论文信息 - Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations

Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations

Article abstract A 19-month-old girl presented with severe neurologic symptoms associated with exanthem subitum. Human herpesvirus type 7 (HHV-7) DNA was detected in the CSF and serum, and supported by serologic studies. The patient was diagnosed with encephalopathy due to an acute HHV-7 infection. Neuron-specific enolase in the CSF was strongly elevated during the acute stage of infection, suggesting that the encephalopathy was due to viral invasion of the brain.

[1] J. Levy. Three new human herpesviruses (HHV6, 7, and 8) , 1997, The Lancet.

[2] T. Peto,et al. Diagnosis of viral infections of the central nervous system: clinical interpretation of PCR results , 1997, The Lancet.

[3] K. Yamanishi,et al. Human herpesvirus 7 infection associated with central nervous system manifestations. , 1996, The Journal of pediatrics.

[4] P. Griffiths,et al. Measurement of human herpesvirus 7 load in peripheral blood and saliva of healthy subjects by quantitative polymerase chain reaction. , 1996, The Journal of infectious diseases.

[5] G. Borm,et al. Cerebrospinal neuron‐specific enolase, S‐100 and myelin basic protein in neurological disorders , 1995, Acta neurologica Scandinavica.

[6] P. Secchiero,et al. Quantitative PCR for human herpesviruses 6 and 7 , 1995, Journal of clinical microbiology.

[7] J. Galama,et al. Active human herpesvirus 6 infection in an adolescent male. , 1995, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8] L. Epstein,et al. Neuroinvasion and persistence of human herpesvirus 6 in children. , 1994, The Journal of infectious diseases.

[9] H. Agut,et al. In vitro sensitivity of human herpesvirus-6 to antiviral drugs. , 1989, Research in virology.