Hepatitis B vaccination in HIV-infected adults: current evidence, recommendations and practical considerations

Immunization with hepatitis B (HBV) vaccine is recommended for all HIV-infected individuals without immunity to HBV. This patient population, however, has relatively poor HBV vaccine responses. Factors associated with this impaired HBV vaccine response in HIV-infected individuals may include older age, uncontrolled HIV replication, and low nadir CD4 cell count. Postvaccination testing for HBV surface antibody is recommended and vaccine non-responders should undergo repeat immunization with a full series. The benefit of double dosage, the appropriate strategy for HIV-infected patients with isolated HBV core antibody and the timing and number of vaccinations in persons with advanced immunosuppression on highly active antiretroviral therapy remain controversial areas.

[1]  Helen M. Chun,et al.  Hepatitis B vaccination and risk of hepatitis B infection in HIV-infected individuals , 2010, AIDS.

[2]  C. Mengoli,et al.  Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients. , 2009, Vaccine.

[3]  P. Sax,et al.  Repeat hepatitis B vaccination may lead to seroprotection in HIV-infected patients who do not respond to an initial series. , 2009, Journal of acquired immune deficiency syndromes.

[4]  C. Bailey,et al.  Hepatitis B vaccine: a seven-year study of adherence to the immunization guidelines and efficacy in HIV-1-positive adults. , 2008, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[5]  E. Overton.  ACTG 5220: Hepatitis B Vaccine Responses in HIV-Infected Persons Using Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) , 2008 .

[6]  R. Harrington,et al.  Independent clinical predictors of impaired response to hepatitis B vaccination in HIV-infected persons , 2008, International journal of STD & AIDS.

[7]  J. Angel,et al.  CPG 7909 adjuvant plus hepatitis B virus vaccination in HIV-infected adults achieves long-term seroprotection for up to 5 years. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  R. D. de Man,et al.  A prospective open study of the efficacy of high-dose recombinant hepatitis B rechallenge vaccination in HIV-infected patients. , 2008, The Journal of infectious diseases.

[9]  L. Paitoonpong,et al.  Immunological response to hepatitis B vaccination in patients with AIDS and virological response to highly active antiretroviral therapy , 2008, Scandinavian journal of infectious diseases.

[10]  T. Lieu,et al.  Recommended adult immunization schedule: United States, October 2007-September 2008 , 2007 .

[11]  J. Kao,et al.  Evolution of hepatitis B serological markers in HIV-infected patients receiving highly active antiretroviral therapy. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  P. Tien,et al.  Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected women. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  L. Aurpibul,et al.  Antibody response to hepatitis B re-vaccination in HIV-infected children with immune recovery on highly active antiretroviral therapy. , 2007, Vaccine.

[14]  S. Shafran,et al.  Poor efficacy of intradermal administration of recombinant hepatitis B virus immunization in HIV‐infected individuals who fail to respond to intramuscular administration of hepatitis B virus vaccine , 2007, HIV medicine.

[15]  S. Sungkanuparph,et al.  Factors for predicting successful immune response to hepatitis B vaccination in HIV-1 infected patients. , 2007, The Southeast Asian journal of tropical medicine and public health.

[16]  S. Sungkanuparph,et al.  Isolated antibody to hepatitis B core antigen in HIV-1 infected patients and a pilot study of vaccination to determine the anamnestic response. , 2006, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[17]  A. Duarte,et al.  Humoral response to hepatitis B vaccination and its relationship with T CD45RA+ (naïve) and CD45RO+ (memory) subsets in HIV-1-infected subjects. , 2006, Vaccine.

[18]  M. Alter,et al.  A Comprehensive Immunization Strategy to Eliminate Transmission of Hepatitis B Virus Infection in the United States , 2006, Pediatrics.

[19]  E. Sagnelli,et al.  Impact of occult hepatitis B virus infection in HIV patients naive for antiretroviral therapy , 2006, AIDS.

[20]  G. Ruiz-Palacios,et al.  Randomized controlled trial of Hepatitis B virus vaccine in HIV-1-infected patients comparing two different doses , 2006, AIDS research and therapy.

[21]  Y. Chawla,et al.  Immune responses in patients with HIV infection after vaccination with recombinant Hepatitis B virus vaccine , 2006, BMC infectious diseases.

[22]  A. Zanetti,et al.  Long-term immunogenicity of hepatitis B vaccination and policy for booster: an Italian multicentre study , 2005, The Lancet.

[23]  W. Powderly,et al.  Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[24]  P. Sax,et al.  Response to hepatitis B vaccine in HIV-1-positive subjects who test positive for isolated antibody to hepatitis B core antigen: implications for hepatitis B vaccine strategies. , 2005, The Journal of infectious diseases.

[25]  A. Barone,et al.  Randomized trial of recombinant hepatitis B vaccine in HIV-infected adult patients comparing a standard dose to a double dose. , 2005, Vaccine.

[26]  N. Shire,et al.  Occult Hepatitis B in HIV-Infected Patients , 2004, Journal of acquired immune deficiency syndromes.

[27]  A. Moorman,et al.  Hepatitis A and B vaccination practices for ambulatory patients infected with HIV. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  I. D. de Messias-Reason,et al.  Efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant for hepatitis B virus in patients with HIV infection. , 2003, Vaccine.

[29]  A. McNaghten,et al.  Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virus-infected subjects. , 2003, The Journal of infectious diseases.

[30]  K. Leder,et al.  The effect of age on immunologic response to recombinant hepatitis B vaccine: a meta-analysis. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[31]  J. Peiris,et al.  Immunogenicity of Intradermal Hepatitis B Vaccination in Renal Transplant Recipients , 2002, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[32]  J. Phair,et al.  HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS) , 2002, The Lancet.

[33]  P. Hogan,et al.  Intradermal Recombinant Hepatitis B Vaccine for Healthcare Workers Who Fail to Respond to Intramuscular Vaccine , 2002, Infection Control & Hospital Epidemiology.

[34]  Recommended adult immunization schedule--United States, 2002-2003. , 2002, MMWR. Morbidity and mortality weekly report.

[35]  A. Sherker,et al.  The frequency and significance of isolated hepatitis B core antibody and the suggested management of patients. , 2001, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[36]  O. Ural,et al.  The response of isolated anti-HBc positive subjects to recombinant hepatitis B vaccine. , 2001, The Journal of infection.

[37]  J. Ellenberg,et al.  Serologic response to hepatitis B vaccine in HIV infected and high-risk HIV uninfected adolescents in the REACH cohort. Reaching for Excellence in Adolescent Care and Health. , 2001, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[38]  H. Margolis,et al.  Serological pattern “anti‐HBc alone”: Report on a workshop , 2000, Journal of medical virology.

[39]  J. Lang,et al.  Increasing the number of hepatitis B vaccine injections augments anti-HBs response rate in HIV-infected patients. Effects on HIV-1 viral load. , 2000, Vaccine.

[40]  M. Loriot,et al.  Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men , 1999, Hepatology.

[41]  R. Tedder,et al.  Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection , 1997, AIDS.

[42]  B. Donovan,et al.  Response to hepatitis B vaccination in a primary care setting: influence of HIV infection, CD4+ lymphocyte count and vaccination schedule. , 1996, International journal of STD & AIDS.

[43]  R. Ellison,et al.  Hepatitis B vaccination and plasma HIV-1 RNA. , 1996, The New England journal of medicine.

[44]  B. Cooper,et al.  Immunization with high-dose intradermal recombinant hepatitis B vaccine in healthcare workers who failed to respond to intramuscular vaccination. , 1995, Infection control and hospital epidemiology.

[45]  B. McMahon,et al.  Response to hepatitis B vaccine of persons positive for antibody to hepatitis B core antigen. , 1992, Gastroenterology.

[46]  S. Hadler,et al.  Outcome of hepatitis B virus infection in homosexual men and its relation to prior human immunodeficiency virus infection. , 1991, The Journal of infectious diseases.

[47]  H. Handsfield,et al.  Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination. , 1988, Annals of internal medicine.

[48]  Ching-lung Lai,et al.  Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: Implications in hepatitis B vaccination programs , 1988, Hepatology.

[49]  S. Hadler,et al.  Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men. , 1986, The New England journal of medicine.

[50]  C. Crumpacker,et al.  Hepatitis B vaccine in health care personnel: safety, immunogenicity, and indicators of efficacy. , 1984, Annals of internal medicine.

[51]  W. Szmuness,et al.  Hepatitis B vaccine in medical staff of hemodialysis units: efficacy and subtype cross-protection. , 1982, The New England journal of medicine.