The MATRICS Consensus Cognitive Battery (MCCB): Clinical and cognitive correlates

The purpose of this study was to examine the cognitive and clinical correlates of the MATRICS Consensus Cognitive Battery (MCCB) which was originally developed to be an endpoint for cognitive enhancement clinical trials. In a sample of 117 people with schizophrenia and 77 healthy control participants we found the following: a) the MCCB was highly sensitive to the type and level of impairment typically observed in schizophrenia, b) the MCCB composite score was highly correlated with WASI Estimated Full Scale IQ score, c) that the MCCB domain scores were generally moderately-highly intercorrelated, d) that MCCB performance was minimally related to clinical symptom type and severity, and e) the MCCB is sensitive to employment status with better performance in employed vs. unemployed patients. These data support the validity of the MCCB as a sensitive measure of cognitive impairment in schizophrenia and suggest that MCCB performance is relevant for functional outcome. The data also suggest that the MCCB domain scores may offer limited resolution on discrete cognitive functions.

[1]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[2]  Jean Addington,et al.  Reliability and validity of a depression rating scale for schizophrenics , 1991, Schizophrenia Research.

[3]  R. Heinrichs,et al.  Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. , 1998, Neuropsychology.

[4]  Michael F. Green,et al.  The MCCB impairment profile for schizophrenia outpatients: Results from the MATRICS psychometric and standardization study , 2011, Schizophrenia Research.

[5]  Michael F. Green,et al.  The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. , 2008, The American journal of psychiatry.

[6]  P. DeRosse,et al.  Cognitive and symptomatic predictors of functional disability in schizophrenia , 2011, Schizophrenia Research.

[7]  John O. Willis,et al.  Wechsler Abbreviated Scale of Intelligence , 2014 .

[8]  Niels G. Waller.  The Scale for the Assessment of Negative Symptoms , 1995 .

[9]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[10]  C. Carter,et al.  Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative. , 2007, Schizophrenia bulletin.

[11]  M. First,et al.  Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet , 1997 .

[12]  Philip D. Harvey,et al.  Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial , 2011, Schizophrenia Research.

[13]  T. Q. Irigaray,et al.  Intellectual abilities in Alzheimer's disease patients: Contributions from the Wechsler Abbreviated Scale of Intelligence (WASI) , 2010 .

[14]  J. Strauss,et al.  Diagnostic criteria and five-year outcome in schizophrenia. A report from the International Pilot Study of schizophrenia. , 1975, Archives of general psychiatry.

[15]  Brown Ea.  Overlooking the obvious. , 1969 .

[16]  N. Kapur.  Neuropsychological Assessment, Fourth Edition , 2005, Journal of Neurology.

[17]  J. Gold,et al.  Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. , 2007, Archives of general psychiatry.

[18]  Michael F. Green,et al.  The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization. , 2008, The American journal of psychiatry.