Regulation of signal transduction by endocytosis.

Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the co-localization of activated receptors with downstream signaling molecules.

[1]  L. Bohn,et al.  Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence , 1999, The Journal of Neuroscience.

[2]  T. K. Yeung,et al.  Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulation. , 1999, Molecular biology of the cell.

[3]  R. G. Anderson.  The caveolae membrane system. , 1998, Annual review of biochemistry.

[4]  M. von Zastrow,et al.  Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction* , 1999, The Journal of Biological Chemistry.

[5]  R. Lefkowitz,et al.  Serotonin 5-HT1A Receptor-mediated Erk Activation Requires Calcium/Calmodulin-dependent Receptor Endocytosis* , 1999, The Journal of Biological Chemistry.

[6]  G. Carpenter,et al.  Interaction of Signaling and Trafficking Proteins with the Carboxyterminus of the Epidermal Growth Factor Receptor a , 1995, Annals of the New York Academy of Sciences.

[7]  J. Hancock,et al.  Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains , 1999, Nature Cell Biology.

[8]  R. Lefkowitz,et al.  Feedback Regulation of β-Arrestin1 Function by Extracellular Signal-regulated Kinases* , 1999, The Journal of Biological Chemistry.

[9]  E. Ikonen,et al.  Caveolins and Cellular Cholesterol Balance , 2000, Traffic.

[10]  M. Caron,et al.  Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.

[11]  R. Govers,et al.  The ubiquitin-proteasome system and endocytosis. , 1999, Journal of cell science.

[12]  P. Drake,et al.  Insulin receptor internalization and signalling , 1998 .

[13]  B. Geiger,et al.  Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency* , 1998, The Journal of Biological Chemistry.

[14]  F. Brodsky,et al.  EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake , 1999, Cell.

[15]  M. Caron,et al.  Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.

[16]  K. Jakobs,et al.  Regulation of Muscarinic Acetylcholine Receptor Sequestration and Function by β-Arrestin* , 1999, The Journal of Biological Chemistry.

[17]  T. Hunter,et al.  The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. , 1999, Science.

[18]  J. Srinivasan,et al.  Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans , 1999, Nature Cell Biology.

[19]  G. Carpenter,et al.  All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired (*) , 1996, The Journal of Biological Chemistry.

[20]  R. Lefkowitz,et al.  Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling* , 1999, The Journal of Biological Chemistry.

[21]  Y. Yarden,et al.  Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. , 1996, Oncogene.

[22]  G. Fiucci,et al.  Localization of Phospholipase D in Detergent-insoluble, Caveolin-rich Membrane Domains , 1999, The Journal of Biological Chemistry.

[23]  H. Wiley,et al.  The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling* , 1997, The Journal of Biological Chemistry.

[24]  N. Ling,et al.  Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase. , 1992, The Journal of biological chemistry.

[25]  B. Posner,et al.  Internalization and activation of the rat liver insulin receptor kinase in vivo. , 1989, The Journal of biological chemistry.

[26]  J. Pessin,et al.  Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways , 1998, Molecular and Cellular Biology.

[27]  Wei Yang,et al.  Role of Clathrin-mediated Endocytosis in CXCR2 Sequestration, Resensitization, and Signal Transduction* , 1999, The Journal of Biological Chemistry.

[28]  A. Lenferink,et al.  Differential endocytic routing of homo‐ and hetero‐dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers , 1998, The EMBO journal.

[29]  J. Engelman,et al.  Targeted downregulation of caveolin‐1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade , 1998, The EMBO journal.

[30]  J. Benovic,et al.  β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor , 1996, Nature.

[31]  S. Schmid,et al.  Induction of mutant dynamin specifically blocks endocytic coated vesicle formation , 1994, The Journal of cell biology.

[32]  B. Ljung,et al.  The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast. , 1992, Oncogene.

[33]  Z. Kam,et al.  c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. , 1998, Genes & development.

[34]  P. Sternberg,et al.  Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl , 1995, Science.

[35]  L. Limbird,et al.  Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis* , 1999, The Journal of Biological Chemistry.

[36]  M. Caron,et al.  Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.

[37]  A. Bretscher,et al.  A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor , 1999, Nature.

[38]  Y. Yarden,et al.  The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[39]  J. Benovic,et al.  Characterization of Dominant Negative Arrestins That Inhibit β2-Adrenergic Receptor Internalization by Distinct Mechanisms* , 1998, The Journal of Biological Chemistry.

[40]  Richard J. Lee,et al.  Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo , 1998, The Journal of Biological Chemistry.

[41]  I. Verlaan,et al.  Gi-mediated tyrosine phosphorylation of Grb2 (growth-factor-receptor-bound protein 2)-bound dynamin-II by lysophosphatidic acid. , 1999, The Biochemical journal.

[42]  S. Schmid,et al.  Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis , 1996, Science.

[43]  J. Benovic,et al.  Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. , 1996, Nature.

[44]  J. Engelman,et al.  Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo , 1998, FEBS letters.

[45]  Y. Yarden,et al.  The C‐terminus of the kinase‐defective neuregulin receptor ErbB‐3 confers mitogenic superiority and dictates endocytic routing , 1999, The EMBO journal.

[46]  J. Benovic,et al.  U50,488H-induced Internalization of the Human κ Opioid Receptor Involves a β-Arrestin- and Dynamin-dependent Mechanism , 1999, The Journal of Biological Chemistry.

[47]  J. Benovic,et al.  Role of Arrestins in Endocytosis and Signaling of α2-Adrenergic Receptor Subtypes* , 1999, The Journal of Biological Chemistry.

[48]  G. Carpenter,et al.  The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired. , 1993, Oncogene.