Microtubule dynamics regulated by stathmin

Microtubules perform a variety of functions which lead to the complex regulation of intracellular transport and cell division. However, the regulation of microtubule growth is not clearly known. Based on a recent experimental finding, we explore the possibility of spatial regulation of microtubule growth by stathmin-tubulin interaction gradients. Computer simulation of the model with stathmin-tubulin interaction gradients gave regulated growth as seen in experiments. In future, the stathmin-tubulin interaction gradients can be made dynamic and its impact on the microtubule growth can be explored.

[1]  E. Salmon,et al.  How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation. , 1993, Molecular biology of the cell.

[2]  R. Heald,et al.  Regulation of Op 18 during Spindle Assembly in Xenopus Egg Extracts , 2001 .

[3]  Eric Karsenti,et al.  Stathmin-Tubulin Interaction Gradients in Motile and Mitotic Cells , 2004, Science.

[4]  R. Heald,et al.  Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts , 2001, The Journal of cell biology.

[5]  D. Chowdhury,et al.  Dynamic instability of microtubules: effect of catastrophe-suppressing drugs. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[6]  M. Schilstra,et al.  A simple formulation of microtubule dynamics: quantitative implications of the dynamic instability of microtubule populations in vivo and in vitro. , 1989, Journal of cell science.

[7]  Leslie Wilson,et al.  Microtubule Polymerization Dynamics, Mitotic Block, and Cell Death by Paclitaxel at Low Concentrations , 1994 .

[8]  H. Buettner,et al.  Time series characterization of simulated microtubule dynamics in the nerve growth cone , 1995, Annals of Biomedical Engineering.

[9]  T. Mitchison,et al.  Catastrophic revelations about Op18/stathmin. , 1996, Trends in biochemical sciences.

[10]  M. Gullberg,et al.  Deciphering the cellular functions of the Op18/Stathmin family of microtubule-regulators by plasma membrane-targeted localization. , 2003, Molecular biology of the cell.

[11]  Eric Karsenti,et al.  Spatial Coordination of Spindle Assembly by Chromosome-Mediated Signaling Gradients , 2005, Science.

[12]  O. Gavet,et al.  The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. , 1998, Journal of cell science.

[13]  M J Schilstra,et al.  Dynamic instability of microtubules: Monte Carlo simulation and application to different types of microtubule lattice. , 1993, Biophysical journal.

[14]  E D Salmon,et al.  Real-time observations of microtubule dynamic instability in living cells , 1988, The Journal of cell biology.

[15]  G. Atweh,et al.  The role of stathmin in the regulation of the cell cycle , 2004, Journal of cellular biochemistry.

[16]  S. Leibler,et al.  Physical aspects of the growth and regulation of microtubule structures. , 1993, Physical review letters.