Contents lists available at ScienceDirect Neuroscience Letters

Evidence suggests that the neural system associated with face processing is a distributed cortical network containing both bottom-up and top-down mechanisms. While bottom-up face processing has been the focus of many studies, the neural areas involved in the top-down face processing have not been extensively investigated due to difficulty in isolating top-down influences from the bottom-up response engendered by presentation of a face. In the present study, we used a novel experimental method to induce illusory face-detection. This method allowed for directly examining the neural systems involved in top-down face processing while minimizing the influence of bottom-up perceptual input. A distributed cortical network of top-down face processing was identified by analyzing the functional connectivity patterns of istributed cortical network

[1]  T. Südhof,et al.  rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Thomas C. Südhof,et al.  The role of Rab3A in neurotransmitter release , 1994, Nature.

[3]  S. Rauch,et al.  Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression , 1996, Neuron.

[4]  Leslie G. Ungerleider,et al.  Face encoding and recognition in the human brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Thomas C. Südhof,et al.  Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion , 1997, Nature.

[6]  Karl J. Friston,et al.  Psychophysiological and Modulatory Interactions in Neuroimaging , 1997, NeuroImage.

[7]  N. Kanwisher,et al.  The Fusiform Face Area: A Module in Human Extrastriate Cortex Specialized for Face Perception , 1997, The Journal of Neuroscience.

[8]  H. Horvitz,et al.  Caenorhabditis elegans rab-3 Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles , 1997, The Journal of Neuroscience.

[9]  M. Tarr,et al.  Activation of the middle fusiform 'face area' increases with expertise in recognizing novel objects , 1999, Nature Neuroscience.

[10]  K. Nakayama,et al.  RESPONSE PROPERTIES OF THE HUMAN FUSIFORM FACE AREA , 2000, Cognitive neuropsychology.

[11]  G. Baldini,et al.  Rab3A and Rab3D Control the Total Granule Number and the Fraction of Granules Docked at the Plasma Membrane in PC12 Cells , 2000, Traffic.

[12]  J. Haxby,et al.  The distributed human neural system for face perception , 2000, Trends in Cognitive Sciences.

[13]  A. Ishai,et al.  Distributed neural systems for the generation of visual images , 2000, NeuroImage.

[14]  Mark S. Seidenberg,et al.  Neural Systems Underlying the Recognition of Familiar and Newly Learned Faces , 2000, The Journal of Neuroscience.

[15]  G. Schiavo,et al.  Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin* , 2001, The Journal of Biological Chemistry.

[16]  F. H. Lopes da Silva,et al.  Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. , 2001, Molecular biology of the cell.

[17]  Erik M. Jorgensen,et al.  A post-docking role for active zone protein Rim , 2001, Nature Neuroscience.

[18]  E. Rolls,et al.  Abstract reward and punishment representations in the human orbitofrontal cortex , 2001, Nature Neuroscience.

[19]  E. Jorgensen,et al.  An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming , 2001, Nature.

[20]  A. Dale,et al.  Dorsal anterior cingulate cortex: A role in reward-based decision making , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. D’Esposito,et al.  Medial Temporal Lobe Activity Associated with Active Maintenance of Novel Information , 2001, Neuron.

[22]  T. Südhof,et al.  RIM1alpha is required for presynaptic long-term potentiation. , 2002, Nature.

[23]  Leslie G. Ungerleider,et al.  Visual Imagery of Famous Faces: Effects of Memory and Attention Revealed by fMRI , 2002, NeuroImage.

[24]  Thomas C. Südhof,et al.  RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone , 2002, Nature.

[25]  M. Seghier,et al.  A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing. , 2003, Brain : a journal of neurology.

[26]  J. Grafman,et al.  The Human Amygdala: An Evolved System for Relevance Detection , 2003, Reviews in the neurosciences.

[27]  M. Bar A Cortical Mechanism for Triggering Top-Down Facilitation in Visual Object Recognition , 2003, Journal of Cognitive Neuroscience.

[28]  Thomas C. Südhof,et al.  Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses , 2003, Cell.

[29]  M. Fukuda Alternative splicing in the first α‐helical region of the Rab‐binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution? , 2004, Genes to cells : devoted to molecular & cellular mechanisms.

[30]  Klaas Enno Stephan,et al.  On the role of general system theory for functional neuroimaging , 2004, Journal of anatomy.

[31]  Karl J. Friston,et al.  Where bottom-up meets top-down: neuronal interactions during perception and imagery. , 2004, Cerebral cortex.

[32]  Leslie G. Ungerleider,et al.  Repetition suppression of faces is modulated by emotion. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[33]  T. Südhof,et al.  A Complete Genetic Analysis of Neuronal Rab3 Function , 2004, The Journal of Neuroscience.

[34]  Thomas C. Südhof,et al.  Multiple Roles for the Active Zone Protein RIM1α in Late Stages of Neurotransmitter Release , 2004, Neuron.

[35]  Mark D'Esposito,et al.  Searching for “the Top” in Top-Down Control , 2005, Neuron.

[36]  Conny F. Schmidt,et al.  Face perception is mediated by a distributed cortical network , 2005, Brain Research Bulletin.

[37]  Kathryn M. McMillan,et al.  N‐back working memory paradigm: A meta‐analysis of normative functional neuroimaging studies , 2005, Human brain mapping.

[38]  Ralf Schneggenburger,et al.  A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? , 2005, The EMBO journal.

[39]  M. Nonet,et al.  Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans , 2006, PLoS biology.

[40]  E. Halgren,et al.  Top-down facilitation of visual recognition. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Timothy E. J. Behrens,et al.  Optimal decision making and the anterior cingulate cortex , 2006, Nature Neuroscience.

[42]  Alumit Ishai,et al.  Face Perception Is Modulated by Sexual Preference , 2006, Current Biology.

[43]  R. Weimer,et al.  Preservation of C. elegans tissue via high-pressure freezing and freeze-substitution for ultrastructural analysis and immunocytochemistry. , 2006, Methods in molecular biology.

[44]  Michael Angstadt,et al.  Beyond threat: Amygdala reactivity across multiple expressions of facial affect , 2006, NeuroImage.

[45]  Mitsunori Fukuda,et al.  Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells , 2006, Journal of Cell Science.

[46]  J. Bessereau,et al.  UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains , 2006, The Journal of Neuroscience.

[47]  Timothy R Mahoney,et al.  Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. , 2006, Molecular biology of the cell.

[48]  Kenneth F. Valyear,et al.  The fusiform face area is not sufficient for face recognition: Evidence from a patient with dense prosopagnosia and no occipital face area , 2006, Neuropsychologia.

[49]  F. Varoqueaux,et al.  Binding to Rab3A-interacting Molecule RIM Regulates the Presynaptic Recruitment of Munc13-1 and ubMunc13-2* , 2006, Journal of Biological Chemistry.

[50]  N. Kanwisher,et al.  The fusiform face area: a cortical region specialized for the perception of faces , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[51]  Jennifer A. Mangels,et al.  Predictive Codes for Forthcoming Perception in the Frontal Cortex , 2006, Science.

[52]  T. Südhof,et al.  Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-Term Synaptic Plasticity , 2006, The Journal of Neuroscience.

[53]  Tobias Egner,et al.  Cerebral Cortex doi:10.1093/cercor/bhi129 Mistaking a House for a Face: Neural Correlates of Misperception in Healthy Humans , 2005 .

[54]  J. Haxby,et al.  Neural systems for recognition of familiar faces , 2007, Neuropsychologia.

[55]  Aaron M. Beedle,et al.  RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels , 2007, Nature Neuroscience.

[56]  Timothy E. J. Behrens,et al.  Adaptive decision making and value in the anterior cingulate cortex , 2007, NeuroImage.

[57]  M. Bar,et al.  Magnocellular Projections as the Trigger of Top-Down Facilitation in Recognition , 2007, The Journal of Neuroscience.

[58]  M. Bar,et al.  Top-down predictions in the cognitive brain , 2007, Brain and Cognition.

[59]  Marcia K. Johnson,et al.  A brief thought can modulate activity in extrastriate visual areas: Top-down effects of refreshing just-seen visual stimuli , 2007, NeuroImage.

[60]  A. Ishai,et al.  Effective connectivity within the distributed cortical network for face perception. , 2007, Cerebral cortex.

[61]  M. Verhage,et al.  The Role of Rab3a in Secretory Vesicle Docking Requires Association/Dissociation of Guanidine Phosphates and Munc18-1 , 2007, PloS one.

[62]  W. L. Coleman,et al.  Rab3a deletion reduces vesicle docking and transmitter release at the mouse diaphragm synapse , 2007, Neuroscience.

[63]  Alumit Ishai,et al.  Sex, beauty and the orbitofrontal cortex. , 2007, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[64]  Jie Tian,et al.  BRAIN IMAGING NEUROREPORT , 2007 .

[65]  Alumit Ishai,et al.  Let’s face it: It’s a cortical network , 2008, NeuroImage.

[66]  Lutz Jäncke,et al.  Feeling Present in Arousing Virtual Reality Worlds: Prefrontal Brain Regions Differentially Orchestrate Presence Experience in Adults and Children , 2008, Frontiers in human neuroscience.

[67]  Jie Tian,et al.  Similarities in neural activations of face and Chinese character discrimination , 2009, Neuroreport.