Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing in Alzheimer’s Disease Cellular Models

[1]  F. Cicchetti,et al.  Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease , 2011, Journal of Lipid Research.

[2]  Artemis P. Simopoulos,et al.  Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain , 2011, Molecular Neurobiology.

[3]  F. Calon,et al.  Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models , 2011, PloS one.

[4]  G. Cole,et al.  Dietary fatty acids and the aging brain. , 2010, Nutrition reviews.

[5]  D. Mozaffarian,et al.  Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26–27 May 2010 , 2010, European Journal of Clinical Nutrition.

[6]  A. Obenaus,et al.  Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke , 2010, Translational Stroke Research.

[7]  R. Tanzi,et al.  The Genetics of Alzheimer Disease: Back to the Future , 2010, Neuron.

[8]  P. Tso,et al.  Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.

[9]  C. Haass.  Initiation and propagation of neurodegeneration , 2010, Nature Medicine.

[10]  Carl W. Cotman,et al.  Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease , 2010, PloS one.

[11]  E. Mandelkow,et al.  Fyn-Tau-Amyloid: A Toxic Triad , 2010, Cell.

[12]  Markus Tolnay,et al.  The propagation of prion-like protein inclusions in neurodegenerative diseases , 2010, Trends in Neurosciences.

[13]  N. Bazan,et al.  PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. , 2010, Experimental eye research.

[14]  N. Bazan,et al.  Neuroprotectin D1 Induces Dephosphorylation of Bcl-xL in a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival* , 2010, The Journal of Biological Chemistry.

[15]  William C. Gordon,et al.  Neuroprotectin D1 Attenuates Laser-induced Choroidal Neovascularization in Mouse , 2010, Molecular vision.

[16]  T. Montine,et al.  Biomarkers of oxidative damage and inflammation in Alzheimer's disease. , 2010, Biomarkers in medicine.

[17]  D. Baker,et al.  Inflammation in neurodegenerative diseases , 2010, Immunology.

[18]  D. Hoffman,et al.  Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials. , 2009, Prostaglandins, leukotrienes, and essential fatty acids.

[19]  J. Uddin,et al.  Selective Survival Rescue in 15-Lipoxygenase-1-deficient Retinal Pigment Epithelial Cells by the Novel Docosahexaenoic Acid-derived Mediator, Neuroprotectin D1* , 2009, The Journal of Biological Chemistry.

[20]  K. Yaffe,et al.  Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association , 2009, Nature Clinical Practice Neurology.

[21]  W. Banks,et al.  Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  T. Montine,et al.  Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid* , 2008, Journal of Biological Chemistry.

[23]  B. Teter,et al.  Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention , 2007, The Journal of Neuroscience.

[24]  N. Bazan.  Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. , 2007, Investigative ophthalmology & visual science.

[25]  W. Gordon,et al.  Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis , 2007, Proceedings of the National Academy of Sciences.

[26]  D. Bok,et al.  Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling , 2007, Proceedings of the National Academy of Sciences.

[27]  L. Lannfelt,et al.  Docosahexaenoic acid stimulates non‐amyloidogenic APP processing resulting in reduced Aβ levels in cellular models of Alzheimer's disease , 2007, The European journal of neuroscience.

[28]  J. Cui,et al.  Reduction of sortilin-1 in Alzheimer hippocampus and in cytokine-stressed human brain cells , 2007, Neuroreport.

[29]  Hong-Qi Yang,et al.  New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing α‐secretase activity , 2007, The European journal of neuroscience.

[30]  Charles N. Serhan,et al.  Resolvin E1 and protectin D1 activate inflammation-resolution programmes , 2007, Nature.

[31]  D. Selkoe,et al.  Aβ Oligomers – a decade of discovery , 2007, Journal of neurochemistry.

[32]  Frank M LaFerla,et al.  Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels , 2007, The Journal of Neuroscience.

[33]  D. Selkoe,et al.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.

[34]  D. Dickson,et al.  Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease , 2006 .

[35]  H. Tanila,et al.  Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice , 2006, Neurobiology of Disease.

[36]  T. Herdegen,et al.  The FASEB Journal • Research Communication Activation of cerebral peroxisome proliferator-activated , 2022 .

[37]  M. Sastre,et al.  Transcriptional and translational regulation of BACE1 expression—Implications for Alzheimer's disease , 2006, Progress in Neurobiology.

[38]  N. Bazan.  Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors , 2006, Trends in Neurosciences.

[39]  C. Serhan,et al.  Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. , 2006, The Journal of Immunology.

[40]  T. Klockgether,et al.  Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Rapoport,et al.  One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats Published, JLR Papers in Press, October 6, 2005. , 2006, Journal of Lipid Research.

[42]  N. Salem,et al.  An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n‐6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance , 2005, Journal of neurochemistry.

[43]  A. Pizzuti,et al.  Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. , 2005, The Biochemical journal.

[44]  Charles N Serhan,et al.  A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. , 2005, The Journal of clinical investigation.

[45]  N. Salem,et al.  N-3 Fatty Acid Deficiency Induced by a Modified Artificial Rearing Method Leads to Poorer Performance in Spatial Learning Tasks , 2005, Pediatric Research.

[46]  Zhiming Wen,et al.  Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Y. Surh,et al.  β-Amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase–NF-κB signaling pathway , 2005 .

[48]  Takashi Morihara,et al.  A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model , 2005, The Journal of Neuroscience.

[49]  T. Itoh,et al.  Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents. , 2005, Bioorganic & medicinal chemistry letters.

[50]  P. Mukherjee,et al.  Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Fessel,et al.  The biochemistry of the isoprostane, neuroprostane, and isofuran Pathways of lipid peroxidation. , 2004, Brain pathology.

[52]  Á. Simonyi,et al.  Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. , 2004, Journal of lipid research.

[53]  Song‐Pyo Hong,et al.  Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression* , 2003, Journal of Biological Chemistry.

[54]  M. Youdim,et al.  Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein* , 2002, The Journal of Biological Chemistry.

[55]  Hee-Yong Kim,et al.  Mechanisms of action of docosahexaenoic acid in the nervous system , 2001, Lipids.

[56]  F. Fahrenholz,et al.  Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases , 2001 .

[57]  G Durand,et al.  The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. , 1989, The Journal of nutrition.

[58]  D. Kögel,et al.  Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. , 2011, Biochimica et biophysica acta.

[59]  D. Dickson,et al.  Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. , 2006, Current Alzheimer research.

[60]  Y. Surh,et al.  Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway. , 2005, Free radical biology & medicine.

[61]  T. Klockgether,et al.  Nonsteroidal anti-inflammatory drugs repress (cid:1) -secretase gene promoter activity by the activation of PPAR (cid:2) , 2005 .

[62]  B. Henke.  1. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands and their therapeutic utility. , 2004, Progress in medicinal chemistry.

[63]  B. Henke.  Peroxisome proliferator-activated receptor gamma (PPARγ) ligands and their therapeutic utility , 2004 .

[64]  Nicolas G. Bazan,et al.  Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. , 2003, Journal of lipid research.

[65]  F. Fahrenholz,et al.  Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  A. Simopoulos.  Evolutionary Aspects of Diet , 2001 .

[67]  L. Horrocks,et al.  NMDA Receptor-Stimulated Release of Arachidonic Acid: Mechanisms for the Bazan Effect , 1994 .

[68]  Á. M. Municio.  Cell Signal Transduction, Second Messengers and Protein Phosphorylation in Health and Disease , 1994 .

[69]  Joe G. Hollyfield,et al.  Retinal degeneration : experimental and clinical studies , 1985 .