Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina

In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina and tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high–dorsal low gradient but also with a nasal high–temporal low gradient at later stages. Misexpression of Ventroptinaltered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes.

[1]  C. Cepko,et al.  Two homeobox genes define the domain of EphA3 expression in the developing chick retina. , 2000, Development.

[2]  Akira Kato,et al.  Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina , 2000, Mechanisms of Development.

[3]  O. Shimmi,et al.  Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation. , 2000, Developmental biology.

[4]  H. Nakamura,et al.  Tbx5 and the retinotectum projection. , 2000, Science.

[5]  U. Drescher,et al.  Topographic targeting and pathfinding errors of retinal axons following overexpression of ephrinA ligands on retinal ganglion cell axons. , 1999, Developmental biology.

[6]  C. Cepko,et al.  Misexpression of the Emx-Related Homeobox Genes cVax and mVax2 Ventralizes the Retina and Perturbs the Retinotectal Map , 1999, Neuron.

[7]  Franco Weth,et al.  Modulation of EphA Receptor Function by Coexpressed EphrinA Ligands on Retinal Ganglion Cell Axons , 1999, Neuron.

[8]  A. Fainsod,et al.  The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4 , 1997, Mechanisms of Development.

[9]  Jürgen Löschinger,et al.  Shared and distinct functions of RAGS and ELF‐1 in guiding retinal axons , 1997, The EMBO journal.

[10]  E. Robertson,et al.  Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos , 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

[11]  M. Yamagata,et al.  Visual projection map specified by topographic expression of transcription factors in the retina , 1996, Nature.

[12]  John G Flanagan,et al.  Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map , 1995, Cell.

[13]  H. Ichijo,et al.  Retinotectal projection after partial ablation of chick optic vesicles , 1992, Neuroscience Research.

[14]  W. Cowan,et al.  Studies on the development of the chick optic tectum. IV. An autoradiographic study of the development of retino-tectal connections , 1975, Brain Research.

[15]  W. Cowan,et al.  The specification of the retino‐tectal projection in the chick , 1974, The Journal of comparative neurology.

[16]  A. Kahn.  An autoradiographic analysis of the time of appearance of neurons in the developing chick neural retina. , 1974, Developmental biology.

[17]  R. Sperry.  CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[18]  William C. Smith.  TGFβ inhibitors: new and unexpected requirements in vertebrate development , 1999 .

[19]  J. Dowling,et al.  Retinoic acid establishes ventral retinal characteristics. , 1996, Development.

[20]  G. Kuwajima,et al.  Restriction landmark cDNA scanning (RLCS): a novel cDNA display system using two-dimensional gel electrophoresis. , 1996, Nucleic acids research.