Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.

[1]  C. Glass,et al.  The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.

[2]  M. Garber,et al.  HIV-1 Tat: coping with negative elongation factors. , 1999, Current opinion in immunology.

[3]  M. Lazar,et al.  Modulating nuclear receptor function: may the phos be with you. , 1999, The Journal of clinical investigation.

[4]  J. Greenblatt,et al.  GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8. , 1999, Molecular cell.

[5]  Paul Tempst,et al.  Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex , 1999, Nature.

[6]  L. Freedman Increasing the Complexity of Coactivation in Nuclear Receptor Signaling , 1999, Cell.

[7]  W. de Laat,et al.  Molecular mechanism of nucleotide excision repair. , 1999, Genes & development.

[8]  J. Qin,et al.  Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. , 1999, Molecular cell.

[9]  Simak Ali,et al.  Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization , 1999, Molecular and Cellular Biology.

[10]  F. Tirode,et al.  Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. , 1999, Molecular cell.

[11]  David A. Agard,et al.  The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen , 1998, Cell.

[12]  V. Ogryzko,et al.  Regulation of activity of the transcription factor GATA-1 by acetylation , 1998, Nature.

[13]  M. Montenarh,et al.  Regulation of CAK kinase activity by p53 , 1998, Oncogene.

[14]  R. Young,et al.  Regulatory targets in the RNA polymerase II holoenzyme. , 1998, Current opinion in genetics & development.

[15]  H. Gronemeyer,et al.  The nuclear receptor ligand-binding domain: structure and function. , 1998, Current opinion in cell biology.

[16]  D. Lannigan,et al.  Estradiol-induced Phosphorylation of Serine 118 in the Estrogen Receptor Is Independent of p42/p44 Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.

[17]  J. T. Kadonaga,et al.  p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. , 1998, Genes & development.

[18]  G. Orphanides,et al.  The RNA polymerase II general transcription factors: past, present, and future. , 1998, Cold Spring Harbor symposia on quantitative biology.

[19]  E. Kalkhoven,et al.  Isoforms of steroid receptor co‐activator 1 differ in their ability to potentiate transcription by the oestrogen receptor , 1998, The EMBO journal.

[20]  X. Chen,et al.  p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner , 1997, Molecular and cellular biology.

[21]  N. Segil,et al.  The Cyclin-dependent Kinase-activating Kinase (CAK) Assembly Factor, MAT1, Targets and Enhances CAK Activity on the POU Domains of Octamer Transcription Factors* , 1997, The Journal of Biological Chemistry.

[22]  Zbigniew Dauter,et al.  Molecular basis of agonism and antagonism in the oestrogen receptor , 1997, Nature.

[23]  Simak Ali,et al.  Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α* , 1997, The Journal of Biological Chemistry.

[24]  Wei Gu,et al.  Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain , 1997, Cell.

[25]  P. Chambon,et al.  Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7 , 1997, Cell.

[26]  J. Egly,et al.  Substrate specificity of the cdk‐activating kinase (CAK) is altered upon association with TFIIH , 1997, The EMBO journal.

[27]  D. Bentley,et al.  Regulation of CDK7 substrate specificity by MAT1 and TFIIH , 1997, The EMBO journal.

[28]  E. Kalkhoven,et al.  Ligand‐independent activation of the oestrogen receptor by mutation of a conserved tyrosine , 1997, The EMBO journal.

[29]  D O Morgan,et al.  Cyclin-dependent kinases: engines, clocks, and microprocessors. , 1997, Annual review of cell and developmental biology.

[30]  E. Nigg Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? , 1996, Current opinion in cell biology.

[31]  T. Léveillard,et al.  Functional interactions between p53 and the TFIIH complex are affected by tumour‐associated mutations. , 1996, The EMBO journal.

[32]  E. Nigg,et al.  MAT1, cdk7 and cyclin H form a kinase complex which is UV light‐sensitive upon association with TFIIH. , 1996, The EMBO journal.

[33]  R. Roeder Nuclear RNA polymerases: role of general initiation factors and cofactors in eukaryotic transcription. , 1996, Methods in enzymology.

[34]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[35]  Daniel Metzger,et al.  Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.

[36]  E. Nigg,et al.  In vitro assembly of a functional human CDK7‐cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. , 1995, The EMBO journal.

[37]  P. Kushner,et al.  Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. , 1995, The EMBO journal.

[38]  D. Reinberg,et al.  Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53 , 1994, Molecular and cellular biology.

[39]  S. F. Arnold,et al.  Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. , 1994, Molecular endocrinology.

[40]  B. Katzenellenbogen,et al.  Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. , 1994, The Journal of biological chemistry.

[41]  B. O’Malley,et al.  Molecular mechanisms of action of steroid/thyroid receptor superfamily members. , 1994, Annual review of biochemistry.

[42]  D. Metzger,et al.  Production and characterization of monoclonal antibodies recognising defined regions of the human oestrogen receptor. , 1993, Hybridoma.

[43]  P. Chambon,et al.  Modulation of transcriptional activation by ligand‐dependent phosphorylation of the human oestrogen receptor A/B region. , 1993, The EMBO journal.

[44]  J. Lees,et al.  Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. , 1992, The EMBO journal.

[45]  P. Chambon,et al.  Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2. , 1991, The Journal of biological chemistry.

[46]  H. Gronemeyer,et al.  Transcription activation by estrogen and progesterone receptors. , 1991, Annual review of genetics.