Cancer and Metastasis Reviews.

[42]  T. Harris,et al.  TOR Signaling , 2003, Science's STKE.

[43]  I. Dixon,et al.  Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. , 2003, Cardiovascular research.

[44]  M. Kelley,et al.  Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[45]  C. Phiel,et al.  Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium , 2003, Journal of Biological Chemistry.

[46]  T. Hunter,et al.  The Protein Kinase Complement of the Human Genome , 2002, Science.

[47]  G. Rao,et al.  5(S)-Hydroxyeicosatetraenoic Acid Stimulates DNA Synthesis in Human Microvascular Endothelial Cells via Activation of Jak/STAT and Phosphatidylinositol 3-Kinase/Akt Signaling, Leading to Induction of Expression of Basic Fibroblast Growth Factor 2* , 2002, The Journal of Biological Chemistry.

[48]  C. Schindler,et al.  Series Introduction: JAK-STAT signaling in human disease , 2002 .

[49]  S. W. Halvorsen,et al.  Activation and inactivation of signal transducers and activators of transcription by ciliary neurotrophic factor in neuroblastoma cells. , 2002, Cellular signalling.

[50]  Massimo Gadina,et al.  Cytokine Signaling in 2002 New Surprises in the Jak/Stat Pathway , 2002, Cell.

[51]  A. Gamero,et al.  Vanadate Facilitates Interferon α-mediated Apoptosis That Is Dependent on the Jak/Stat Pathway* , 2001, The Journal of Biological Chemistry.

[52]  E. Rosen,et al.  Constitutive activation of JAK–STAT3 signaling by BRCA1 in human prostate cancer cells , 2001, FEBS letters.

[53]  A. Gamero,et al.  Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway. , 2001, The Journal of biological chemistry.

[54]  A. Balmain,et al.  TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest , 2000 .

[55]  S. Rane,et al.  Janus kinases: components of multiple signaling pathways , 2000, Oncogene.

[56]  A. Balmain,et al.  TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. , 2000, Genes & development.

[57]  M. Roussel,et al.  Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.

[58]  Y. Fujio,et al.  Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes* , 1998, The Journal of Biological Chemistry.

[59]  J. Ihle.  The Janus protein tyrosine kinase family and its role in cytokine signaling. , 1995, Advances in immunology.