21 G-protein-coupled receptors and their regulation

[1]  J. Fargnoli,et al.  Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase , 1995, Molecular and cellular biology.

[2]  G. Cooper,et al.  Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells , 1995, Molecular and cellular biology.

[3]  J. Falck,et al.  Phosphatidylinositol(3, 4, 5) -Trisphosphate Stimulates Phosphorylation of Pleckstrin in Human Platelets (*) , 1995, The Journal of Biological Chemistry.

[4]  R. Lefkowitz,et al.  G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Y. Wan,et al.  Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[6]  P. Sigler,et al.  Scratching the surface with the PH domain , 1995, Nature Structural Biology.

[7]  R. Lefkowitz,et al.  Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway , 1995, Nature.

[8]  E. Peles,et al.  Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions , 1995, Nature.

[9]  G. Johnson,et al.  Mitogen-activated Protein Kinase Activation Requires Two Signal Inputs from the Human Anaphylatoxin C5a Receptor (*) , 1995, The Journal of Biological Chemistry.

[10]  G. Bokoch,et al.  G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes (*) , 1995, The Journal of Biological Chemistry.

[11]  S. Volinia,et al.  Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. , 1995, Science.

[12]  O. Hazeki,et al.  Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. , 1995, Trends in biochemical sciences.

[13]  H. Bourne,et al.  Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1. , 1995, Molecular biology of the cell.

[14]  R. Lefkowitz,et al.  Distinct Pathways of G- and G-mediated Mitogen-activated Protein Kinase Activation (*) , 1995, The Journal of Biological Chemistry.

[15]  N. Thanki,et al.  Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits. , 1995, Biochemistry.

[16]  R. Lefkowitz,et al.  Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase. , 1995, The Journal of Biological Chemistry.

[17]  Y. Kaziro,et al.  G protein βγ subunit activates Ras, Raf, and MAP kinase in HEK 293 cells , 1995 .

[18]  U. Banerjee,et al.  Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless (*) , 1995, The Journal of Biological Chemistry.

[19]  R. Lefkowitz,et al.  Effect of Cellular Expression of Pleckstrin Homology Domains on Gi-coupled Receptor Signaling(*) , 1995, The Journal of Biological Chemistry.

[20]  W. Moolenaar,et al.  Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger (*) , 1995, The Journal of Biological Chemistry.

[21]  F. Gaits,et al.  Tyrosine phosphorylation of an SH2‐containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin‐sensitive heterotrimeric G‐protein. , 1995, The EMBO journal.

[22]  C. Benjamin,et al.  Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells (*) , 1995, The Journal of Biological Chemistry.

[23]  T. Roberts,et al.  Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase(*) , 1995, The Journal of Biological Chemistry.

[24]  J. Blenis,et al.  The Pleckstrin Homology Domain in Insulin Receptor Substrate-1 Sensitizes Insulin Signaling (*) , 1995, The Journal of Biological Chemistry.

[25]  Julie A. Pitcher,et al.  Pleckstrin Homology Domain-mediated Membrane Association and Activation of the -Adrenergic Receptor Kinase Requires Coordinate Interaction with G Subunits and Lipid(*) , 1995, The Journal of Biological Chemistry.

[26]  J. Pouysségur,et al.  The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors (*) , 1995, The Journal of Biological Chemistry.

[27]  M. Šuša,et al.  Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells. , 1995, Oncogene.

[28]  H. Gavras,et al.  α2 Adrenergic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells Activate Differentially Mitogen-activated Protein Kinase by a p21ras Independent Pathway (*) , 1995, The Journal of Biological Chemistry.

[29]  D. Bowtell,et al.  A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways , 1995, Molecular and cellular biology.

[30]  R. Lefkowitz,et al.  Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Simon,et al.  Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. Pouysségur,et al.  Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts. , 1994, The Journal of biological chemistry.

[33]  A. Strosberg,et al.  Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes. , 1994, The Journal of biological chemistry.

[34]  P. Hajduk,et al.  Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate , 1994, Nature.

[35]  P. Crespo,et al.  Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. , 1994, The Journal of biological chemistry.

[36]  D. Baltimore,et al.  Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[37]  G. Johnson,et al.  FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. , 1994, The Journal of clinical investigation.

[38]  P. Casey,et al.  A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. , 1994, The Journal of biological chemistry.

[39]  R. Lefkowitz,et al.  Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Hawkins,et al.  A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits , 1994, Cell.

[41]  R. Lefkowitz,et al.  Binding of G protein beta gamma-subunits to pleckstrin homology domains. , 1994, The Journal of biological chemistry.

[42]  H. Bourne,et al.  cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. , 1994, The Journal of biological chemistry.

[43]  R. Lefkowitz,et al.  Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. , 1994, The Journal of biological chemistry.

[44]  A. Saltiel,et al.  Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. , 1994, The Journal of biological chemistry.

[45]  P. Hordijk,et al.  cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts. , 1994, The Journal of biological chemistry.

[46]  N. Qian,et al.  Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation. , 1994, The Journal of biological chemistry.

[47]  P. Hordijk,et al.  Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. , 1994, The Journal of biological chemistry.

[48]  C. Crews,et al.  Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[49]  S. Cook,et al.  Inhibition by cAMP of Ras-dependent activation of Raf. , 1993, Science.

[50]  R. Weinberg,et al.  The pathway to signal achievement , 1993, Nature.

[51]  G. Milligan,et al.  Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. , 1993, The Journal of biological chemistry.

[52]  C. Marshall,et al.  Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1. , 1993, The Journal of biological chemistry.

[53]  David E. Clapham,et al.  New roles for G-protein (βγ-dimers in transmembrane signalling , 1993, Nature.

[54]  A. Harootunian,et al.  A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells. , 1993, The Journal of biological chemistry.

[55]  N. Qian,et al.  Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. , 1993, The Journal of biological chemistry.

[56]  G. Johnson,et al.  Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins. , 1993, The Journal of biological chemistry.

[57]  Walter Kolch,et al.  Protein kinase Cα activates RAF-1 by direct phosphorylation , 1993, Nature.

[58]  J. Blenis,et al.  Signal transduction via the MAP kinases: proceed at your own RSK. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Weber,et al.  Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. , 1993, Science.

[60]  T. Pawson,et al.  The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 , 1993, Nature.

[61]  W. Herman,et al.  Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src. , 1993, The Journal of biological chemistry.

[62]  R. Lefkowitz,et al.  The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. , 1993, The Journal of biological chemistry.

[63]  C. Molloy,et al.  Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells. , 1993, The Journal of biological chemistry.

[64]  R. Medema,et al.  Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[65]  John Kuriyan,et al.  Structures of SH2 and SH3 domains , 1993 .

[66]  A. Saltiel,et al.  Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells. , 1993, The Biochemical journal.

[67]  E. Van Obberghen,et al.  Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. , 1993, The Biochemical journal.

[68]  R. Medema,et al.  The role of p21ras in receptor tyrosine kinase signaling. , 1993, Critical reviews in oncogenesis.

[69]  M. Nakafuku,et al.  Function of Ras as a molecular switch in signal transduction. , 1992, The Journal of biological chemistry.

[70]  E. Krebs,et al.  The mitogen-activated protein kinase activator. , 1992, Current opinion in cell biology.

[71]  T. Pawson,et al.  SH2 and SH3 domains: From structure to function , 1992, Cell.

[72]  S. Grinstein,et al.  Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils. , 1992, Journal of Biological Chemistry.

[73]  J. B. Higgins,et al.  Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. , 1992, Science.

[74]  A. Ullrich,et al.  The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling , 1992, Cell.

[75]  O. Hazeki,et al.  Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation. , 1992, The Biochemical journal.

[76]  David L. Brautigan,et al.  Raf-1 activates MAP kinase-kinase , 1992, Nature.

[77]  K. Jalink,et al.  Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid. , 1992, The EMBO journal.

[78]  L. Heasley,et al.  MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. , 1992, The Journal of biological chemistry.

[79]  V. Wheaton,et al.  Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation , 1991, Cell.

[80]  M. Caron,et al.  Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. , 1990, Cell regulation.

[81]  Kees Jalink,et al.  Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins , 1989, Cell.

[82]  G. Cooper,et al.  Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP , 1988, Molecular and cellular biology.

[83]  L. B. Chen,et al.  Mitogenic activity of blood components. I. Thrombin and prothrombin. , 1975, Proceedings of the National Academy of Sciences of the United States of America.