Continuous Sample Preparation Using Free-flow electrophoresis On A Silicon Microstructure

A miniaturized version of a continuous-flow electrophoretic device is presented. The small internal volumes make this technique attractive for biochemists. Separations of small ions, peptides and whole cells are given.

[1]  D. J. Harrison,et al.  Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip , 1993, Science.

[2]  Andreas Manz,et al.  High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device , 1994 .

[3]  Analytical SPLITT fractionation in the diffusion mode operating as a dialysis-like system devoid of membrane. Application to drug-carrying liposomes , 1993 .

[4]  A. Manz,et al.  µ-TAS: Miniaturized Total Chemical Analysis Systems , 1995 .

[5]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .

[6]  Andreas Manz,et al.  Continuous Sample Pretreatment Using a Free-Flow Electrophoresis Device Integrated onto a Silicon Chip , 1994 .

[7]  S. Terry.  A gas chromatography system fabricated on a silicon wafer using integrated circuit technology , 1975 .

[8]  A. Manz,et al.  Synchronized Cyclic Capillary Electrophoresis - A Novel Approach to Ion Separations in Solution , 1993 .

[9]  S. Jeanneret,et al.  Three-dimensional micro flow manifolds for miniaturized chemical analysis systems , 1994 .

[10]  H. Wagner,et al.  Free-flow electrophoresis , 1989, Nature.

[11]  A. Manz,et al.  A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE) , 1994 .

[12]  A. Ewing,et al.  Continuous electrophoretic separations in narrow channels coupled to small-bore capillaries. , 1993, Analytical chemistry.