Towards improved hepatocyte cultures: Progress and limitations.

[1]  Meritxell Huch,et al.  Liver organoids: from basic research to therapeutic applications , 2019, Gut.

[2]  S. Itzkovitz,et al.  Spatial heterogeneity in the mammalian liver , 2019, Nature Reviews Gastroenterology & Hepatology.

[3]  Jaehwan Ahn,et al.  Human three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity , 2019, Journal of Biological Engineering.

[4]  G. Damm,et al.  Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity , 2019, International journal of molecular sciences.

[5]  E. Palma,et al.  Precision-cut liver slices: a versatile tool to advance liver research , 2018, Hepatology International.

[6]  H. Ijima,et al.  Fabrication of liver-derived extracellular matrix nanofibers and functional evaluation in in vitro culture using primary hepatocytes , 2018, Materialia.

[7]  Wiebke Albrecht.  Highlight report: New applications of chimeric mice with humanized livers , 2018, Archives of Toxicology.

[8]  Junjie Zhu,et al.  Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture , 2018, Cell.

[9]  C. Rice,et al.  Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids , 2018, Cell.

[10]  Y. Toh,et al.  A liver-immune coculture array for predicting systemic drug-induced skin sensitization. , 2018, Lab on a chip.

[11]  F. Schügner,et al.  A Standardized Collagen-Based Scaffold Improves Human Hepatocyte Shipment and Allows Metabolic Studies over 10 Days , 2018, Bioengineering.

[12]  Sean X. Sun,et al.  Cell tension and mechanical regulation of cell volume , 2018, Molecular biology of the cell.

[13]  BueschStefanie,et al.  A Novel In Vitro Liver Cell Culture Flow System Allowing Long-Term Metabolism and Hepatotoxicity Studies , 2018 .

[14]  M. Ingelman-Sundberg,et al.  Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells. , 2018, Tissue engineering. Part C, Methods.

[15]  M. Bunger,et al.  A Novel In Vitro Liver Cell Culture Flow System Allowing Long-Term Metabolism and Hepatotoxicity Studies , 2018, Applied In Vitro Toxicology.

[16]  M. Vinken,et al.  Characterization of hepatocyte-based in vitro systems for reliable toxicity testing , 2018, Archives of Toxicology.

[17]  Max Jackson,et al.  Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. , 2018, Biomaterials.

[18]  Q. Lv,et al.  Three-dimensional coculture of primary hepatocytes and stellate cells in silk scaffold improves hepatic morphology and functionality in vitro. , 2018, Journal of biomedical materials research. Part A.

[19]  Xin Yi Chan,et al.  Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate , 2018, Proceedings of the National Academy of Sciences.

[20]  Lay Poh Tan,et al.  Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro. , 2018, Acta biomaterialia.

[21]  F. Delbos,et al.  Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system , 2018, Scientific Reports.

[22]  Aurelien Forget,et al.  Discovering Cell-Adhesion Peptides in Tissue Engineering: Beyond RGD. , 2018, Trends in biotechnology.

[23]  Helen Horton,et al.  Precision-cut human liver slice cultures as an immunological platform. , 2018, Journal of immunological methods.

[24]  Gordana Vunjak-Novakovic,et al.  Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. , 2018, Cell stem cell.

[25]  Seiichi Ishida,et al.  Organs-on-a-chip: Current applications and consideration points for in vitro ADME-Tox studies. , 2018, Drug metabolism and pharmacokinetics.

[26]  Doris A Taylor,et al.  Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology , 2018, PloS one.

[27]  Frank Jacobs,et al.  Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study , 2018, Toxicological sciences : an official journal of the Society of Toxicology.

[28]  S. Sarin,et al.  Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs. , 2018, ACS applied materials & interfaces.

[29]  Su A Park,et al.  Prolongation of liver-specific function for primary hepatocytes maintenance in 3D printed architectures , 2018, Organogenesis.

[30]  P. Lapierre,et al.  From in vivo to in vitro: Major metabolic alterations take place in hepatocytes during and following isolation , 2017, PloS one.

[31]  S. Kimber,et al.  Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis , 2017, Tissue engineering. Part A.

[32]  J. B. van der Valk,et al.  Fetal Bovine Serum (FBS) — A Pain in the Dish? , 2017, Alternatives to laboratory animals : ATLA.

[33]  S. Khetani,et al.  A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells , 2017, Cellular and molecular gastroenterology and hepatology.

[34]  Jian-jun Zhang,et al.  Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival , 2017, Experimental cell research.

[35]  Hanry Yu,et al.  A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing , 2017, Scientific Reports.

[36]  Xin Xie,et al.  Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture , 2017, Scientific Reports.

[37]  Pavel Sumazin,et al.  A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism , 2017, Nature Communications.

[38]  J. Spence.  Clocking the Pace of Organoid Research , 2017, Cellular and molecular gastroenterology and hepatology.

[39]  Ali-Reza Sadri,et al.  De-liver CLiPs and revitalize hepatocytes. , 2017, Stem cell investigation.

[40]  Ans Punt,et al.  Non-animal approaches for toxicokinetics in risk evaluations of food chemicals. , 2017, ALTEX.

[41]  D. Cho,et al.  Development of Liver Decellularized Extracellular Matrix Bioink for Three-Dimensional Cell Printing-Based Liver Tissue Engineering. , 2017, Biomacromolecules.

[42]  Salman R Khetani,et al.  Engineered Liver Platforms for Different Phases of Drug Development. , 2017, Trends in biotechnology.

[43]  Ashok Kumar,et al.  Development of polymer based cryogel matrix for transportation and storage of mammalian cells , 2017, Scientific Reports.

[44]  T. Kietzmann.  Metabolic zonation of the liver: The oxygen gradient revisited , 2017, Redox biology.

[45]  F. Camargo,et al.  Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity. , 2017, Cell stem cell.

[46]  Y. Koyama,et al.  Liver inflammation and fibrosis. , 2017, The Journal of clinical investigation.

[47]  Thierry Lavé,et al.  Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling , 2017, The AAPS Journal.

[48]  Sabine U. Vorrink,et al.  Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation , 2016, Hepatology.

[49]  Meng Li,et al.  Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins , 2016, PloS one.

[50]  S. Tasoglu,et al.  A Bioprinted Liver-on-a-Chip for Drug Screening Applications. , 2016, Trends in biotechnology.

[51]  Sharon Munn,et al.  Adverse outcome pathway development from protein alkylation to liver fibrosis , 2016, Archives of Toxicology.

[52]  G. Devi,et al.  Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. , 2016, Pharmacology & therapeutics.

[53]  V. Weaver,et al.  Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha , 2016, Hepatology.

[54]  M. Ingelman-Sundberg,et al.  A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity , 2016, Archives of Toxicology.

[55]  Nils Blüthgen,et al.  Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue , 2016, Archives of Toxicology.

[56]  Hans Clevers,et al.  Modeling Development and Disease with Organoids , 2016, Cell.

[57]  V. Jaks,et al.  The alterations in the extracellular matrix composition guide the repair of damaged liver tissue , 2016, Scientific Reports.

[58]  M. Ingelman-Sundberg,et al.  Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease , 2016, Scientific Reports.

[59]  S. Dooley,et al.  Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7 , 2016, Clinical Epigenetics.

[60]  Gail A. Van Norman,et al.  Drugs, Devices, and the FDA: Part 1 , 2016, JACC. Basic to translational science.

[61]  G. Damm,et al.  Protocol for Isolation of Primary Human Hepatocytes and Corresponding Major Populations of Non-parenchymal Liver Cells. , 2016, Journal of visualized experiments : JoVE.

[62]  D. Hay,et al.  Fluid shear stress modulation of hepatocyte-like cell function , 2016, Archives of Toxicology.

[63]  Melvin E Andersen,et al.  Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. , 2016, Journal of pharmaceutical sciences.

[64]  S. Sarin,et al.  Fabrication of macroporous cryogels as potential hepatocyte carriers for bioartificial liver support. , 2015, Colloids and surfaces. B, Biointerfaces.

[65]  Yaakov Nahmias,et al.  Long-term culture and expansion of primary human hepatocytes , 2015, Nature Biotechnology.

[66]  P. Gissen,et al.  Structural and functional hepatocyte polarity and liver disease , 2015, Journal of hepatology.

[67]  J. Gerlach,et al.  Serum‐free culture of primary human hepatocytes in a miniaturized hollow‐fibre membrane bioreactor for pharmacological in vitro studies , 2015, Journal of tissue engineering and regenerative medicine.

[68]  D. Dhar,et al.  Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation , 2015, Scientific Reports.

[69]  J. Wiśniewski,et al.  Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure. , 2015, Journal of proteome research.

[70]  J. Hengstler,et al.  Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells , 2015, Experimental biology and medicine.

[71]  L. DeLeve.  Liver sinusoidal endothelial cells in hepatic fibrosis , 2015, Hepatology.

[72]  Georges Noel,et al.  Three-Dimensional Cell Culture: A Breakthrough in Vivo , 2015, International journal of molecular sciences.

[73]  G. Damm,et al.  3D Cultivation Techniques for Primary Human Hepatocytes , 2015, Microarrays.

[74]  Hans Clevers,et al.  Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver , 2015, Cell.

[75]  Doo-Hoon Lee,et al.  Hepatocyte Isolation, Culture, and Its Clinical Applications , 2014 .

[76]  U. Mansmann,et al.  An Algorithm that Predicts the Viability and the Yield of Human Hepatocytes Isolated from Remnant Liver Pieces Obtained from Liver Resections , 2014, PloS one.

[77]  Juergen A. Knoblich,et al.  Organogenesis in a dish: Modeling development and disease using organoid technologies , 2014, Science.

[78]  M. Vinken.  The adverse outcome pathway concept: a pragmatic tool in toxicology. , 2013, Toxicology.

[79]  P. Hayes,et al.  Profiling the Impact of Medium Formulation on Morphology and Functionality of Primary Hepatocytes in vitro , 2013, Scientific Reports.

[80]  Adam S. Hayward,et al.  Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME , 2013, Archives of Toxicology.

[81]  Cheng-Hsien Liu,et al.  Liver-cell patterning lab chip: mimicking the morphology of liver lobule tissue. , 2013, Lab on a chip.

[82]  Jerry C. Hu,et al.  Self-organization and the self-assembling process in tissue engineering. , 2013, Annual review of biomedical engineering.

[83]  G. Damm,et al.  Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity , 2013, Archives of Toxicology.

[84]  C. V. van Blitterswijk,et al.  Spheroid culture as a tool for creating 3D complex tissues. , 2013, Trends in biotechnology.

[85]  H. Clevers,et al.  In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration , 2013, Nature.

[86]  Clare M Waterman,et al.  Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior , 2012, Nature Protocols.

[87]  U. Rauen,et al.  Cold Storage of Rat Hepatocyte Suspensions for One Week in a Customized Cold Storage Solution – Preservation of Cell Attachment and Metabolism , 2012, PloS one.

[88]  Andreas Luch,et al.  Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays? , 2012, Trends in pharmacological sciences.

[89]  T. Vanhaecke,et al.  Primary hepatocyte cultures as in vitro tools for toxicity testing: quo vadis? , 2012, Toxicology in vitro : an international journal published in association with BIBRA.

[90]  N. Cherrington,et al.  Drug metabolism alterations in nonalcoholic fatty liver disease , 2011, Drug metabolism reviews.

[91]  L. Sandrin,et al.  Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies , 2011, Hepatic medicine : evidence and research.

[92]  C. Kieda,et al.  Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia , 2011, Journal of cellular and molecular medicine.

[93]  R. Bhogal,et al.  Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience , 2011, PloS one.

[94]  F. O'Brien.  Biomaterials & scaffolds for tissue engineering , 2011 .

[95]  A. Ahluwalia,et al.  Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes , 2011, Biotechnology journal.

[96]  Paul A. Janmey,et al.  Mechanisms of mechanical signaling in development and disease , 2011, Journal of Cell Science.

[97]  P. Olinga,et al.  Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies , 2010, Nature Protocols.

[98]  D. Adams,et al.  Mechanisms of immune-mediated liver injury. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[99]  G. Lajoie,et al.  Matrigel: A complex protein mixture required for optimal growth of cell culture , 2010, Proteomics.

[100]  Xavier Stéphenne,et al.  Hepatocyte cryopreservation: is it time to change the strategy? , 2010, World journal of gastroenterology.

[101]  Thomas Hartung,et al.  Are in vitro tests suitable for regulatory use? , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[102]  Vera Rogiers,et al.  Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation. , 2009, Journal of hepatology.

[103]  ET Morgan,et al.  Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics , 2009, Clinical pharmacology and therapeutics.

[104]  S. Koenig,et al.  Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells , 2009, In Vitro Cellular & Developmental Biology - Animal.

[105]  R. Wells.  Cellular sources of extracellular matrix in hepatic fibrosis. , 2008, Clinics in liver disease.

[106]  Carl-Fredrik Mandenius,et al.  Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology , 2008, Cytotechnology.

[107]  Agustín Lahoz,et al.  Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation , 2008, Cell transplantation.

[108]  S. Todo,et al.  Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy , 2008, Cell transplantation.

[109]  B. Dontchos,et al.  Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storage , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[110]  R. Wells.  The role of matrix stiffness in regulating cell behavior , 2008, Hepatology.

[111]  F. Pampaloni,et al.  The third dimension bridges the gap between cell culture and live tissue , 2007, Nature Reviews Molecular Cell Biology.

[112]  W. Schmidt-Heck,et al.  Improvement of metabolic performance of primary hepatocytes in hyperoxic cultures by vitamin C in a novel small-scale bioreactor , 2007 .

[113]  Albert P. Li,et al.  Human hepatocytes: isolation, cryopreservation and applications in drug development. , 2007, Chemico-biological interactions.

[114]  T. Vanhaecke,et al.  Differential role of epigenetic modulators in malignant and normal stem cells: a novel tool in preclinical in vitro toxicology and clinical therapy , 2007, Archives of Toxicology.

[115]  Hanry Yu,et al.  Perfusion culture improves the maintenance of cultured liver tissue slices. , 2007, Tissue engineering.

[116]  C. Martinez-Jimenez,et al.  Transcriptional regulation and expression of CYP3A4 in hepatocytes. , 2007, Current drug metabolism.

[117]  R. de Kanter,et al.  Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction , 2006, Expert opinion on drug metabolism & toxicology.

[118]  Vera Rogiers,et al.  Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. , 2006, Current drug metabolism.

[119]  Luke O Dannenberg,et al.  Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation , 2006, BMC Genomics.

[120]  J. Waring,et al.  GENE EXPRESSION IN HUMAN HEPATOCYTES IN SUSPENSION AFTER ISOLATION IS SIMILAR TO THE LIVER OF ORIGIN, IS NOT AFFECTED BY HEPATOCYTE COLD STORAGE AND CRYOPRESERVATION, BUT IS STRONGLY CHANGED AFTER HEPATOCYTE PLATING , 2006, Drug Metabolism and Disposition.

[121]  P. Bernardi,et al.  High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening , 2006, Archives of Toxicology.

[122]  Ronald T Raines,et al.  Self-assembly of synthetic collagen triple helices. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[123]  Vera Rogiers,et al.  Involvement of Cell Junctions in Hepatocyte Culture Functionality , 2006, Critical reviews in toxicology.

[124]  S. Koenig,et al.  Functional Characterization of Serum-Free Cultured Rat Hepatocytes for Downstream Transplantation Applications , 2005, Cell transplantation.

[125]  K. Jungermann,et al.  Induction in primary culture of 'gluconeogenic' and 'glycolytic' hepatocytes resembling periportal and perivenous cells. , 2005, European journal of biochemistry.

[126]  Vera Rogiers,et al.  Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. , 2004, Current medicinal chemistry.

[127]  G. Superti-Furga,et al.  Rediscovering the sweet spot in drug discovery. , 2003, Drug discovery today.

[128]  T. Vanhaecke,et al.  Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. , 2003, Journal of hepatology.

[129]  Wolzt,et al.  World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. , 2003, The Journal of the American College of Dentists.

[130]  K. Sugimachi,et al.  Histone deacetylase inhibitor trichostatin a induces cell‐cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells , 2003, International journal of cancer.

[131]  K. Olthoff.  Can reperfusion injury of the liver be prevented? Trying to improve on a good thing , 2001, Pediatric transplantation.

[132]  Wolzt,et al.  World Medical Association Declaration of Helsinki , 2000, International Journal of Pharmaceutical Medicine.

[133]  H. Toutain,et al.  Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. , 2000, Toxicology.

[134]  P Smith,et al.  Concordance of the toxicity of pharmaceuticals in humans and in animals. , 2000, Regulatory toxicology and pharmacology : RTP.

[135]  P. Moghe,et al.  Control of hepatocyte function on collagen foams: sizing matrix pores toward selective induction of 2-D and 3-D cellular morphogenesis. , 2000, Biomaterials.

[136]  S. Bailey,et al.  Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers , 2000, Free radical research.

[137]  M L Yarmush,et al.  Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[138]  A. Li,et al.  Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. , 1999, Chemico-biological interactions.

[139]  I. Phillips,et al.  Cytochrome P450 Protocols , 1998, Methods in Molecular Biology.

[140]  P. Amenta,et al.  The hepatic extracellular matrix , 1993, Virchows Archiv A.

[141]  J. B. Stevens,et al.  The effect of oxygen tension on rat hepatocytes in short-term culture , 1987, In Vitro Cellular & Developmental Biology.

[142]  N. Marceau,et al.  Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities , 1985, The Journal of cell biology.

[143]  A. Guillouzo,et al.  Long‐Term Co‐Cultures of Adult Human Hepatocytes with Rat Liver Epithelial Cells: Modulation of Albumin Secretion and Accumulation of Extracellular Material , 1984, Hepatology.

[144]  L. Liotta,et al.  Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. , 1982, Biochemistry.

[145]  M. Rojkind,et al.  LONG‐TERM CULTURES OF NORMAL RAT HEPATOCYTES ON LIVER BIOMATRIX , 1980, Annals of the New York Academy of Sciences.

[146]  J. Fraczek,et al.  Epigenetic Modifications as Antidedifferentiation Strategy for Primary Hepatocytes in Culture. , 2015, Methods in molecular biology.

[147]  W. Haefeli,et al.  Association of liver stiffness with hepatic expression of pharmacokinetically important genes in alcoholic liver disease. , 2013, Alcoholism, clinical and experimental research.

[148]  Ivan Rusyn,et al.  In vitro models for liver toxicity testing. , 2013, Toxicology research.

[149]  A. Nüssler,et al.  Long-term culture of primary hepatocytes: new matrices and microfluidic devices , 2013, Hepatology International.

[150]  J. Hengstler,et al.  Human hepatocytes: isolation, culture, and quality procedures. , 2012, Methods in molecular biology.

[151]  S. Strom,et al.  Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. , 2010, Methods in molecular biology.

[152]  A. Capitano,et al.  Induction of Zone‐Like Liver Function Gradients in HepG2 Cells by Varying Culture Medium Height , 2007, Biotechnology progress.

[153]  Jean S. Campbell,et al.  The role of hepatocytes and oval cells in liver regeneration and repopulation , 2003, Mechanisms of Development.

[154]  Z. Kmieć.  Cooperation of Liver Cells in the Synthesis and Degradation of Eicosanoids , 2001 .