Hype and hypernation : multiple hyphenation of column liquid chromatography and spectroscopy

[1]  A G Swanson,et al.  High-performance liquid chromatography/NMR spectrometry/mass spectrometry: further advances in hyphenated technology. , 1997, Journal of mass spectrometry : JMS.

[2]  R. Smith,et al.  Selective deuterium exchange during superheated heavy water chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry of sulfonamides. , 2000, Journal of chromatography. A.

[3]  I. Wilson,et al.  Reversed-phase high-performance liquid chromatography combined with on-line UV diode array, FT infrared, and 1H nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry: application to a mixture of nonsteroidal antiinflammatory drugs. , 2000, Analytical chemistry.

[4]  I. Wilson,et al.  High-Performance Liquid Chromatography On-Line Coupled to High-Field NMR and Mass Spectrometry for Structure Elucidation of Constituents of Hypericum perforatum L. , 1999 .

[5]  L. Angenot,et al.  LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. , 2004, Phytochemistry.

[6]  I. Wilson,et al.  Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS , 2000, Xenobiotica; the fate of foreign compounds in biological systems.

[7]  I. Wilson,et al.  Size-exclusion chromatography with on-line ultraviolet, proton nuclear magnetic resonance and mass spectrometric detection and on-line collection for off-line Fourier transform infrared spectroscopy. , 1999, Journal of Chromatography A.

[8]  I. Wilson,et al.  Application of inductively coupled plasma mass spectrometry and high-performance liquid chromatography--with parallel electrospray mass spectrometry to the investigation of the disposition and metabolic fate of 2-, 3- and 4-iodobenzoic acids in the rat. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[9]  I. Wilson,et al.  Hyphenation and hypernation the practice and prospects of multiple hyphenation. , 2003, Journal of chromatography. A.

[10]  I. Wilson,et al.  High temperature reversed-phase HPLC using deuterium oxide as a mobile phase for the separation of model pharmaceuticals with multiple on-line spectroscopic analysis (UV, IR, 1H-NMR and MS) , 2001 .

[11]  J. Fritsche,et al.  On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed. , 2002, Journal of chromatography. A.

[12]  I. Wilson,et al.  HPLC analysis of ecdysteroids in plant extracts using superheated deuterium oxide with multiple on-line spectroscopic analysis (UV, IR, 1H NMR, and MS). , 2002, Analytical chemistry.

[13]  E. Morgan,et al.  High performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy and mass spectrometry applied to plant products: Identification of ecdysteroids fromSilene otites , 1999 .

[14]  I. Wilson,et al.  Investigation of the metabolic fate of 2-, 3- and 4-bromobenzoic acids in bile-duct-cannulated rats by inductively coupled plasma mass spectrometry and high-performance liquid chromatography/inductively coupled plasma mass spectrometry/electrospray mass spectrometry. , 2005, Rapid communications in mass spectrometry : RCM.

[15]  I. Wilson,et al.  Application of directly coupled high-performance liquid chromatography-nuclear magnetic resonance-mass spectrometry to the detection and characterisation of the metabolites of 2-bromo-4-trifluoromethylaniline in rat urine , 1997 .

[16]  W. Lehmann,et al.  Element and molecular mass spectrometry—an emerging analytical dream team in the life sciences , 2004 .

[17]  R. Carle,et al.  Characterisation of betalain patterns of differently coloured inflorescences from Gomphrena globosa L. and Bougainvillea sp. by HPLC–DAD–ESI–MSn , 2007, Analytical and bioanalytical chemistry.

[18]  G. Balogh,et al.  The changing role of NMR spectroscopy in off-line impurity identification: A conceptual view , 2006 .

[19]  H. Stuppner,et al.  LC-DAD-MS/SPE-NMR hyphenation. A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens. , 2005, Analytical chemistry.

[20]  S. Laufer,et al.  In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS , 2007, Xenobiotica; the fate of foreign compounds in biological systems.

[21]  I. Wilson,et al.  Size exclusion chromatography with UV detection coupled to on-line 1H-NMR and on-line collection via a dedicated interface for subsequent off-line FT-IR , 1999 .

[22]  I. Wilson,et al.  Spectroscopic characterisation and identification of ecdysteroids using high-performance liquid chromatography combined with on-line UV--diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time of flight mass spectrometry. , 2001, Journal of chromatography. A.

[23]  K. Levsen,et al.  Combination of matrix solid-phase dispersion extraction and direct on-line liquid chromatography-nuclear magnetic resonance spectroscopy-tandem mass spectrometry as a new efficient approach for the rapid screening of natural products: application to the total asterosaponin fraction of the starfish A , 2001, Journal of chromatography. A.

[24]  I. Wilson,et al.  Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection. , 2000, Rapid communications in mass spectrometry : RCM.

[25]  Zhentian Lei,et al.  Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. , 2007, Phytochemistry.

[26]  I. Wilson,et al.  High-performance liquid chromatography-UV diode array, inductively coupled plasma mass spectrometry (ICMPS) and orthogonal acceleration time-of-flight mass spectrometry (oa-TOFMS) applied to the simultaneous detection and identification of metabolites of 4-bromoaniline in rat urine , 2002 .

[27]  J C Lindon,et al.  Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS. , 1999, Xenobiotica; the fate of foreign compounds in biological systems.

[28]  I. J. Fraser,et al.  A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry , 1998 .

[29]  Peter S Marshall,et al.  Study of bradykinin metabolism in human and rat plasma by liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry. , 2002, Rapid communications in mass spectrometry : RCM.

[30]  I. Wilson,et al.  Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants. , 2000, Journal of agricultural and food chemistry.

[31]  I. Wilson,et al.  Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: Measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS , 2006, Xenobiotica; the fate of foreign compounds in biological systems.

[32]  J. Balsevich,et al.  Analysis of bisdesmosidic saponins in Saponaria vaccaria L. by HPLC-PAD-MS: identification of new quillaic acid and gypsogenin 3-O-trisaccharides. , 2006, Phytochemical analysis : PCA.

[33]  A. M. Gil,et al.  Characterization of the aromatic composition of some liquid foods by nuclear magnetic resonance spectrometry and liquid chromatography with nuclear magnetic resonance and mass spectrometric detection , 2003 .

[34]  T. Hirschfeld,et al.  The hy-phen-ated methods , 1980 .

[35]  I. Wilson,et al.  Identification of the urinary metabolites of 4-bromoaniline and 4-bromo- [carbonyl - 13 C]-acetanilide in rat , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[36]  S. Menichetti,et al.  Hydrolyzable tannins with the hexahydroxydiphenoyl unit and the m-depsidic link: HPLC-DAD-MS identification and model synthesis. , 2007, Journal of agricultural and food chemistry.

[37]  I. Wilson,et al.  High-performance liquid chromatography linked to inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the simultaneous detection and identification of metabolites of 2-bromo-4-trifluoromethyl. , 2001, Analytical chemistry.

[38]  I. Wilson,et al.  Superheated Heavy Water as the Eluent for HPLC-NMR and HPLC-NMR-MS of Model Drugs , 1999 .

[39]  Weidong Zhang,et al.  Simultaneous analysis of alkaloids from Zanthoxylum nitidum by high performance liquid chromatography-diode array detector-electrospray tandem mass spectrometry. , 2006, Journal of pharmaceutical and biomedical analysis.

[40]  Frank S. Pullen,et al.  ‘On‐line’ liquid chromatography/nuclear magnetic resonance mass spectrometry—a powerful spectroscopic tool for the analysis of mixtures of pharmaceutical interest , 1995 .

[41]  G. Balogh,et al.  Estimation of impurity profiles of drugs and related materials: part 19: theme with variations. Identification of impurities in 3-oxosteroids. , 1998, Journal of pharmaceutical and biomedical analysis.

[42]  I. Wilson,et al.  Practical aspects of the use of high performance liquid chromatography combined with simultaneous nuclear magnetic resonance and mass spectrometry , 1998 .

[43]  I. Wilson,et al.  Reversed-phase HPLC of polymer additives with multiple on-line spectroscopic analysis (UV, IR, 1H NMR and MS) , 2002, Analytical and bioanalytical chemistry.

[44]  I. Wilson,et al.  High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds. , 2004, Rapid communications in mass spectrometry : RCM.

[45]  W. Pool,et al.  Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system. , 2002, Journal of pharmaceutical and biomedical analysis.

[46]  Yiyu Cheng,et al.  Quality evaluation of cortex moutan by high performance liquid chromatography coupled with diode array detector and electrospary ionization tandem mass spectrometry. , 2006, Chemical & pharmaceutical bulletin.

[47]  R. Withers,et al.  Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe: application to the analysis of acetaminophen metabolites in urine. , 2003, Analytical chemistry.

[48]  I. Wilson,et al.  A comparison of the quantitative methods for the analysis of the platinum-containing anticancer drug [cis-[amminedichloro(2-methylpyridine)]platinum(II)] (ZD0473) by HPLC coupled to either a triple quadrupole mass spectrometer or an inductively coupled plasma mass spectrometer. , 2003, Analytical chemistry.

[49]  I. Wilson,et al.  Superheated water chromatography-nuclear magnetic resonance spectroscopy and mass spectrometry of vitamins. , 2004, Journal of Pharmaceutical and Biomedical Analysis.

[50]  J P Shockcor,et al.  Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine. , 1996, Analytical chemistry.

[51]  I. Wilson,et al.  The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine , 1998 .

[52]  I. Wilson,et al.  19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling. , 1998, Xenobiotica; the fate of foreign compounds in biological systems.