Translation of infrared chemical imaging for cardiovascular evaluation

Infrared (IR) spectroscopic imaging has been applied to study histology of cardiovascular tissue, primarily using Fourier transform IR (FTIR) Imaging. Here we describe results for histologic imaging of cardiac biopsies using a fast, discrete frequency IR (DFIR) imaging system. Histologic classification of tissue is understood in terms of the constituent frequencies and speeded up by careful optimization of the data acquired. Results are compared to FTIR imaging in terms of the signal to noise ratio and information content.

[1]  R. Bhargava,et al.  On the importance of image formation optics in the design of infrared spectroscopic imaging systems. , 2014, The Analyst.

[2]  S. Kazarian,et al.  Spectroscopic imaging of arteries and atherosclerotic plaques. , 2004, Biopolymers.

[3]  Paolo Ferraris,et al.  FT-IR microimaging spectroscopy: A comparison between healthy and neoplastic human colon tissues , 2008 .

[4]  Saurabh Sinha,et al.  Analysis of variance in spectroscopic imaging data from human tissues. , 2012, Analytical chemistry.

[5]  K. Malek,et al.  Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. , 2011, The Analyst.

[6]  Histopathology mapping of biochemical changes in myocardial infarction by Fourier transform infrared spectral imaging. , 2011, Forensic science international.

[7]  R. Bhargava,et al.  Computational Chemical Imaging for Cardiovascular Pathology: Chemical Microscopic Imaging Accurately Determines Cardiac Transplant Rejection , 2015, PloS one.

[8]  Rohit Bhargava,et al.  High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data. , 2006, Biochimica et biophysica acta.

[9]  H. Mantsch,et al.  Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy. , 1996, Biochimica et biophysica acta.

[10]  Y Wang,et al.  Multi-Wavelength Mid-Infrared Micro-Spectral Imaging Using Semiconductor Lasers , 2003, Applied spectroscopy.

[11]  Paul Bassan,et al.  Large scale infrared imaging of tissue micro arrays (TMAs) using a tunable Quantum Cascade Laser (QCL) based microscope. , 2014, The Analyst.

[12]  Matthew J Baker,et al.  Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm. , 2016, The Analyst.

[13]  Rohit Bhargava,et al.  Towards a practical Fourier transform infrared chemical imaging protocol for cancer histopathology , 2007, Analytical and bioanalytical chemistry.

[14]  K Z Liu,et al.  Distribution of collagen deposition in cardiomyopathic hamster hearts determined by infrared microscopy. , 1999, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[15]  Thomas Brüning,et al.  Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging. , 2015, The Analyst.

[16]  Vishal K. Varma,et al.  High-definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology , 2015, Journal of visualized experiments : JoVE.

[17]  Rohit Bhargava,et al.  Integration of Molecular Profiling and Chemical Imaging to Elucidate Fibroblast-Microenvironment Impact on Cancer Cell Phenotype and Endocrine Resistance in Breast Cancer , 2014, PloS one.

[18]  M. Phillips,et al.  Infrared hyperspectral imaging using a broadly tunable external cavity quantum cascade laser and microbolometer focal plane array. , 2008, Optics express.

[19]  S. Hewitt,et al.  Infrared spectroscopic imaging for histopathologic recognition , 2005, Nature Biotechnology.

[20]  P. Torzilli,et al.  Fourier Transform Infrared Spectral Analysis of Degenerative Cartilage: An Infrared Fiber Optic Probe and Imaging Study , 2004, Applied spectroscopy.

[21]  David Mayerich,et al.  Real-time interactive data mining for chemical imaging information: application to automated histopathology , 2013, BMC Bioinformatics.

[22]  Wolfgang Petrich,et al.  Quantum cascade laser–based hyperspectral imaging of biological tissue , 2014, Journal of biomedical optics.

[23]  Rohit Bhargava,et al.  Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging. , 2016, Faraday discussions.

[24]  Collagen remodeling in the extracellular matrix of the cardiomyopathic Syrian hamster heart as assessed by FTIR attenuated total reflectance spectroscopy , 1999 .

[25]  Rohit Bhargava,et al.  High-Definition Infrared Spectroscopic Imaging , 2013, Applied spectroscopy.

[26]  Rohit Bhargava,et al.  Extracting Knowledge from Chemical Imaging Data Using Computational Algorithms for Digital Cancer Diagnosis , 2015, The Yale journal of biology and medicine.

[27]  Erik Goormaghtigh,et al.  Infrared imaging of MDA-MB-231 breast cancer cell line phenotypes in 2D and 3D cultures. , 2015, The Analyst.

[28]  Rohit Bhargava,et al.  Fourier transform infrared (FT-IR) spectroscopy and imaging of the nucleus to characterize DNA contributions in different phases of the cell cycle , 2015, Medical Imaging.

[29]  Rohit Bhargava,et al.  Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade laser. , 2012, Analytical chemistry.

[30]  D. Bertrand,et al.  Detection of pathological aortic tissues by infrared multispectral imaging and chemometrics. , 2008, The Analyst.

[31]  Rohit Bhargava,et al.  Fast Infrared Chemical Imaging with a Quantum Cascade Laser , 2014, Analytical chemistry.

[32]  N. Pleshko,et al.  Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction. , 2012, Journal of biomedical optics.

[33]  Virgilia Macias,et al.  High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams , 2011, Nature Methods.

[34]  David Mayerich,et al.  High Definition Infrared Spectroscopic Imaging for Lymph Node Histopathology , 2015, PloS one.

[35]  I. Dixon,et al.  Fourier transform infrared evaluation of microscopic scarring in the cardiomyopathic heart: effect of chronic AT1 suppression. , 2003, Analytical biochemistry.

[36]  Michael J. Walsh,et al.  High-resolution mid-infrared imaging for disease diagnosis , 2012, Other Conferences.

[37]  W Petrich,et al.  Rapid identification of goblet cells in unstained colon thin sections by means of quantum cascade laser-based infrared microspectroscopy. , 2015, The Analyst.

[38]  David Mayerich,et al.  Recovery of Absorption Spectra from Fourier Transform Infrared (FT-IR) Microspectroscopic Measurements of Intact Spheres , 2013, Applied spectroscopy.

[39]  R. Bhargava,et al.  Improving Prediction of Prostate Cancer Recurrence using Chemical Imaging , 2015, Scientific Reports.

[40]  David Mayerich,et al.  Stain-less staining for computed histopathology. , 2015, Technology.

[41]  S. Kazarian,et al.  Micro ATR-FTIR spectroscopic imaging of atherosclerosis: an investigation of the contribution of inducible nitric oxide synthase to lesion composition in ApoE-null mice. , 2009, The Analyst.

[42]  M. Kon,et al.  Infrared spectral histopathology (SHP): a novel diagnostic tool for the accurate classification of lung cancer , 2012, Laboratory Investigation.

[43]  Wolfgang Petrich,et al.  Real‐time mid‐infrared imaging of living microorganisms , 2016, Journal of biophotonics.

[44]  Antonella I. Mazur,et al.  Molecular pathology via IR and Raman spectral imaging , 2013, Journal of biophotonics.

[45]  P. Lasch,et al.  Early alterations in myocardia and vessels of the diabetic rat heart: an FTIR microspectroscopic study. , 2006, The Biochemical journal.

[46]  Nicholas Stone,et al.  High-resolution FTIR imaging of colon tissues for elucidation of individual cellular and histopathological features. , 2016, The Analyst.