Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk

[1]  D. Clayton.  Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes , 2009, PLoS genetics.

[2]  E. Fombonne.  Epidemiology of Pervasive Developmental Disorders , 2009, Pediatric Research.

[3]  Robert T. Schultz,et al.  Common genetic variants on 5p14.1 associate with autism spectrum disorders , 2009, Nature.

[4]  A. Philippi,et al.  Robust physical methods that enrich genomic regions identical by descent for linkage studies: confirmation of a locus for osteogenesis imperfecta , 2009 .

[5]  F. Vaglini,et al.  Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice , 2009, Neuroscience.

[6]  A. Janssens,et al.  Genome-based prediction of common diseases: methodological considerations for future research , 2009, Genome Medicine.

[7]  L. T. Middleton,et al.  Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score—the CoLaus Study , 2009, Diabetologia.

[8]  R. D'Agostino,et al.  Genotype score in addition to common risk factors for prediction of type 2 diabetes. , 2008, The New England journal of medicine.

[9]  Mark I. McCarthy,et al.  Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk , 2008, Diabetes.

[10]  A. Cecile J.W. Janssens,et al.  Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies , 2008, Diabetes.

[11]  S. Yusuf,et al.  Polygenic determinants of severe hypertriglyceridemia. , 2008, Human molecular genetics.

[12]  U. Rout,et al.  A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies. , 2008, Medical hypotheses.

[13]  Margaret S Pepe,et al.  Gauging the performance of SNPs, biomarkers, and clinical factors for predicting risk of breast cancer. , 2008, Journal of the National Cancer Institute.

[14]  M. Gail.  Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk. , 2008, Journal of the National Cancer Institute.

[15]  M. Permutt,et al.  Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value , 2008, PloS one.

[16]  D. Geschwind,et al.  Advances in autism genetics: on the threshold of a new neurobiology , 2008, Nature Reviews Genetics.

[17]  Pinchen Yang,et al.  Association of the Homeobox Transcription Factor Gene ENGRAILED 2 with Autistic Disorder in Chinese Children , 2008, Neuropsychobiology.

[18]  Eric Hollander,et al.  Autism‐related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[19]  J. Buxbaum,et al.  SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects , 2008, Molecular Psychiatry.

[20]  Olle Melander,et al.  Polymorphisms associated with cholesterol and risk of cardiovascular events. , 2008, The New England journal of medicine.

[21]  Qing Lu,et al.  Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. , 2008, American journal of human genetics.

[22]  Pär Stattin,et al.  Cumulative association of five genetic variants with prostate cancer. , 2008, The New England journal of medicine.

[23]  Joshua M. Korn,et al.  Association between microdeletion and microduplication at 16p11.2 and autism. , 2008, The New England journal of medicine.

[24]  E. Trabetti,et al.  Combined Effect of Hemostatic Gene Polymorphisms and the Risk of Myocardial Infarction in Patients with Advanced Coronary Atherosclerosis , 2008, PloS one.

[25]  A. Philippi,et al.  Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis , 2007, BMC Medical Genetics.

[26]  C. Johnson,et al.  Identification and Evaluation of Children With Autism Spectrum Disorders , 2007, Pediatrics.

[27]  J. Pankow,et al.  Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. , 2007, American journal of epidemiology.

[28]  Kenny Q. Ye,et al.  Strong Association of De Novo Copy Number Mutations with Autism , 2007, Science.

[29]  G. Dawson,et al.  Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale , 2007, Journal of autism and developmental disorders.

[30]  Thomas Bourgeron,et al.  Mapping autism risk loci using genetic linkage and chromosomal rearrangements , 2007, Nature Genetics.

[31]  G. Dawson,et al.  Evidence for multiple loci from a genome scan of autism kindreds , 2006, Molecular Psychiatry.

[32]  Mark Walker,et al.  Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction , 2006, PLoS medicine.

[33]  Ewout W Steyerberg,et al.  Predictive testing for complex diseases using multiple genes: Fact or fiction? , 2006, Genetics in Medicine.

[34]  C. Lajonchere,et al.  Autistic social impairment in the siblings of children with pervasive developmental disorders. , 2006, The American journal of psychiatry.

[35]  M. Gill,et al.  Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. , 2005, The American journal of psychiatry.

[36]  L. Groop,et al.  Genetic Prediction of Future Type 2 Diabetes , 2005, PLoS medicine.

[37]  Emanuel Dicicco-Bloom,et al.  Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. , 2005, American journal of human genetics.

[38]  M. Lauritsen,et al.  Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. , 2005, Journal of child psychology and psychiatry, and allied disciplines.

[39]  Chun Li,et al.  Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates , 2005, BMC Medical Genetics.

[40]  E. Cook,et al.  Molecular genetics of autism spectrum disorder , 2004, Molecular Psychiatry.

[41]  R. Benayed,et al.  Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder , 2004, Molecular Psychiatry.

[42]  Heather J Cordell,et al.  Properties of case/pseudocontrol analysis for genetic association studies: Effects of recombination, ascertainment, and multiple affected offspring , 2004, Genetic epidemiology.

[43]  Heather J Cordell,et al.  Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene‐gene and gene‐environment interactions, and parent‐of‐origin effects , 2004, Genetic epidemiology.

[44]  K. Davis,et al.  Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. , 2004, The American journal of psychiatry.

[45]  Philippa J Talmud,et al.  Genetic Testing for Cardiovascular Disease Susceptibility: A Useful Clinical Management Tool or Possible Misinformation? , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[46]  Thomas Bourgeron,et al.  Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism , 2003, Nature Genetics.

[47]  T. Fojo,et al.  Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase. , 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[48]  Muin J Khoury,et al.  Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. , 2003, American journal of human genetics.

[49]  A. Chicz–DeMet,et al.  Disregulation of proopiomelanocortin and contagious maladaptive behavior , 2002, Regulatory Peptides.

[50]  Douglas F. Easton,et al.  Polygenic susceptibility to breast cancer and implications for prevention , 2002, Nature Genetics.

[51]  J. Gilbert,et al.  Genomic screen and follow-up analysis for autistic disorder. , 2002, American journal of medical genetics.

[52]  M. Lauritsen,et al.  The genetics of autism , 2001, Acta psychiatrica Scandinavica.

[53]  B. Leventhal,et al.  The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism , 2000, Journal of autism and developmental disorders.

[54]  S. Rogers.  Empirically supported comprehensive treatments for young children with autism. , 1998, Journal of clinical child psychology.

[55]  S. Johnson,et al.  Empirically supported psychosocial interventions for children: an overview. , 1998, Journal of clinical child psychology.

[56]  P. Bolton,et al.  Autism, affective and other psychiatric disorders: patterns of familial aggregation , 1998, Psychological Medicine.

[57]  A. Couteur,et al.  Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders , 1994, Journal of autism and developmental disorders.

[58]  B J Freeman,et al.  Complex segregation analysis of autism. , 1991, American journal of human genetics.

[59]  S. Antonarakis,et al.  Vogel and Motulsky's Human Genetics: Problems and Approaches , 1986 .

[60]  E. DeLong,et al.  Sensitivity and specificity of a monitoring test. , 1985, Biometrics.

[61]  K. Narayan,et al.  Clinical risk factors, DNA variants, and the development of type 2 diabetes. , 2009, The New England journal of medicine.

[62]  S. Humphries,et al.  Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. , 2007, Clinical chemistry.

[63]  Thomas Bourgeron,et al.  Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders , 2007, Nature Genetics.

[64]  J. Terzic,et al.  Slower cortisol response during ACTH stimulation test in autistic children , 2007, European Child & Adolescent Psychiatry.

[65]  O. Mors,et al.  A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands , 2006, Molecular Psychiatry.

[66]  J. Terzic,et al.  Lower Cortisol and Higher ACTH Levels in Individuals with Autism , 2003, Journal of autism and developmental disorders.

[67]  J. Chang-Claude,et al.  Identifying influential families using regression diagnostics for generalized estimating equations , 1998, Genetic epidemiology.

[68]  P. J. Krantz,et al.  Age at intervention and treatment outcome for autistic children in a comprehensive intervention program , 1985 .