Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions

[1]  H. Hilbi,et al.  Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors , 2015, Front. Immunol..

[2]  Kelly J Pittman,et al.  Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections , 2015, Microbiology and Molecular Reviews.

[3]  Laura A. L. Dillon,et al.  The generation of macrophages with anti‐inflammatory activity in the absence of STAT6 signaling , 2015, Journal of leukocyte biology.

[4]  A. Descoteaux,et al.  Leishmania survival in the macrophage: where the ends justify the means. , 2015, Current opinion in microbiology.

[5]  J. Rengarajan,et al.  Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells , 2015, Journal of immunology research.

[6]  C. Freire-de-Lima,et al.  Immune Evasion Strategies of Trypanosoma cruzi , 2015, Journal of immunology research.

[7]  Laura A. L. Dillon,et al.  Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation , 2015, Nucleic acids research.

[8]  J. M. Requena,et al.  Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes , 2015, BioMed research international.

[9]  J. Vicente,et al.  Mitosis, microtubule dynamics and the evolution of kinesins. , 2015, Experimental cell research.

[10]  E. Gosselin,et al.  Targeting of a Fixed Bacterial Immunogen to Fc Receptors Reverses the Anti-Inflammatory Properties of the Gram-Negative Bacterium, Francisella tularensis, during the Early Stages of Infection , 2015, PloS one.

[11]  Paul Theodor Pyl,et al.  HTSeq – A Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[12]  D. Roos,et al.  Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology , 2014, The Journal of investigative dermatology.

[13]  J. Clos,et al.  No stress – Hsp90 and signal transduction in Leishmania , 2014, Parasitology.

[14]  Björn Usadel,et al.  Trimmomatic: a flexible trimmer for Illumina sequence data , 2014, Bioinform..

[15]  M. Faron,et al.  Uncovering the components of the Francisella tularensis virulence stealth strategy , 2014, Front. Cell. Infect. Microbiol..

[16]  Charity W. Law,et al.  voom: precision weights unlock linear model analysis tools for RNA-seq read counts , 2014, Genome Biology.

[17]  C. Jaffe,et al.  Identification of a Secreted Casein Kinase 1 in Leishmania donovani: Effect of Protein over Expression on Parasite Growth and Virulence , 2013, PloS one.

[18]  B. Striepen,et al.  Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. , 2013, Progress in lipid research.

[19]  Peter W. Collingridge,et al.  Calmodulin is required for paraflagellar rod assembly and flagellum-cell body attachment in trypanosomes. , 2013, Protist.

[20]  Liang Zheng,et al.  Succinate is an inflammatory signal that induces IL-1β through HIF-1α , 2013, Nature.

[21]  Davis J. McCarthy,et al.  Count-based differential expression analysis of RNA sequencing data using R and Bioconductor , 2013, Nature Protocols.

[22]  J. Coppee,et al.  Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes , 2012, PLoS neglected tropical diseases.

[23]  M. Olivier,et al.  Leishmania virulence factors: focus on the metalloprotease GP63. , 2012, Microbes and infection.

[24]  Hongyu Zhao,et al.  Human Macrophage Response to L. (Viannia) panamensis: Microarray Evidence for an Early Inflammatory Response , 2012, PLoS neglected tropical diseases.

[25]  C. Pirmez,et al.  Transcriptome Patterns from Primary Cutaneous Leishmania braziliensis Infections Associate with Eventual Development of Mucosal Disease in Humans , 2012, PLoS neglected tropical diseases.

[26]  A. Rasche,et al.  Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View , 2012, PLoS neglected tropical diseases.

[27]  Arup Sarkar,et al.  Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis , 2012, Medical Microbiology and Immunology.

[28]  J. Cano,et al.  Leishmaniasis Worldwide and Global Estimates of Its Incidence , 2012, PloS one.

[29]  G. Buck,et al.  A comparison of two distinct murine macrophage gene expression profiles in response to Leishmania amazonensis infection , 2012, BMC Microbiology.

[30]  Anton J. Enright,et al.  Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion , 2011, BMC Evolutionary Biology.

[31]  G. H. Coombs,et al.  Morphological Events during the Cell Cycle of Leishmania major , 2011, Eukaryotic Cell.

[32]  P. Kaye,et al.  Leishmaniasis: complexity at the host–pathogen interface , 2011, Nature Reviews Microbiology.

[33]  P. Das,et al.  Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani , 2011, Molecular biology international.

[34]  W. Xu,et al.  Sphingolipid Degradation by Leishmania major Is Required for Its Resistance to Acidic pH in the Mammalian Host , 2011, Infection and Immunity.

[35]  M. Ronen,et al.  Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  K. Gull,et al.  The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology , 2010, Molecular microbiology.

[37]  Ralf Herwig,et al.  ConsensusPathDB: toward a more complete picture of cell biology , 2010, Nucleic Acids Res..

[38]  David M. Simcha,et al.  Tackling the widespread and critical impact of batch effects in high-throughput data , 2010, Nature Reviews Genetics.

[39]  Charles C. Kim,et al.  Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines , 2010, PLoS neglected tropical diseases.

[40]  Matthew D. Young,et al.  Gene ontology analysis for RNA-seq: accounting for selection bias , 2010, Genome Biology.

[41]  A. Ivens,et al.  Comparative Expression Profiling of Leishmania: Modulation in Gene Expression between Species and in Different Host Genetic Backgrounds , 2009, PLoS neglected tropical diseases.

[42]  F. Raymond,et al.  Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum. , 2009, Molecular and biochemical parasitology.

[43]  Lior Pachter,et al.  Sequence Analysis , 2020, Definitions.

[44]  José Osorio y Fortéa,et al.  Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes , 2009, BMC Genomics.

[45]  M. Fay,et al.  In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies , 2008, Science.

[46]  N. Ettinger,et al.  Macrophage and T-Cell Gene Expression in a Model of Early Infection with the Protozoan Leishmania chagasi , 2008, PLoS neglected tropical diseases.

[47]  Jacques Corbeil,et al.  Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species , 2008, BMC Genomics.

[48]  C. Shaha,et al.  Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence , 2008, Molecular microbiology.

[49]  R. Sladek,et al.  Comparison of the Effects of Leishmania major or Leishmania donovani Infection on Macrophage Gene Expression , 2007, Infection and Immunity.

[50]  C. Clayton,et al.  Post-transcriptional regulation of gene expression in trypanosomes and leishmanias. , 2007, Molecular and biochemical parasitology.

[51]  P. Bastien,et al.  A Novel Microtubule-Depolymerizing Kinesin Involved in Length Control of a Eukaryotic Flagellum , 2007, Current Biology.

[52]  K. Leifso,et al.  Genomic and proteomic expression analysis of Leishmania promastigote and amastigote life stages: the Leishmania genome is constitutively expressed. , 2007, Molecular and biochemical parasitology.

[53]  P. Myler,et al.  Analysis of the Leishmania donovani transcriptome reveals an ordered progression of transient and permanent changes in gene expression during differentiation. , 2007, Molecular and biochemical parasitology.

[54]  B. Nare,et al.  Inhibitors of casein kinase 1 block the growth of Leishmania major promastigotes in vitro. , 2006, International journal for parasitology.

[55]  M. Ouellette,et al.  A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum , 2006, Proteomics.

[56]  M. Ouellette,et al.  Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes. , 2006, Molecular and biochemical parasitology.

[57]  Timothy R Holzer,et al.  Expression profiling by whole-genome interspecies microarray hybridization reveals differential gene expression in procyclic promastigotes, lesion-derived amastigotes, and axenic amastigotes in Leishmania mexicana. , 2006, Molecular and biochemical parasitology.

[58]  M. Wiese,et al.  Interacting protein kinases involved in the regulation of flagellar length. , 2006, Molecular biology of the cell.

[59]  Y. Rikihisa.  Ehrlichia subversion of host innate responses. , 2006, Current opinion in microbiology.

[60]  Y. Belkaid,et al.  Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity , 2006, The Journal of experimental medicine.

[61]  J. M. Requena,et al.  Genomic DNA macroarrays as a tool for analysis of gene expression in Leishmania. , 2005, Experimental parasitology.

[62]  Heather J Munden,et al.  The Genome of the Kinetoplastid Parasite, Leishmania major , 2005, Science.

[63]  M. Olivier,et al.  Subversion Mechanisms by Which Leishmania Parasites Can Escape the Host Immune Response: a Signaling Point of View , 2005, Clinical Microbiology Reviews.

[64]  Daniel Kuhn,et al.  LmxMPK9, a mitogen‐activated protein kinase homologue affects flagellar length in Leishmania mexicana , 2005, Molecular microbiology.

[65]  G. Stormo,et al.  Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major. , 2004, Molecular and biochemical parasitology.

[66]  D. Vetrie,et al.  Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. , 2004, Molecular and biochemical parasitology.

[67]  M. Wilson,et al.  Novel Program of Macrophage Gene Expression Induced by Phagocytosis of Leishmania chagasi , 2004, Infection and Immunity.

[68]  Gordon K Smyth,et al.  Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .

[69]  Daniel Kuhn,et al.  Protein Kinase Involved in Flagellar-Length Control , 2003, Eukaryotic Cell.

[70]  Damien Chaussabel,et al.  Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. , 2003, Blood.

[71]  L. Scholtes,et al.  Functional Identification of Galactosyltransferases (SCGs) Required for Species-specific Modifications of the Lipophosphoglycan Adhesin Controlling Leishmania major-Sand Fly Interactions* , 2003, The Journal of Biological Chemistry.

[72]  W. Solbach,et al.  Neutrophil granulocytes--Trojan horses for Leishmania major and other intracellular microbes? , 2003, Trends in microbiology.

[73]  Kenneth Stuart,et al.  Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. , 2003, Molecular cell.

[74]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[75]  A. Chakraborty,et al.  A Single-domain Cyclophilin from Leishmania donovaniReactivates Soluble Aggregates of Adenosine Kinase by Isomerase-independent Chaperone Function* , 2002, The Journal of Biological Chemistry.

[76]  A. Sher,et al.  Evasion of innate immunity by parasitic protozoa , 2002, Nature Immunology.

[77]  T. Ilg.  Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene. , 2002, Molecular and biochemical parasitology.

[78]  H. Laufs,et al.  Intracellular Survival of Leishmania major in Neutrophil Granulocytes after Uptake in the Absence of Heat-Labile Serum Factors , 2002, Infection and Immunity.

[79]  S. Beverley,et al.  A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation. , 2001, Experimental parasitology.

[80]  Clare L. Bennett,et al.  Silent infection of bone marrow‐derived dendritic cells by Leishmania mexicana amastigotes , 2001, European journal of immunology.

[81]  G. Matlashewski,et al.  General Suppression of Macrophage Gene Expression During Leishmania donovani Infection1 , 2001, The Journal of Immunology.

[82]  D Sereno,et al.  A new developmentally regulated gene family in Leishmania amastigotes encoding a homolog of amastin surface proteins. , 2000, Molecular and biochemical parasitology.

[83]  C. Bogdan,et al.  Fibroblasts as Host Cells in Latent Leishmaniosis , 2000, The Journal of experimental medicine.

[84]  I. Müller,et al.  Progressive disease or protective immunity to Leishmania major infection: the result of a network of stimulatory and inhibitory interactions , 1998, Journal of Molecular Medicine.

[85]  V. Connor,et al.  Differential expression of Leishmania major beta-tubulin genes during the acquisition of promastigote infectivity. , 1996, Molecular and biochemical parasitology.

[86]  S. R. Uliana,et al.  Characterisation and expression of a stage-regulated gene of Leishmania major. , 1996, Molecular and biochemical parasitology.

[87]  C. Fadul,et al.  Survival of immunoglobulin G-opsonized Toxoplasma gondii in nonadherent human monocytes , 1995, Infection and immunity.

[88]  M. Kavanaugh,et al.  Functional expression of a myo-inositol/H+ symporter from Leishmania donovani , 1995, Molecular and cellular biology.

[89]  M. Kavanaugh,et al.  A Family of Putative Receptor-Adenylate Cyclases from Leishmania donovani(*) , 1995, The Journal of Biological Chemistry.

[90]  P. Scott,et al.  The role of the innate immune response in Th1 cell development following Leishmania major infection , 1995, Journal of leukocyte biology.

[91]  M. Röllinghoff,et al.  Dendritic cells in Leishmania major‐immune mice harbor persistent parasites and mediate an antigen‐specific T cell immune response , 1995, European journal of immunology.

[92]  E. Ullu,et al.  A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. , 1994, Genes & development.

[93]  S. Beverley,et al.  Coupling of poly(A) site selection and trans-splicing in Leishmania. , 1993, Genes & development.

[94]  E. Ullu,et al.  Temporal order of RNA-processing reactions in trypanosomes , 1993 .

[95]  B. F. Hall,et al.  CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. , 1989, Journal of immunology.

[96]  R. Locksley,et al.  Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote , 1988, Infection and immunity.

[97]  N. Saravia,et al.  Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival. , 2014, The Journal of antimicrobial chemotherapy.

[98]  D. Chaussabel,et al.  cells to phylogenetically distinct parasites Unique gene expression profiles of human macrophages and dendritic , 2013 .

[99]  Junmin Pan,et al.  Regulation of cilia assembly, disassembly, and length by protein phosphorylation. , 2009, Methods in cell biology.

[100]  S. Beverley,et al.  Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania. , 1998, Trends in microbiology.

[101]  R. Locksley,et al.  The regulation of immunity to Leishmania major. , 1995, Annual review of immunology.

[102]  D. Mosser,et al.  The third component of complement (C3) is responsible for the intracellular survival of Leishmania major , 1987, Nature.