Squamous carcinoma of the external auditory canal: a different approach.

Squamous carcinoma of the external ear canal is a rare disease and a challenge to treat. Some controversy exists regarding the best options for treatment. Reported 5-year survival varies between 35% and 63%. Since 1976, we have adopted a conservative approach to these tumours, with patients undergoing a specific protocol of meticulous tumour debulking followed by a course of repeated topical 5-fluoro-uracil (5-FU) cream application and necrotectomy. Data was collected prospectively. From 1976 to 1998, 23 patients underwent primary treatment according to our protocol. Nine patients had T1 disease whereas six had T2 and eight had T3 disease. The 5- and 10-year overall survivals were 74% and 60% respectively. These results compare very favourably with those in the literature and surgical debulking with topical 5-FU and necrotectomy remains our primary treatment of choice for squamous cell carcinoma of the external auditory canal.

[1]  P. Knegt,et al.  Adenocarcinoma of the ethmoidal sinus complex: surgical debulking and topical fluorouracil may be the optimal treatment. , 2001, Archives of otolaryngology--head & neck surgery.

[2]  L. Kowalski,et al.  Prognostic factors in carcinoma of the external auditory canal. , 1997, Archives of otolaryngology--head & neck surgery.

[3]  J. Austin,et al.  Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. , 1994, Archives of otolaryngology--head & neck surgery.

[4]  M. Koriwchak Temporal bone cancer. , 1993, The American journal of otology.

[5]  R. Tiwari,et al.  Temporal bone resections for carcinoma of the middle ear and the external ear canal. , 1992, American journal of surgery.

[6]  D. Kamerer,et al.  Squamous Cell Carcinoma of the External Auditory Meatus (Canal) , 1989, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  S. E. Kinney Squamous cell carcinoma of the external auditory canal. , 1989, The American journal of otology.

[8]  S. E. Kinney,et al.  Malignancies of the external ear canal and temporal bone: Surgical techniques and results , 1987, The Laryngoscope.

[9]  M. Koken,et al.  Local Administration of Various Cytostatic Drugs after Subcutaneous Immunization Enhances Delayed‐Type Hypersensitivity Reaction to Sheep Red Blood Cells in Mice , 1986, Scandinavian journal of immunology.

[10]  M. Mccormick,et al.  Carcinoma of the external auditory meatus and middle ear , 1985, The Journal of Laryngology & Otology.

[11]  M. D. De Boer,et al.  Carcinoma of the paranasal sinuses results of a prospective pilot study , 1985 .

[12]  P. Stell Carcinoma of the external auditory meatus and middle ear. , 1984, Clinical otolaryngology and allied sciences.

[13]  R. Scheper,et al.  Local administration of cytostatic drug 4-hydroperoxy-cyclophosphamide (4-HPCY) facilitates cell-mediated immune reactions. , 1984, Clinical and experimental immunology.

[14]  D. Schuller,et al.  Malignancies of the ear , 1976, The Laryngoscope.

[15]  R. Bast,et al.  Regression of established tumors and induction of tumor immunity by intratumor chemotherapy. , 1976, Journal of the National Cancer Institute.

[16]  M. Pierce,et al.  Carcinoma of the external auditory canal , 1976, The Laryngoscope.

[17]  M. Johns,et al.  Squamous cell carcinoma of the external auditory canal. A clinicopathologic study of 20 cases. , 1974, Archives of otolaryngology.

[18]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[19]  W. O. Lodge,et al.  Malignant Tumors of the Temporal Bone one , 1955 .

[20]  J. S. Lewis Temporal bone resection. Review of 100 cases. , 1975, Archives of otolaryngology.