The 'evolvability' of promiscuous protein functions

[1]  U. Bornscheuer,et al.  Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways. , 2004, Angewandte Chemie.

[2]  M. Lynch,et al.  The altered evolutionary trajectories of gene duplicates. , 2004, Trends in genetics : TIG.

[3]  B. Katzenellenbogen,et al.  Directed Evolution of Human Estrogen Receptor Variants with Significantly Enhanced Androgen Specificity and Affinity* , 2004, Journal of Biological Chemistry.

[4]  T. Steitz,et al.  Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors , 2004 .

[5]  T. Steitz,et al.  Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[6]  David J. Earl,et al.  Evolvability is a selectable trait. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[7]  W. Metcalf,et al.  A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Raines,et al.  Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. , 2004, Biochemistry.

[9]  Dan S. Tawfik,et al.  Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes , 2004, Nature Structural &Molecular Biology.

[10]  A. Radeghieri,et al.  Expanding the substrate repertoire of a DNA polymerase by directed evolution. , 2004, Journal of the American Chemical Society.

[11]  Dan S. Tawfik,et al.  Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Jie Yang,et al.  Creation of the first anomeric D/L-sugar kinase by means of directed evolution. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Dan S. Tawfik,et al.  The specificity of cross‐reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness , 2003, Protein science : a publication of the Protein Society.

[14]  Ke Liu,et al.  A despecialization step underlying evolution of a family of serine proteases. , 2003, Molecular cell.

[15]  Dan S. Tawfik,et al.  Conformational diversity and protein evolution--a 60-year-old hypothesis revisited. , 2003, Trends in biochemical sciences.

[16]  A. Fersht,et al.  Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  S. Copley.  Enzymes with extra talents: moonlighting functions and catalytic promiscuity. , 2003, Current opinion in chemical biology.

[18]  J. Oakeshott,et al.  Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution. , 2003, Protein engineering.

[19]  Dan S. Tawfik,et al.  Antibody Multispecificity Mediated by Conformational Diversity , 2003, Science.

[20]  Frances H. Arnold,et al.  Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase , 2002, Nature Biotechnology.

[21]  Richard A Goldstein,et al.  Why are proteins so robust to site mutations? , 2002, Journal of molecular biology.

[22]  Dan S. Tawfik,et al.  Catalytic and binding poly‐reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution , 2001, Protein science : a publication of the Protein Society.

[23]  C. Schmidt-Dannert,et al.  Conversion of Bacillus thermocatenulatus lipase into an efficient phospholipase with increased activity towards long-chain fatty acyl substrates by directed evolution and rational design. , 2001, Protein engineering.

[24]  J. Dordick,et al.  Generation of a broad esterolytic subtilisin using combined molecular evolution and periplasmic expression. , 2001, Protein engineering.

[25]  Frank Buchholz,et al.  Alteration of Cre recombinase site specificity by substrate-linked protein evolution , 2001, Nature Biotechnology.

[26]  J. Seffernick,et al.  Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes. , 2001, Chemistry & biology.

[27]  F. Taddei,et al.  Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse Gut , 2001, Science.

[28]  F. Arnold,et al.  How enzymes adapt: lessons from directed evolution , 2001, Trends in biochemical sciences.

[29]  A D Ellington,et al.  In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates. , 2001, Journal of molecular biology.

[30]  H. True,et al.  A yeast prion provides a mechanism for genetic variation and phenotypic diversity , 2000, Nature.

[31]  B. Mannervik,et al.  Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[32]  C. Saudan,et al.  Directed molecular evolution of cytochrome c peroxidase. , 2000, Biochemistry.

[33]  H. Jakubowski.  Calcium-dependent Human Serum Homocysteine Thiolactone Hydrolase , 2000, The Journal of Biological Chemistry.

[34]  F. Taddei,et al.  Evolution of Evolvability a , 1999 .

[35]  D. Herschlag,et al.  Catalytic promiscuity and the evolution of new enzymatic activities. , 1999, Chemistry & biology.

[36]  A. Mauk,et al.  In vitro evolution of horse heart myoglobin to increase peroxidase activity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[37]  H. Suenaga,et al.  Enhanced degradation of polychlorinated biphenyls by directed evolution of biphenyl dioxygenase , 1998, Nature Biotechnology.

[38]  C. Craik,et al.  Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold* , 1997, The Journal of Biological Chemistry.

[39]  D. M. Brown,et al.  An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues. , 1996, Journal of molecular biology.

[40]  W. Stemmer.  DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[41]  C. Fierke,et al.  Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. , 1993, The Journal of biological chemistry.

[42]  David A. Agard,et al.  Structural plasticity broadens the specificity of an engineered protease , 1989, Nature.

[43]  R. Khalifah,et al.  The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. , 1971, The Journal of biological chemistry.

[44]  A. Giraud.  Adaptive Evolution of Bacteria in the Mouse Gut Costs and Benefits of High Mutation Rates , 2007 .

[45]  C. K. Chu,et al.  Understanding the molecular mechanism of drug resistance of anti-HIV nucleosides by molecular modeling. , 2004, Frontiers in bioscience : a journal and virtual library.

[46]  B. La Du,et al.  Pharmacogenetics of paraoxonases: a brief review , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[47]  Jeremy Minshull,et al.  Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily. , 2003, Biochemistry.

[48]  F. Raushel,et al.  Phosphotriesterase: an enzyme in search of its natural substrate. , 2000, Advances in enzymology and related areas of molecular biology.

[49]  J. Hörandel,et al.  COSMIC RAYS FROM THE KNEE TO THE SECOND , 2007 .

[50]  Richard Dawkins,et al.  The Evolution of Evolvability , 1987, ALIFE.

[51]  R. Jensen.  Enzyme recruitment in evolution of new function. , 1976, Annual review of microbiology.