Small-firm formation in biotechnology: A comparison of France, Britain and Canada

Abstract A comparison is made of the pattern of emergence, survival and growth of small biotechnology firms in France, Britain and Canada, using surveys in the three countries. These data are compared in turn with what is known about US biotechnology firms from the literature. Although the literature suggests that the appearance of new industries based on the emergence of new, small high-technology firms is a US phenomenon, evidence is presented of a nearly comparable pattern of small firm commercialisation of biotechnology in the three countries studied, relative to the size of the countries. However, the Canadian, French and British firms appeared 1–4 years later than the US firms, and are still somewhat weaker. While the US is generally held to have an entrepreneurial culture and a supportive private finance industry providing venture capital, which provide a stimulus to new high-technology firm formation, in the other three countries public policy — to a greater or lesser extent — made up for the relative lack of an entrepreneurial culture and private-sector finance. Differences in the financial institutions and instruments of public policy in all four countries are analysed. In each of them, networks of cooperation between other organisations, including established firms, also played an important role in the survival of the small biotechnology firms. Unlike the microelectronics experience, there was a complementary role for new and established, large and small firms, and the large established firms in end-user industries have not been pushed aside by the new dedicated biotechnology firms. Some of the new firms have grown and been successful; in some cases the complementary role has now been overtaken, and some of the small firms have been taken over by established ones.

[1]  Alice M. Sapienza,et al.  R&D collaboration as a global competitive tactic —Biotechnology and the ethical pharmaceutical industry , 1989 .

[2]  J. Hagedoorn,et al.  Inter-firm partnerships and co-operative strategies in core technologies , 1990 .

[3]  Roy Rothwell.  Venture finance, small firms and public policy in the UK , 1985 .

[4]  A. Scott,et al.  The Southern Californian medical device industry: Innovation, new firm formation, and location , 1992 .

[5]  Vivien Walsh,et al.  Technology and the economy -- the key relationships : (Organisation for economic co-operation and development, Paris, 1992) pp. 328, 260 FF , 1994 .

[6]  S. Winter,et al.  An evolutionary theory of economic change , 1983 .

[7]  Jacqueline Senker,et al.  Evaluating the funding of strategic science: Some lessons from British experience , 1991 .

[8]  K. Pavitt,et al.  Large Firms in the Production of the World's Technology: An Important Case of “Non-Globalisation” , 1991 .

[9]  Luigi Orsenigo,et al.  The emergence of biotechnology , 1989 .

[10]  D. Ball,et al.  Strategies of biotechnology companies , 1992 .

[11]  B. Lundvall.  National Systems of Innovation , 1992 .

[12]  Martin Kenney,et al.  Venture capital-financed innovation and technological change in the USA , 1988 .

[13]  John W. Wilson.  The New Venturers: Inside the High-Stakes World of Venture Capital , 1985 .

[14]  R. Nelson,et al.  National Innovation Systems , 1993 .

[15]  F. Dewhurst,et al.  Biotechnology and the Changing Role of Government , 1990 .

[16]  C. Freeman,et al.  New Explorations in the Economics of Technological Change , 1990 .

[17]  V. Walsh,et al.  New firms in the biotechnology industry : their contribution to innovation and growth , 1990 .

[18]  Erik Arnold,et al.  Parallel Convergence: National Strategies in Information Technology , 1986 .

[19]  R. Rothwell.  Small firms, innovation and industrial change , 1989 .

[20]  Christopher Freeman,et al.  Small Countries Facing the Technological Revolution , 1988 .

[21]  J. McCalman.  Management of innovation in high technology small firms , 1988 .

[22]  Keith Pavitt,et al.  Key Characteristics of the Large Innovating Firm , 1991 .

[23]  M. Sharp.  European Countries in Science-Based Competition: The Case of Biotechnology , 1991 .

[24]  Roger Déchanet,et al.  Rapport annuel d'activité , 1993 .

[25]  D. Teece.  Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy , 1993 .

[26]  J. Niosi.  New Technology Policy and Social Innovations in the Firm , 1994 .