TPX2: of spindle assembly, DNA damage response, and cancer
暂无分享,去创建一个
[1] T. Chou,et al. TPX2 expression is associated with cell proliferation and patient outcome in esophageal squamous cell carcinoma , 2014, Journal of Gastroenterology.
[2] Hongchun Liu,et al. Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma. , 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[3] P. Binarová,et al. Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells , 2013, Journal of experimental botany.
[4] Changbao Xu,et al. Target protein for Xklp2 (TPX2), a microtubule-related protein, contributes to malignant phenotype in bladder carcinoma , 2013, Tumor Biology.
[5] Ju-Seog Lee,et al. Glioma pathogenesis‐related protein 1 induces prostate cancer cell death through Hsc70‐mediated suppression of AURKA and TPX2 , 2013, Molecular oncology.
[6] Chi-Ying F. Huang,et al. Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules , 2013, Proceedings of the National Academy of Sciences.
[7] T. Mitchison,et al. Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2 , 2013, Cell.
[8] E. Chatzaki,et al. γ-H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer , 2012, OncoTargets and therapy.
[9] H. van Attikum,et al. Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) Regulates γ-Histone 2AX (γ-H2AX) Levels upon Ionizing Radiation* , 2012, The Journal of Biological Chemistry.
[10] Jyoti Iyer,et al. A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex. , 2012, Cellular signalling.
[11] O. Kallioniemi,et al. High-Throughput Transcriptomic and RNAi Analysis Identifies AIM1, ERGIC1, TMED3 and TPX2 as Potential Drug Targets in Prostate Cancer , 2012, PloS one.
[12] Sven Diederichs,et al. The hallmarks of cancer , 2012, RNA biology.
[13] Jingzhi Wang,et al. The TPX2 gene is a promising diagnostic and therapeutic target for cervical cancer. , 2012, Oncology reports.
[14] Dafydd G. Thomas,et al. A Small-Molecule Inhibitor Targeting the Mitotic Spindle Checkpoint Impairs the Growth of Uterine Leiomyosarcoma , 2012, Clinical Cancer Research.
[15] M. Malumbres,et al. Tpx2 controls spindle integrity, genome stability, and tumor development. , 2012, Cancer research.
[16] V. Bisaria,et al. Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence. , 2012, The international journal of biochemistry & cell biology.
[17] P. Binarová,et al. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication. , 2012, The New phytologist.
[18] Michael C. Rusch,et al. Integrated cross-species transcriptional network analysis of metastatic susceptibility , 2012, Proceedings of the National Academy of Sciences.
[19] V. Bisaria,et al. Ashwagandha Derived Withanone Targets TPX2-Aurora A Complex: Computational and Experimental Evidence to its Anticancer Activity , 2012, PloS one.
[20] Mark A van de Wiel,et al. TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression , 2011, Gut.
[21] Bin Zhang,et al. PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse , 2011, Nucleic Acids Res..
[22] G. Goshima,et al. Identification of a TPX2-Like Microtubule-Associated Protein in Drosophila , 2011, PloS one.
[23] Marc Vidal,et al. Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer , 2011, PLoS biology.
[24] P. Wadsworth,et al. TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle , 2011, The Journal of cell biology.
[25] M. Timmermans,et al. Constitutive expression of γ-H2AX has prognostic relevance in triple negative breast cancer. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[26] F. Gage,et al. BRCA1 tumor suppression occurs via heterochromatin mediated silencing , 2011, Nature.
[27] Shipra Agrawal,et al. Biology of Aurora A kinase: Implications in cancer manifestation and therapy , 2011, Medicinal research reviews.
[28] Devin K Schweppe,et al. Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells , 2011, Science Signaling.
[29] S. Jackson,et al. Give me a break, but not in mitosis , 2011, Cell cycle.
[30] G. Heinze,et al. Expression of γ-H2AX in endometrial carcinomas: an immunohistochemical study with p53. , 2011, Gynecologic oncology.
[31] A. Kimura,et al. Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain , 2011, The EMBO journal.
[32] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[33] W. Huttner,et al. Cortical progenitor expansion, self-renewal and neurogenesis—a polarized perspective , 2011, Current Opinion in Neurobiology.
[34] P. Lavia,et al. Control of Aurora-A stability through interaction with TPX2 , 2011, Journal of Cell Science.
[35] Arie Perry,et al. Identification of Gene Markers Associated With Aggressive Meningioma by Filtering Across Multiple Sets of Gene Expression Arrays , 2011, Journal of neuropathology and experimental neurology.
[36] Giulia Guarguaglini,et al. The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme? , 2010, Biochimica et biophysica acta.
[37] Roland A. Pache,et al. Uncovering new substrates for Aurora A kinase , 2010, EMBO reports.
[38] D. Livingston,et al. Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation , 2010, Proceedings of the National Academy of Sciences.
[39] Kylie L. Gorringe,et al. Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian Cancer , 2010, PloS one.
[40] Yan Yan,et al. Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly , 2010, Science China Life Sciences.
[41] Navjot Shah,et al. Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling , 2010, PloS one.
[42] X. Qi,et al. Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma , 2010, Brain Research.
[43] S. Jackson,et al. DNA damage signaling in response to double-strand breaks during mitosis , 2010, The Journal of cell biology.
[44] D. Bartsch,et al. Quantitative analysis of conditional gene inactivation using rationally designed, tetracycline-controlled miRNAs , 2010, Nucleic acids research.
[45] H. Katayama,et al. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A , 2010, The Journal of cell biology.
[46] Xinbin Chen,et al. Examination of the expanding pathways for the regulation of p21 expression and activity. , 2010, Cellular signalling.
[47] S. Hirohashi,et al. Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma , 2010, Clinical Cancer Research.
[48] Terence P. Speed,et al. Identification of Candidate Growth Promoting Genes in Ovarian Cancer through Integrated Copy Number and Expression Analysis , 2010, PloS one.
[49] D. Compton,et al. Mechanisms of Chromosomal Instability , 2010, Current Biology.
[50] M. Stewart,et al. Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin-α* , 2010, The Journal of Biological Chemistry.
[51] C. Fagerstrom,et al. Poleward Transport of TPX2 in the Mammalian Mitotic Spindle Requires Dynein, Eg5, and Microtubule Flux , 2010, Molecular biology of the cell.
[52] T. Halazonetis,et al. Genomic instability — an evolving hallmark of cancer , 2010, Nature Reviews Molecular Cell Biology.
[53] Li-Huei Tsai,et al. Guiding neuronal cell migrations. , 2010, Cold Spring Harbor perspectives in biology.
[54] P. Wadsworth,et al. Mitotic functions of kinesin-5. , 2010, Seminars in cell & developmental biology.
[55] I. Vernos,et al. The Role of Hklp2 in the Stabilization and Maintenance of Spindle Bipolarity , 2009, Current Biology.
[56] J. Trent,et al. Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells , 2009, Clinical Cancer Research.
[57] R. Houlston,et al. A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2* , 2009, The Journal of Biological Chemistry.
[58] M. Masjedi,et al. The diagnostic value of Ki-67 and repp86 in distinguishing between benign and malignant mesothelial proliferations. , 2009, Archives of pathology & laboratory medicine.
[59] J. Gleeson,et al. Aurora A moonlights in neurite extension , 2009, Nature Cell Biology.
[60] A. Wynshaw-Boris,et al. An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics , 2009, Nature Cell Biology.
[61] R. Lotan,et al. Identification of Gene Signatures and Molecular Markers for Human Lung Cancer Prognosis using an In vitro Lung Carcinogenesis System , 2009, Cancer Prevention Research.
[62] T. Mitchison,et al. Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity , 2009, Current Biology.
[63] R. Medema,et al. Aurora-A and hBora join the game of Polo. , 2009, Cancer research.
[64] H. Shigeishi,et al. Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. , 2009, International journal of oncology.
[65] S. Gasser,et al. Crosstalk between histone modifications during the DNA damage response. , 2009, Trends in cell biology.
[66] A. Wilde,et al. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase , 2009, Journal of Cell Science.
[67] Christopher D. Scharer,et al. Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells , 2008, Journal of Translational Medicine.
[68] Lan Xu,et al. TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. , 2008, Toxicology.
[69] O. Gruss,et al. Meiotic Regulation of TPX2 Protein Levels Governs Cell Cycle Progression in Mouse Oocytes , 2008, PloS one.
[70] I. Vernos,et al. The Plant TPX2 Protein Regulates Prospindle Assembly before Nuclear Envelope Breakdown[W] , 2008, The Plant Cell Online.
[71] D. V. Von Hoff,et al. Pdx-1-Driven Overexpression of Aurora A Kinase Induces Mild Ductal Dysplasia of Pancreatic Ducts Near Islets in Transgenic Mice , 2008, Pancreas.
[72] S. Lens,et al. The Aurora kinase family in cell division and cancer. , 2008, Biochimica et biophysica acta.
[73] M. Mansukhani,et al. Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression , 2008, Genes, chromosomes & cancer.
[74] D. Pellman,et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. , 2008, Genes & development.
[75] A. Hyman,et al. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A , 2008, The Journal of cell biology.
[76] F. D. D. Fagagna. Living on a break: cellular senescence as a DNA-damage response , 2008, Nature Reviews Cancer.
[77] L. Tsai,et al. Ndel1 Controls the Dynein-mediated Transport of Vimentin during Neurite Outgrowth* , 2008, Journal of Biological Chemistry.
[78] Minh Dang Nguyen,et al. Ndel1 Promotes Axon Regeneration via Intermediate Filaments , 2008, PloS one.
[79] Jiri Bartek,et al. An Oncogene-Induced DNA Damage Model for Cancer Development , 2008, Science.
[80] E. Birney,et al. Pfam: the protein families database , 2013, Nucleic Acids Res..
[81] J. Caldwell,et al. Human Cep192 Is Required for Mitotic Centrosome and Spindle Assembly , 2007, Current Biology.
[82] M. Tilby,et al. γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation , 2007, PloS one.
[83] W. Klapper,et al. Regulation of repp86 stability by human Siah2. , 2007, Biochemical and biophysical research communications.
[84] F. Gergely,et al. Aurora-A: the maker and breaker of spindle poles , 2007, Journal of Cell Science.
[85] Jung-Ae Kim,et al. Heterochromatin is refractory to γ-H2AX modification in yeast and mammals , 2007, The Journal of cell biology.
[86] B. A. Ballif,et al. ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage , 2007, Science.
[87] K. Fukasawa,et al. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication , 2007, Oncogene.
[88] S. Fesik,et al. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. , 2007, Cancer research.
[89] K. Ribbeck,et al. Self-Organization of Anastral Spindles by Synergy of Dynamic Instability, Autocatalytic Microtubule Production, and a Spatial Signaling Gradient , 2007, PloS one.
[90] L. Tsai,et al. Spindle regulation in neural precursors of flies and mammals , 2007, Nature Reviews Neuroscience.
[91] M. Nagasawa,et al. Phospho-regulation of human protein kinase Aurora-A: analysis using anti-phospho-Thr288 monoclonal antibodies , 2006, Oncogene.
[92] W. Bonner,et al. γ-H2AX in Cancer Cells: A Potential Biomarker for Cancer Diagnostics, Prediction and Recurrence , 2006, Cell cycle.
[93] M. Malumbres,et al. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. , 2006, Carcinogenesis.
[94] C. Deng,et al. Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation , 2006, Oncogene.
[95] David M. Livingston,et al. The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly , 2006, Cell.
[96] C. Plass,et al. 20q11.1 amplification in giant‐cell tumor of bone: Array CGH, FISH, and association with outcome , 2006, Genes, chromosomes & cancer.
[97] Jomon Joseph. Ran at a glance , 2006, Journal of Cell Science.
[98] Z. Szallasi,et al. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers , 2006, Nature Genetics.
[99] P. Olive,et al. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. , 2006, DNA repair.
[100] E. Nigg,et al. HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes , 2006, Current Biology.
[101] T. Köcher,et al. HURP Is Part of a Ran-Dependent Complex Involved in Spindle Formation , 2006, Current Biology.
[102] Erich A Nigg,et al. Phosphoproteome analysis of the human mitotic spindle. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[103] C. Fagerstrom,et al. Molecular Requirements for Kinetochore-Associated Microtubule Formation in Mammalian Cells , 2006, Current Biology.
[104] D. Lin,et al. Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.
[105] P. Lavia,et al. A Functional Interplay Between Aurora-A, Plk1 and TPX2 at Spindle Poles: Plk1 Controls Centrosomal Localization of Aurora-A and TPX2 Spindle Association , 2006, Cell cycle.
[106] Yixian Zheng,et al. Aurora A Kinase-Coated Beads Function as Microtubule-Organizing Centers and Enhance RanGTP-Induced Spindle Assembly , 2005, Current Biology.
[107] S. Stewart,et al. Anaphase-Promoting Complex/Cyclosome Controls the Stability of TPX2 during Mitotic Exit , 2005, Molecular and Cellular Biology.
[108] E. Nkenke,et al. Restricted-Expressed Proliferation–Associated Protein (Repp86) Expression in Squamous Cell Carcinoma of the Oral Cavity , 2005, Strahlentherapie und Onkologie.
[109] Wieland B Huttner,et al. Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. , 2005, Current opinion in cell biology.
[110] L. Lim,et al. The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. , 2005, Molecular cell.
[111] R. Agarwala,et al. Protein database searches using compositionally adjusted substitution matrices , 2005, The FEBS journal.
[112] Erica A. Golemis,et al. The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome , 2005, Nature Cell Biology.
[113] L. Chin,et al. High-resolution genomic profiles of human lung cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[114] Chi-Ying F. Huang,et al. Phosphorylation and Stabilization of HURP by Aurora-A: Implication of HURP as a Transforming Target of Aurora-A , 2005, Molecular and Cellular Biology.
[115] Min Liu,et al. Genes transactivated by hepatitis C virus core protein, a microarray assay. , 2005, World journal of gastroenterology.
[116] E. Peterman,et al. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks , 2005, Nature.
[117] Eran Perlson,et al. Vimentin-Dependent Spatial Translocation of an Activated MAP Kinase in Injured Nerve , 2005, Neuron.
[118] A. Kloepfer,et al. Requirements for the destruction of human Aurora-A , 2004, Journal of Cell Science.
[119] H. Saya,et al. Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models , 2004, Oncogene.
[120] R. Pepperkok,et al. Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. , 2004, Molecular biology of the cell.
[121] Ryoma Ohi,et al. The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly , 2004, Cell.
[122] L. Chin,et al. High-resolution characterization of the pancreatic adenocarcinoma genome , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[123] D. Brautigan,et al. Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[124] B. Monsarrat,et al. Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition , 2004, Journal of Cell Science.
[125] M. Jordan,et al. Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.
[126] Yixian Zheng,et al. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. , 2004, Genes & development.
[127] P. Lavia,et al. Mitotic Functions of the Ran GTPase Network: the Importance of Being in the Right Place at the Right Time , 2004, Cell cycle.
[128] Richard Bayliss,et al. Determinants for Aurora-A Activation and Aurora-B Discrimination by TPX2 , 2004, Cell cycle.
[129] A. Wilde,et al. Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation , 2003, Journal of Cell Science.
[130] E. Nigg,et al. Regulation of Aurora-A kinase on the mitotic spindle , 2003, Chromosoma.
[131] Richard Bayliss,et al. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. , 2003, Molecular cell.
[132] H. Saya,et al. Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells , 2003, Cell.
[133] Weifeng Chen,et al. [Expression and clinical significance of hepatocellular cancer antigen genes in human hepatocellular carcinoma]. , 2003, Zhonghua wai ke za zhi [Chinese journal of surgery].
[134] B. Quimby,et al. The small GTPase Ran: interpreting the signs. , 2003, Current opinion in cell biology.
[135] F. Bertoni,et al. Malignancy in giant cell tumor of bone , 2003, Cancer.
[136] A. Hoenger,et al. Importin α‐regulated nucleation of microtubules by TPX2 , 2003 .
[137] F. Berthold,et al. Repp86 expression and outcome in patients with neuroblastoma. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[138] A. Chiu,et al. Prognostic significance of hepatoma-up-regulated protein expression in patients with urinary bladder transitional cell carcinoma. , 2003, Anticancer research.
[139] Patrick A. Eyers,et al. A Novel Mechanism for Activation of the Protein Kinase Aurora A , 2003, Current Biology.
[140] Dirk Görlich,et al. Characterization of Ran‐driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation , 2003, The EMBO journal.
[141] C. Prigent,et al. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly , 2003, Nature Cell Biology.
[142] Karsten Weis,et al. Regulating Access to the Genome Nucleocytoplasmic Transport throughout the Cell Cycle , 2003, Cell.
[143] Friedrich Buck,et al. repp86: A human protein associated in the progression of mitosis. , 2003, Molecular cancer research : MCR.
[144] Chi-Ying F. Huang,et al. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma , 2003, Oncogene.
[145] T. Kapoor,et al. hTPX2 Is Required for Normal Spindle Morphology and Centrosome Integrity during Vertebrate Cell Division , 2002, Current Biology.
[146] L. Amundadottir,et al. Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[147] R. Pepperkok,et al. Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells , 2002, Nature Cell Biology.
[148] J. Ruderman,et al. Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. , 2002, Genes & development.
[149] Roman Körner,et al. Human TPX2 is required for targeting Aurora-A kinase to the spindle , 2002, The Journal of cell biology.
[150] M. Dasso. The Ran GTPase: Theme and Variations , 2002, Current Biology.
[151] M. Hetzer,et al. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly , 2002, Nature Cell Biology.
[152] A. Chiu,et al. Potential molecular marker for detecting transitional cell carcinoma. , 2002, Urology.
[153] T. Urano,et al. Degradation of human Aurora‐A protein kinase is mediated by hCdh1 , 2002, FEBS letters.
[154] Karsten Weis,et al. Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts , 2002, Science.
[155] P. Meraldi,et al. Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells , 2002, The EMBO journal.
[156] P. Clarke,et al. Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? , 2001, Trends in cell biology.
[157] W. Marshall,et al. Stay tuned for some importin news about spindle assembly. , 2001, Trends in cell biology.
[158] J. Kahana,et al. Some Importin News About Spindle Assembly , 2001, Science.
[159] Yixian Zheng,et al. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities , 2001, Nature Cell Biology.
[160] Iain W. Mattaj,et al. Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly , 2001, Nature Cell Biology.
[161] I. Vernos,et al. Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity , 2001, Cell.
[162] Karsten Weis,et al. Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly , 2001, Cell.
[163] Yixian Zheng,et al. Role of Importin-β in Coupling Ran to Downstream Targets in Microtubule Assembly , 2001, Science.
[164] E. Lees,et al. The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation , 2000, Oncogene.
[165] C. Prigent,et al. The Xenopus laevis aurora/Ip11p-related kinase pEg2 participates in the stability of the bipolar mitotic spindle. , 2000, Experimental cell research.
[166] Eric Karsenti,et al. Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization , 2000, The Journal of cell biology.
[167] J. Arends,et al. A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization , 1999, FEBS letters.
[168] J. Yokota,et al. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. , 1999, Genomics.
[169] E. Rogakou,et al. Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo , 1999, The Journal of cell biology.
[170] W. Jonat,et al. Prognostic significance of a novel proliferation marker, anti-repp 86, for endometrial carcinoma: a multivariate study. , 1999, Human pathology.
[171] Iain W. Mattaj,et al. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation , 1999, Nature.
[172] R. Parwaresch,et al. Assignment1 of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization , 1999, Cytogenetic and Genome Research.
[173] R. Uzbekov,et al. The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5* , 1999, The Journal of Biological Chemistry.
[174] Christine Nowak,et al. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport , 1999, Nature.
[175] K. Kinzler,et al. Genetic instabilities in human cancers , 1998, Nature.
[176] K. Kinzler,et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. , 1998, Science.
[177] I. Vernos,et al. Localization of the Kinesin-like Protein Xklp2 to Spindle Poles Requires a Leucine Zipper, a Microtubule-associated Protein, and Dynein , 1998, The Journal of cell biology.
[178] R. White,et al. BRCA1 is associated with the centrosome during mitosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[179] Brian Schryver,et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers , 1998, The EMBO journal.
[180] E. Rogakou,et al. DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.
[181] Thomas L. Madden,et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.
[182] R. Parwaresch,et al. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. , 1997, Blood.
[183] S. Kotani,et al. Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1* , 1997, The Journal of Biological Chemistry.
[184] I. Vernos,et al. Xklp2, a Novel Xenopus Centrosomal Kinesin-like Protein Required for Centrosome Separation during Mitosis , 1996, Cell.
[185] K. Kinzler,et al. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. , 1995, Cancer research.
[186] R. Goody,et al. The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1. , 1995, Biochemistry.
[187] D. Glover,et al. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles , 1995, Cell.
[188] F. Bischoff,et al. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[189] I. Vernos,et al. Multiple kinesin-like transcripts in Xenopus oocytes. , 1993, Developmental biology.
[190] M. Dasso. RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. , 1993, Trends in biochemical sciences.
[191] F. Bischoff,et al. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1 , 1991, Nature.
[192] A. Demchuk,et al. Targeting Protein for Xenopus kinesin like protein 2 ( TPX 2 ) regulates gamma-H 2 AX levels upon ionizing radiation , 2012 .
[193] F. Del Bene. Interkinetic nuclear migration: cell cycle on the move , 2011, The EMBO journal.
[194] S. Jackson,et al. The mitotic DNA damage response marks DNA double strand breaks with early signaling events , 2011 .
[195] H. Shigeishi,et al. Expression of TPX2 in salivary gland carcinomas. , 2009, Oncology reports.
[196] H. Yoshida,et al. Giant cell tumor of bone , 2004, Virchows Archiv A.
[197] A. Hoenger,et al. Importin alpha-regulated nucleation of microtubules by TPX2. , 2003, The EMBO journal.
[198] J. Kahana,et al. Cell cycle. Some importin news about spindle assembly. , 2001, Science.
[199] C. Waterman-Storer,et al. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. , 2001, Cell.
[200] I. Vernos,et al. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. , 2001, Cell.
[201] A. Merdes,et al. Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. , 2001, Science.
[202] U. Kutay,et al. Transport between the cell nucleus and the cytoplasm. , 1999, Annual review of cell and developmental biology.
[203] I. Mattaj,et al. Nucleocytoplasmic transport: the soluble phase. , 1998, Annual review of biochemistry.