Antibacterial and Antioxidant Activities of Various Medicinal Plants Used in Oriental Medicine

The antibacterial activities of the ethanol extracts of 35 medicinal plants were screened against Escherichia coli, Bacillus cereus, and Staphylococcus aureus by following standard antimicrobial susceptibility testing procedures. The ethanol extracts of Coptis chinensis and Glycyrrhiza uralensis showed antibacterial activity against all three test bacterial species. The screened extracts were also tested for their antioxidant activities using the DPPH free radical scavenging activity assay, and for their cytotoxic and antioxidant activity in vitro using an assessment of cell viability on mouse embryonic fibroblast cells. The ethanol extracts of both C. chinensis and G. uralensis showed good radical scavenging antioxidant properties and attenuated the rate of cell death caused by oxidative damage. Our results showed that C. chinensis and G. uralensis are promising sources of natural products with good antibacterial and antioxidant activities.

[1]  S. Kang,et al.  Chemical composition, antibacterial and antioxidant activities of leaf essential oil and extracts of Metasequioa glyptostroboides Miki ex Hu. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[2]  C. Rossi,et al.  Antimicrobial activity against Helicobacter pylori strains and antioxidant properties of blackberry leaves (Rubus ulmifolius) and isolated compounds. , 2009, International journal of antimicrobial agents.

[3]  Kuo-Chen Chou,et al.  Drug candidates from traditional chinese medicines. , 2008, Current topics in medicinal chemistry.

[4]  A. Matkowski Plant in vitro culture for the production of antioxidants--a review. , 2008, Biotechnology advances.

[5]  T. Shibamoto,et al.  Antioxidant and anti-inflammatory activities of water distillate and its dichloromethane extract from licorice root (Glycyrrhiza uralensis) and chemical composition of dichloromethane extract , 2008 .

[6]  U. Lindequist,et al.  Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen. , 2007, Journal of ethnopharmacology.

[7]  A. Gurib-Fakim,et al.  Medicinal plants: traditions of yesterday and drugs of tomorrow. , 2006, Molecular aspects of medicine.

[8]  A. Norazah,et al.  In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. , 2005, Tropical biomedicine.

[9]  L. Bielory Complementary and alternative interventions in asthma, allergy, and immunology. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[10]  M. Karin,et al.  Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death , 2004, Molecular and Cellular Biology.

[11]  G. Catignani,et al.  Antioxidants and Prevention of Chronic Disease , 2004, Critical reviews in food science and nutrition.

[12]  M. Gershwin,et al.  Mushrooms, Tumors, and Immunity: An Update , 2004, Experimental biology and medicine.

[13]  K. Oh,et al.  Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Isoquinoline Alkaloids , 2004, Bioscience, biotechnology, and biochemistry.

[14]  L. Chiang,et al.  Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth , 2004, Clinical and experimental pharmacology & physiology.

[15]  Makio Kobayashi,et al.  Antibacterial Activity of Licochalcone A against Spore-Forming Bacteria , 2002, Antimicrobial Agents and Chemotherapy.

[16]  C. Giacomelli,et al.  Antioxidant capacity of phenolic and related compounds: correlation among electrochemical, visible spectroscopy methods and structure–antioxidant activity , 2001, Redox report : communications in free radical research.

[17]  M. M. Cowan Plant Products as Antimicrobial Agents , 1999, Clinical Microbiology Reviews.

[18]  T. Schöpke,et al.  Antimicrobial activity of some Nepalese medicinal plants. , 1999, Die Pharmazie.

[19]  R. Anderson,et al.  The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[20]  F. Mohammad,et al.  Screening of some Indian medicinal plants for their antimicrobial properties. , 1998, Journal of ethnopharmacology.

[21]  P. Taylor,et al.  Antimicrobial properties of green tea catechins. , 2005, Food science and technology bulletin.

[22]  R. Bukenya-Ziraba,et al.  Traditional herbal drugs of Southern Uganda, II: literature analysis and antimicrobial assays. , 2003, Journal of ethnopharmacology.