While research has investigated the application of computational methodologies in undergraduate biology education, those approaches require students certain backgrounds from multiple disciplines. Recently, game design and development for education has moved into different fields of science, including biology. Several multi-media interactive products have been developed to simulate biological mechanisms and can be used by undergraduate students. However these approaches focus on students as game users and, not as game developers. Here, we propose an innovative approach to involve game design and development into undergraduate biology classroom. The approach assumes no additional background, and aims to increase engagement in the complexities of the course material through the process of game design and development. We initialized a case study that systematically combines a game application-driven project into genetics teaching. In the pedagogical experiment, undergraduate biology and computer science students designed educational games to enhance the speed and depth of comprehension of both biological and software engineering concepts. The result of this study shows that the reinforcement effects of biological education games apply differently on students with or without biology backgrounds.
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