Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms.

[1]  M. Zern,et al.  Delivery of antioxidative enzyme genes protects against ischemia/reperfusion–induced liver injury in mice , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[2]  A. Wullaert,et al.  Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. , 2006, Biochemical pharmacology.

[3]  Y. Tsao,et al.  Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells , 2006, Apoptosis.

[4]  C. Qian,et al.  Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. , 2006, Cancer research.

[5]  Yoshio Miki,et al.  Protein Kinase C δ Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage* , 2006, Journal of Biological Chemistry.

[6]  S. Marsigliante,et al.  Protein kinase C (PKC)-δ/-ε mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin , 2006 .

[7]  M. Nitti,et al.  4-Hydroxynonenal signalling to apoptosis in isolated rat hepatocytes: the role of PKC-delta. , 2005, Biochimica et biophysica acta.

[8]  A. Santiago-Walker,et al.  Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest* , 2005, Journal of Biological Chemistry.

[9]  S. Hill,et al.  Trypsin stimulates the phosphorylation of p42,44 mitogen‐activated protein kinases via the proteinase‐activated receptor‐2 and protein kinase C epsilon in human cultured prostate stromal cells , 2005, The Prostate.

[10]  Y. Kohda,et al.  Cephaloridine induces translocation of protein kinase C delta into mitochondria and enhances mitochondrial generation of free radicals in the kidney cortex of rats causing renal dysfunction. , 2005, Journal of pharmacological sciences.

[11]  Misuk Kang,et al.  Protein kinase C δ and ε mediate positive inotropy in adult ventricular myocytes , 2005 .

[12]  M. J. Atten,et al.  Resveratrol regulates cellular PKC α and δ to inhibit growth and induce apoptosis in gastric cancer cells , 2005, Investigational New Drugs.

[13]  S. Shukla,et al.  Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. , 2005, European journal of pharmacology.

[14]  S. Steinberg Distinctive activation mechanisms and functions for protein kinase Cdelta. , 2004, The Biochemical journal.

[15]  H. Matsuzaki,et al.  Ceramide-induced Apoptosis by Translocation, Phosphorylation, and Activation of Protein Kinase Cδ in the Golgi Complex* , 2004, Journal of Biological Chemistry.

[16]  S. Shukla,et al.  MAP kinase signaling in diverse effects of ethanol. , 2004, Life sciences.

[17]  P. Blumberg,et al.  Regulation of cell apoptosis by protein kinase c δ , 2004, Apoptosis.

[18]  M. Kitazawa,et al.  Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. , 2003, Antioxidants & redox signaling.

[19]  I. Weinstein,et al.  Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes* , 2003, Journal of Biological Chemistry.

[20]  B. H. Shah,et al.  Activation and nuclear translocation of PKCδ, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells , 2003, The Journal of Steroid Biochemistry and Molecular Biology.

[21]  N. Hah,et al.  An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. , 2003, Biochemical and biophysical research communications.

[22]  S. Shukla,et al.  Phosphotidylethanol mimics ethanol modulation of p42/44 mitogen-activated protein kinase signalling in hepatocytes. , 2002, Alcohol and alcoholism.

[23]  A. Kong,et al.  Antioxidants and oxidants regulated signal transduction pathways. , 2002, Biochemical pharmacology.

[24]  M. Kitazawa,et al.  Caspase-3-dependent Proteolytic Cleavage of Protein Kinase C␦ Is Essential for Oxidative Stress-mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl , 2022 .

[25]  P. Blumberg,et al.  Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide , 2002, Molecular and Cellular Biology.

[26]  C. Scheidereit,et al.  B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's , 2001, Molecular and Cellular Biology.

[27]  Y. Nishizuka,et al.  Phosphorylation sites of protein kinase C δ in H2O2-treated cells and its activation by tyrosine kinase in vitro , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  G. Gores,et al.  Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. , 2001, Journal of hepatology.

[29]  L. Carpenter,et al.  Protein Kinase Cδ Activation by Interleukin-1β Stabilizes Inducible Nitric-oxide Synthase mRNA in Pancreatic β-Cells* , 2000, The Journal of Biological Chemistry.

[30]  B. Webb,et al.  Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis , 2000, British journal of pharmacology.

[31]  J. Hoek,et al.  Roles of Tissue Transglutaminase in Ethanol-induced Inhibition of Hepatocyte Proliferation and α1-Adrenergic Signal Transduction* , 2000, The Journal of Biological Chemistry.

[32]  P. Majumder,et al.  Mitochondrial Translocation of Protein Kinase C δ in Phorbol Ester-induced Cytochrome c Release and Apoptosis* , 2000, The Journal of Biological Chemistry.

[33]  J. Lord,et al.  PKC-δ is an apoptotic lamin kinase , 2000, Oncogene.

[34]  S. Anderson,et al.  Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells* , 1999, The Journal of Biological Chemistry.

[35]  K. Shimamatsu,et al.  Role of ischemia in causing apoptosis, atrophy, and nodular hyperplasia in human liver , 1997, Hepatology.

[36]  H. Saito,et al.  Oxidative stress‐mediated apoptosis of hepatocytes exposed to acute ethanol intoxication , 1997, Hepatology.

[37]  S. Ratnofsky,et al.  Proteolytic Activation of Protein Kinase C ␦ by an Ice/ced 3-like Protease Induces Characteristics of Apoptosis Materials and Methods , 1996 .

[38]  J. Boyer,et al.  Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. , 1996, Gastroenterology.

[39]  M. Zern,et al.  Vitamin E therapy of acute CCl4‐induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding , 1995, Hepatology.