Update on Ultrasound Techniques for the Diagnosis of Cerebral Ischemia

Ultrasound (US) techniques increase the ability of neurologists specializing in stroke to rapidly evaluate stroke patients, determine likely mechanisms of brain ischemia, determine arterial patency, quantify stenosis severity, and determine the most appropriate clinical management. Furthermore, the development of new US techniques based on the detection of US contrast agents may permit the evaluation of cerebral microcirculation and the identification of regions of angiogenesis, inflammation and thrombus during brain ischemia.

[1]  A. Alexandrov,et al.  Residual Flow at the Site of Intracranial Occlusion on Transcranial Doppler Predicts Response to Intravenous Thrombolysis: A Multi-Center Study , 2008, Cerebrovascular Diseases.

[2]  A. Alexandrov,et al.  Quantification of Microspheres Appearance in Brain Vessels: Implications for Residual Flow Velocity Measurements, Dose Calculations, and Potential Drug Delivery , 2008, Stroke.

[3]  A. Alexandrov,et al.  Design of a Prospective Multi-National CLOTBUST Collaboration on Reperfusion Therapies for Stroke , 2008, International journal of stroke : official journal of the International Stroke Society.

[4]  A. Alexandrov,et al.  Transcranial Ultrasound in Acute Stroke: From Diagnosis to Therapy , 2007, Cerebrovascular Diseases.

[5]  A. Alexandrov,et al.  Validation of Transcranial Doppler With Computed Tomography Angiography in Acute Cerebral Ischemia , 2007, Stroke.

[6]  Zsolt Garami,et al.  Site of Arterial Occlusion Identified by Transcranial Doppler Predicts the Response to Intravenous Thrombolysis for Stroke , 2007, Stroke.

[7]  A. Alexandrov,et al.  Clinical Deterioration After Intravenous Recombinant Tissue Plasminogen Activator Treatment: A Multicenter Transcranial Doppler Study , 2007, Stroke.

[8]  A. Alexandrov,et al.  Derivation of Power M‐Mode Transcranial Doppler Criteria for Angiographic Proven MCA Occlusion , 2006, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[9]  A. Naylor.  Early carotid endarterectomy after ischemic stroke: the results of a prospective multicenter Italian study. , 2006, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[10]  T. Landis,et al.  Combined IV–intra-arterial thrombolysis: A color-coded duplex pilot study , 2006, Neurology.

[11]  K. Lovblad,et al.  Intravenous Versus Combined (Intravenous and Intra-Arterial) Thrombolysis in Acute Ischemic Stroke: A Transcranial Color-Coded Duplex Sonography–Guided Pilot Study , 2006, Stroke.

[12]  J. Wardlaw,et al.  Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis , 2006, The Lancet.

[13]  F. Purroy,et al.  Efectividad del estudio ultrasonográfico precoz en el pronóstico a corto plazo de los pacientes con un accidente vascular cerebral isquémico transitorio , 2006 .

[14]  S. Momjian,et al.  Correlation of Cerebrovascular Symptoms and Microembolic Signals With the Stratified Gray-Scale Median Analysis and Color Mapping of the Carotid Plaque , 2006, Stroke.

[15]  W. Irwin,et al.  Duplex ultrasonography of vertebral and subclavian arteries. , 2005, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[16]  A. Alexandrov,et al.  Transcranial Doppler in acute stroke. , 2005, Neuroimaging clinics of North America.

[17]  J. Arenillas,et al.  Predictors of Early Arterial Reocclusion After Tissue Plasminogen Activator-Induced Recanalization in Acute Ischemic Stroke , 2005, Stroke.

[18]  A. Demchuk,et al.  Derivation of Transcranial Doppler Criteria for Rescue Intra-arterial Thrombolysis: Multicenter Experience From the Interventional Management of Stroke Study , 2005, Stroke.

[19]  Hashem Shaltoni,et al.  Yield and Accuracy of Urgent Combined Carotid/Transcranial Ultrasound Testing in Acute Cerebral Ischemia , 2005, Stroke.

[20]  A. Alexandrov,et al.  Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. , 2004, The New England journal of medicine.

[21]  H. Naritomi,et al.  Transcranial color-coded real-time sonographic criteria for occlusion of the middle cerebral artery in acute ischemic stroke. , 2004, AJNR. American journal of neuroradiology.

[22]  P. Rothwell,et al.  Histological Correlates of Carotid Plaque Surface Morphology on Lumen Contrast Imaging , 2004, Circulation.

[23]  A. Nicolaides,et al.  Carotid Plaque Echolucency Increases the Risk of Stroke in Carotid Stenting: The Imaging in Carotid Angioplasty and Risk of Stroke (ICAROS) Study , 2004, Circulation.

[24]  Achim Gass,et al.  Ultrasound Microbubble Destruction Imaging in Acute Middle Cerebral Artery Stroke , 2004, Stroke.

[25]  W Wilkening,et al.  Detection of cerebral perfusion abnormalities in acute stroke using phase inversion harmonic imaging (PIHI): preliminary results , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[26]  Til Aach,et al.  Ultrasound Perfusion Imaging in Acute Middle Cerebral Artery Infarction Predicts Outcome , 2004, Stroke.

[27]  M. Wiesmann,et al.  Parametric Perfusion Imaging With Contrast-Enhanced Ultrasound in Acute Ischemic Stroke , 2004, Stroke.

[28]  MartinWiesmann,et al.  Parametric Perfusion Imaging With Contrast-Enhanced Ultrasound in Acute Ischemic Stroke , 2004 .

[29]  A. Alexandrov,et al.  Improving the Predictive Accuracy of Recanalization on Stroke Outcome in Patients Treated With Tissue Plasminogen Activator , 2003, Stroke.

[30]  R Eugene Zierler,et al.  Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference. , 2003, Radiology.

[31]  Martin Wiesmann,et al.  Perfusion harmonic imaging in acute middle cerebral artery infarction. , 2003, Ultrasound in medicine & biology.

[32]  M. Wiesmann,et al.  Harmonic Imaging in Acute Stroke: Detection of a Cerebral Perfusion Deficit With Ultrasound and Perfusion MRI , 2003, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[33]  Jonathan R. Lindner,et al.  Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to &agr;v-Integrins , 2003, Circulation.

[34]  J. Lindner.  Detection of inflamed plaques with contrast ultrasound. , 2002, The American journal of cardiology.

[35]  E. Unger,et al.  Targeted-Microbubble Binding Selectively to GPIIb IIIa Receptors of Platelet Thrombi , 2002, Investigative radiology.

[36]  M. Uchino,et al.  Combined carotid and transcranial color-coded sonography in acute ischemic stroke. , 2002, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[37]  M. Kaps,et al.  Sonographic harmonic grey scale imaging of brain perfusion: scope of a new method demonstrated in selected cases. , 2002, Ultraschall in der Medizin.

[38]  Paul A Dayton,et al.  Targeted imaging using ultrasound , 2002, Journal of magnetic resonance imaging : JMRI.

[39]  A. Alexandrov,et al.  Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator , 2002, Neurology.

[40]  William R. Wagner,et al.  Modulating Targeted Adhesion of an Ultrasound Contrast Agent to Dysfunctional Endothelium , 2002, Annals of Biomedical Engineering.

[41]  A. Alexandrov,et al.  Intracranial balloon angioplasty of acute terminal internal carotid artery occlusions. , 2002, AJNR. American journal of neuroradiology.

[42]  S. Kaul,et al.  Noninvasive Imaging of Myocardial Reperfusion Injury Using Leukocyte-Targeted Contrast Echocardiography , 2002, Circulation.

[43]  S. Pochon,et al.  In vivo ultrasound imaging of thrombi using a target-specific contrast agent. , 2002, Academic radiology.

[44]  S. Kownator,et al.  Benefits of Cerebral Protection during Carotid Stenting with the PercuSurge GuardWire System: Midterm Results , 2002, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.

[45]  C. Tegeler,et al.  Comparison of Transcranial Color‐Coded Sonography and Magnetic Resonance Angiography in Acute Ischemic Stroke , 2001, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[46]  A. Alexandrov,et al.  Arterial status after intravenous TPA therapy for ischaemic stroke. A need for further interventions. , 2001, International angiology : a journal of the International Union of Angiology.

[47]  G. Seidel,et al.  Evaluation of blood flow in the cerebral microcirculation: analysis of the refill kinetics during ultrasound contrast agent infusion. , 2001, Ultrasound in medicine & biology.

[48]  A. Alexandrov,et al.  Speed of Intracranial Clot Lysis With Intravenous Tissue Plasminogen Activator Therapy: Sonographic Classification and Short-Term Improvement , 2001, Circulation.

[49]  O. Joakimsen,et al.  Echolucent Plaques Are Associated With High Risk of Ischemic Cerebrovascular Events in Carotid Stenosis: The Tromsø Study , 2001, Circulation.

[50]  A. Alexandrov,et al.  Thrombolysis in Brain Ischemia (TIBI) Transcranial Doppler Flow Grades Predict Clinical Severity, Early Recovery, and Mortality in Patients Treated With Intravenous Tissue Plasminogen Activator , 2001, Stroke.

[51]  W Wilkening,et al.  Contrast Agent Specific Imaging Modes for the Ultrasonic Assessment of Parenchymal Cerebral Echo Contrast Enhancement , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[52]  A. Ahuja,et al.  Use of Transcranial Doppler Ultrasound to Predict Outcome in Patients With Intracranial Large-Artery Occlusive Disease , 2000, Stroke.

[53]  H. Przuntek,et al.  Ultrasonic evaluation of pathological brain perfusion in acute stroke using second harmonic imaging , 2000, Journal of neurology, neurosurgery, and psychiatry.

[54]  H. Becher,et al.  Stimulated acoustic emission detected by transcranial color doppler ultrasound : a contrast-specific phenomenon useful for the detection of cerebral tissue perfusion. , 2000, Stroke.

[55]  A. Alexandrov,et al.  Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke. , 2000, Stroke.

[56]  M. Ziskin,et al.  International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine. , 2000, Ultrasound in medicine & biology.

[57]  P. Rothwell,et al.  Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group. , 2000, Stroke.

[58]  M. Hennerici,et al.  Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion , 2000, The Lancet.

[59]  A. Alexandrov,et al.  Accuracy and Criteria for Localizing Arterial Occlusion With Transcranial Doppler , 2000, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[60]  C. Warlow,et al.  Evidence of a chronic systemic cause of instability of atherosclerotic plaques , 2000, The Lancet.

[61]  A. Alexandrov,et al.  Evolution of Rapid Middle Cerebral Artery Recanalization During Intravenous Thrombolysis for Acute Ischemic Stroke , 1999 .

[62]  H. Przuntek,et al.  Contrast-enhanced transcranial color-coded sonography in acute hemispheric brain infarction. , 1999, Stroke.

[63]  H. Przuntek,et al.  Second harmonic imaging In acute middle cerebral artery infarction. Preliminary results. , 1999, Stroke.

[64]  M. Kaps,et al.  The influence of Doppler system settings on the clearance kinetics of different ultrasound contrast agents. , 1999, European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology.

[65]  H. Schumacher,et al.  Carotid endarterectomy and intracranial thrombolysis: simultaneous and staged procedures in ischemic stroke. , 1999, Journal of vascular surgery.

[66]  D. Hanley,et al.  TCD, MRA and MRI in acute cerebral ischemia , 1999, Acta neurologica Scandinavica.

[67]  H. Przuntek,et al.  Transient response harmonic imaging: an ultrasound technique related to brain perfusion. , 1998, Stroke.

[68]  W. Hacke,et al.  Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke. , 1998, Stroke.

[69]  S. Nakano,et al.  Direct percutaneous transluminal angioplasty for acute middle cerebral artery occlusion. , 1998, AJNR. American journal of neuroradiology.

[70]  P. Faries,et al.  Ex vivo human carotid artery bifurcation stenting: correlation of lesion characteristics with embolic potential. , 1998, Journal of vascular surgery.

[71]  C. Wallesch,et al.  Diagnostic impact and prognostic relevance of early contrast-enhanced transcranial color-coded duplex sonography in acute stroke. , 1998, Stroke.

[72]  J. Wilhjelm,et al.  Echo-lucency of computerized ultrasound images of carotid atherosclerotic plaques are associated with increased levels of triglyceride-rich lipoproteins as well as increased plaque lipid content. , 1998, Circulation.

[73]  P. Burns,et al.  Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents , 1997, 1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118).

[74]  A. Moody,et al.  Comparison of transcranial color-coded sonography and magnetic resonance angiography in acute stroke. , 1997, Stroke.

[75]  A. Nicolaides,et al.  Histological verification of computerised carotid plaque characterisation. , 1996, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[76]  P. Burns.  Harmonic imaging with ultrasound contrast agents. , 1996, Clinical radiology.

[77]  M Kaps,et al.  Potential and limitations of transcranial color-coded sonography in stroke patients. , 1995, Stroke.

[78]  T. Porter,et al.  Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles. Demonstration and potential mechanisms. , 1995, Circulation.

[79]  R. Aaslid,et al.  Transcranial color‐coded duplex sonography, magnetic resonance angiography, and computed tomography angiography: Methods, applications, advantages, and limitations , 1995, Journal of clinical ultrasound : JCU.

[80]  Allan J. Fox,et al.  Significance of Plaque Ulceration in Symptomatic Patients With High‐Grade Carotid Stenosis , 1994, Stroke.

[81]  B. Censori,et al.  Transcranial doppler in acute ischemic stroke of the middle cerebral artery territories , 1993, Acta neurologica Scandinavica.

[82]  D. Sackett,et al.  Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. , 1991, The New England journal of medicine.

[83]  J. Ley-Pozo,et al.  Noninvasive detection of occlusive disease of the carotid siphon and middle cerebral artery , 1990, Annals of neurology.

[84]  M. Kaps,et al.  Transcranial Doppler ultrasound findings in middle cerebral artery occlusion. , 1990, Stroke.

[85]  G. Lenzi,et al.  Comparison of cerebral angiography and transcranial Doppler sonography in acute stroke. , 1989, Stroke.

[86]  H. Mattle,et al.  Transcranial Doppler sonographic findings in middle cerebral artery disease. , 1988, Archives of neurology.

[87]  R. Aaslid,et al.  Evaluation of cerebrovascular disease by combined extracranial and transcranial Doppler sonography. Experience in 1,039 patients. , 1987, Stroke.

[88]  R. Aaslid,et al.  Doppler diagnosis of intracranial artery occlusive disorders. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[89]  J. Arenillas,et al.  [Usefulness of urgent combined carotid/transcranial ultrasound testing in early prognosis of TIA patients]. , 2006, Medicina clinica.

[90]  K. Meyer-Wiethe,et al.  Acute stroke: perfusion imaging. , 2006, Frontiers of neurology and neuroscience.

[91]  M. Hennerici,et al.  Future developments in neurovascular ultrasound. , 2006, Frontiers of neurology and neuroscience.

[92]  U. Bogdahn,et al.  Sonographic parenchymal and brain perfusion imaging: preliminary results in four patients following decompressive surgery for malignant middle cerebral artery infarct. , 2001, Ultrasound in medicine & biology.

[93]  T. Elatrozy,et al.  Correlates of embolic events detected by means of transcranial Doppler in patients with carotid atheroma. , 2001, Journal of vascular surgery.

[94]  A. Alexandrov,et al.  Specific transcranial Doppler flow findings related to the presence and site of arterial occlusion. , 2000, Stroke.

[95]  G. Seidel,et al.  Harmonic imaging of the human brain. Visualization of brain perfusion with ultrasound. , 2000, Stroke.

[96]  C. Chin,et al.  Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[97]  R. Schlief,et al.  Acoustically stimulated microbubbles in diagnostic ultrasound: properties and implications for diagnostic use , 1997 .