N3-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU
暂无分享,去创建一个
W. Liu | Zu-hua Gao | Xian-Jun Qu | Wenfang Xu | X. Xue | J. Zhong | Cui-rong Zhao | Xiaofan Zhang | Pan Yue | Limei Wang
[1] J. Schellens,et al. A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma. , 2009, Biomedical chromatography : BMC.
[2] Hermes Licea-Perez,et al. Development of a sensitive and selective LC-MS/MS method for the determination of alpha-fluoro-beta-alanine, 5-fluorouracil and capecitabine in human plasma. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[3] L. Fazli,et al. Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy , 2009, Cancer Chemotherapy and Pharmacology.
[4] K. Kurashina,et al. Comparison of alternate-day versus consecutive-day treatment with S-1: assessment of tumor growth inhibition and toxicity reduction in gastric cancer cell lines in vitro and in vivo , 2008, International Journal of Clinical Oncology.
[5] T. Shirasaka. Development History and Concept of an Oral Anticancer Agent S-1 (TS-1®): Its Clinical Usefulness and Future Vistas , 2008, Japanese journal of clinical oncology.
[6] Zhirong Zhang,et al. In vitro cytotoxicity, in vivo biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[7] Ming-Hui Chen,et al. Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity , 2008, Anti-cancer drugs.
[8] E. Alba,et al. A carboxylesterase 2 gene polymorphism as predictor of capecitabine on response and time to progression. , 2008, Current drug metabolism.
[9] N. Zhang,et al. Preparation and evaluation of N(3)-O-toluyl-fluorouracil-loaded liposomes. , 2008, International journal of pharmaceutics.
[10] M. Makuuchi,et al. Inhibition of human gastric carcinoma cell growth by treatment of N(3)-o-toluyl-fluorouracil as a precursor of 5-fluorouracil. , 2007, European journal of pharmacology.
[11] K. Caca,et al. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride , 2007, Cancer Chemotherapy and Pharmacology.
[12] M. Makuuchi,et al. Inhibition of human gastric carcinoma cell growth by atofluding derivative N3-o-toluyl-fluorouracil. , 2006, World Journal of Gastroenterology.
[13] J. Verweij,et al. A pharmacokinetic interaction study of docetaxel and cisplatin plus or minus 5-fluorouracil in the treatment of patients with recurrent or metastatic solid tumors , 2006, Cancer Chemotherapy and Pharmacology.
[14] E. Richardet,et al. Irinotecan, Oxaliplatin Plus Bolus 5-Fluorouracil and Low Dose Folinic Acid Every 2 Weeks: A Feasibility Study in Metastatic Colorectal Cancer Patients , 2006, American journal of clinical oncology.
[15] H. Lenz,et al. Should Continuous Infusion 5-Fluorouracil Become the Standard of Care in the USA as It Is in Europe? , 2006, Cancer investigation.
[16] S. Guichard,et al. Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[17] R. Nave,et al. Identification of enzymes involved in Phase I metabolism of ciclesonide by human liver microsomes , 2005, European Journal of Drug Metabolism and Pharmacokinetics.
[18] M. Das,et al. Mechanism to study 1:1 stoichiometry of NADPH and alkoxyphenoxazones metabolism spectrophotometrically in subcellular biological preparations. , 2004, Biochimica et biophysica acta.
[19] S. Tokudome,et al. IDENTIFICATION OF THE CYTOSOLIC CARBOXYLESTERASE CATALYZING THE 5′-DEOXY-5-FLUOROCYTIDINE FORMATION FROM CAPECITABINE IN HUMAN LIVER , 2004, Drug Metabolism and Disposition.
[20] N. Funata,et al. Modulation of thymidine phosphorylase by neoadjuvant chemotherapy in primary breast cancer , 2004, British Journal of Cancer.
[21] Yang Zhang,et al. [Phase III clinical study of a new anticancer drug atofluding]. , 2002, Ai zheng = Aizheng = Chinese journal of cancer.
[22] S. Ozawa,et al. Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver , 2002, Cancer Chemotherapy and Pharmacology.
[23] M. Das,et al. A novel approach to study the activity and stoichiometry simultaneously for microsomal pentoxyresorufin‐O‐dealkylase reaction , 2002, FEBS letters.
[24] W. Bubb,et al. Synthesis of 5-fluoropyrimidines , 1974 .
[25] C. Heidelberger,et al. THE SYNTHESIS OF 5-FLUOROPYRIMIDINES , 1957 .
[26] N. Zhang,et al. Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration. , 2008, Journal of drug targeting.