Genomic overview of protein kinases.

Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. Bioinformatics and comparative genomics were used to determine the C. elegans kinome and put it in evolutionary and functional context. Kinases are deeply conserved in evolution, and the worm has family homologs for over 80% of the human kinome. Almost half of the 438 worm kinases are members of worm-specific or worm-expanded families. Such radiations include genes involved in spermatogenesis, chemosensation, Wnt signaling and FGF receptor-like kinases. The C. briggsae kinome is largely similar apart from the expanded classes, showing that such expansions are evolutionarily recent.

[1]  1David B. Morton.  Invertebrates yield a plethora of atypical guanylyl cyclases , 2004, Molecular Neurobiology.

[2]  R. Durbin,et al.  The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics , 2003, PLoS biology.

[3]  T. Hunter,et al.  The Protein Kinase Complement of the Human Genome , 2002, Science.

[4]  T. Hunter,et al.  Evolution of protein kinase signaling from yeast to man. , 2002, Trends in biochemical sciences.

[5]  S. Ward,et al.  Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene. , 2002, Genetics.

[6]  V. Reinke,et al.  A global profile of germline gene expression in C. elegans. , 2000, Molecular cell.

[7]  T. Johnson,et al.  Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans. , 2000, Molecular biology and evolution.

[8]  T. Hunter,et al.  The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D. Birnbaum,et al.  The family of Caenorhabditis elegans tyrosine kinase receptors: similarities and differences with mammalian receptors. , 1999, Genome research.

[10]  M. Meneghini,et al.  Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. , 1999, Genes & development.

[11]  J. Thomas,et al.  Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. , 1992, Genetics.