PHOTODYNAMIC INACTIVATION OF BACTERIA AND BIOFILMS USING CATIONIC BACTERIOCHLORINS

This work is devoted to the study of two new synthetic bacteriochlorins with four and eight cationic substitutes as the photosensitizers in the photodynamic process. The spectral and antibacterial properties of these photosensitizers in saline solution were investigated. It is shown, that the aggregation ability decreases and the antibacterial efficiency grows as the cationic substitute number increases.

[1]  S. Schastak,et al.  Efficient Photodynamic Therapy against Gram-Positive and Gram-Negative Bacteria Using THPTS, a Cationic Photosensitizer Excited by Infrared Wavelength , 2010, PloS one.

[2]  Michael R Hamblin,et al.  Stable Synthetic Cationic Bacteriochlorins as Selective Antimicrobial Photosensitizers , 2010, Antimicrobial Agents and Chemotherapy.

[3]  Y. Antonenko,et al.  Electrostatic binding of substituted metal phthalocyanines to enterobacterial cells: Its role in photodynamic inactivation , 2009, Biochemistry (Moscow).

[4]  N. Kuznetsova,et al.  Effects of the degree of substitution on the physicochemical properties and photodynamic activity of zinc and aluminum phthalocyanine polycations , 2009 .

[5]  Joseph O Matu,et al.  Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. , 2009, Trends in microbiology.

[6]  S. Schastak,et al.  Improved photoinactivation of gram-negative and gram-positive methicillin-resistant bacterial strains using a new near-infrared absorbing meso-tetrahydroporphyrin: a comparative study with a chlorine e6 photosensitizer photolon. , 2008, Methods and findings in experimental and clinical pharmacology.

[7]  Michael R Hamblin,et al.  Photodynamic therapy: a new antimicrobial approach to infectious disease? , 2004, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[8]  Stanley B. Brown,et al.  Photosensitized inactivation of microorganisms , 2004, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[9]  J. Costerton,et al.  Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms , 2002, Clinical Microbiology Reviews.

[10]  J. E. Lier,et al.  Sulfonated Phthalocyanines: Photophysical Properties, in vitro Cell Uptake and Structure-activity Relationships , 1998 .

[11]  J. H. Parish,et al.  Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria. , 1996, Journal of photochemistry and photobiology. B, Biology.

[12]  A. D. Mello,et al.  PHTHALOCYANINE FLUORESCENCE AT HIGH CONCENTRATION: DIMERS OR REABSORPTION EFFECT? , 1995 .

[13]  J Moan,et al.  Evaluation of a new photosensitizer, meso‐tetra‐hydroxyphenyl‐chlorin, for use in photodynamic therapy: A comparison of its photobiological properties with those of two other photosensitizers , 1994, International journal of cancer.

[14]  Z. Malik,et al.  Photodynamic inactivation of Gram-negative bacteria: problems and possible solutions. , 1992, Journal of photochemistry and photobiology. B, Biology.