The benefits and risks of exercise training in patients with chronic coronary artery disease.

WILLIAM Heberden, in his Commentaries on the History and Cure of Diseases published in 1802, had "little or nothing to advance..." for the treatment of angina pectoris but did know of one patient "who set himself a task of sawing wood for half an hour every day and was nearly cured." 1 Heberden's observation that physical training can nearly cure angina in some patients has been confirmed in recent studies, 2-4 and physical training remains one of the most effective methods for improving the functional capacity and psychological well-being of selected patients with coronary artery disease (CAD). This article summarizes the effect of CAD on exercise tolerance and the benefits and risks of exercise training in patients with CAD. ACUTE CARDIOVASCULAR RESPONSE TO EXERCISE Healthy Subjects A brief review of the normal cardiovascular response to exercise is necessary to understand how CAD alters exercise performance. Functional capacity during dynamic exercise

[1]  L. Rowell Human Circulation: Regulation During Physical Stress , 1986 .

[2]  S. Camp,et al.  Cardiovascular complications of outpatient cardiac rehabilitation programs. , 1986, JAMA.

[3]  P. Thompson The Cardiovascular Risks of Cardiac Rehabilitation , 1985 .

[4]  W. Shen,et al.  Effects of nifedipine on systemic and regional oxygen transport and metabolism at rest and during exercise. , 1985, Circulation.

[5]  A. Bove,et al.  Proximal coronary vasomotor reactivity after exercise training in dogs. , 1985, Circulation.

[6]  R. Dishman Medical psychology in exercise and sport. , 1985, The Medical clinics of North America.

[7]  L. Horwitz,et al.  Effect of beta blockade and intrinsic sympathomimetic activity on exercise performance. , 1984, The American journal of cardiology.

[8]  W. Haskell,et al.  Home versus group exercise training for increasing functional capacity after myocardial infarction. , 1984, Circulation.

[9]  V. Froelicher,et al.  A randomized trial of exercise training in patients with coronary heart disease. , 1984, JAMA.

[10]  K. Weber,et al.  Effect of hydralazine on perfusion and metabolism in the leg during upright bicycle exercise in patients with heart failure. , 1983, Circulation.

[11]  J. Holloszy,et al.  Effect of 12 Months of Intense Exercise Training on Stroke Volume in Patients with Coronary Artery Disease , 1983, Circulation.

[12]  M. Frick,et al.  Persistent Improvement After Coronary Bypass Surgery: Ergometric and Angiographic Correlations at 5 Years , 1983, Circulation.

[13]  I. Lukšić,et al.  Cardiac Rehabilitation after Acute Myocardial Infarction , 1983 .

[14]  E. Coyle,et al.  Cardiac effects of prolonged and intense exercise training in patients with coronary artery disease. , 1982, The American journal of cardiology.

[15]  L. Horwitz,et al.  Attenuation of Exercise Conditioning by Beta‐adrenergic Blockade , 1982, Circulation.

[16]  A. Wallace,et al.  Exercise responses before and after physical conditioning in patients with severely depressed left ventricular function. , 1982, The American journal of cardiology.

[17]  D L DeMets,et al.  Secondary prevention after myocardial infarction: a review of long-term trials. , 1982, Progress in cardiovascular diseases.

[18]  H. Denolin,et al.  Rehabilitation and secondary prevention of patients after acute myocardial infarction. WHO collaborative study. , 1982, Advances in cardiology.

[19]  W. G. Squires,et al.  Demonstration of Training Effect During Chronic β‐adrenergic Blockade in Patients with Coronary Artery Disease , 1981, Circulation.

[20]  P. Thompson,et al.  Effect of exercise training on the untrained limb exercise performance of men with angina pectoris. , 1981, The American journal of cardiology.

[21]  P. Thompson,et al.  Comparison of the results and reproducibility of arm and leg exercise tests in men with angina pectoris. , 1981, The American journal of cardiology.

[22]  G. H. Hartung,et al.  Exercise training in post-myocardial infarction patients: comparison of results with high risk coronary and post-bypass patients. , 1981, Archives of physical medicine and rehabilitation.

[23]  R. Shephard,et al.  Effects of physical training on cardiovascular function following myocardial infarction. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[24]  D. Cunningham,et al.  Exercise and Human Collateralization: An Angiographic and Scintigraphic Assessment , 1979, Circulation.

[25]  H. Yasue,et al.  Circadian Variation of Exercise Capacity in Patients with Prinzmetal's Variant Angina: Role of Exercise‐induced Coronary Arterial Spasm , 1979, Circulation.

[26]  B. Franklin,et al.  Low intensity physical conditioning: effects on patients with coronary heart disease. , 1978, Archives of physical medicine and rehabilitation.

[27]  F. Nagle,et al.  Aortocoronary bypass surgery: effects of surgery and 32 months of physical conditioning on treadmill performance. , 1978, Archives of physical medicine and rehabilitation.

[28]  YANG WANG,et al.  The Rate-Pressure Product as an Index of Myocardial Oxygen Consumption during Exercise in Patients with Angina Pectoris , 1978, Circulation.

[29]  Michael L. Pollock,et al.  Health and Fitness Through Physical Activity , 1978 .

[30]  M. Oldham,et al.  Effects of exercise on coronary collateralization--angiographic studies of six patients in a supervised exercise program. , 1976, Medicine and science in sports.

[31]  M Pagani,et al.  Cardiovascular adjustments to exercise: hemodynamics and mechanisms. , 1976, Progress in cardiovascular diseases.

[32]  F. Klocke,et al.  Coronary blood flow in man. , 1976, Progress in cardiovascular diseases.

[33]  J. Clausen,et al.  Circulatory adjustments to dynamic exercise and effect of physical training in normal subjects and in patients with coronary artery disease. , 1976, Progress in cardiovascular diseases.

[34]  R. Frye,et al.  One-year graduated exercise program for men with angina pectoris. Evaluation by physiologic studies and coronary arteriography. , 1976, Mayo Clinic proceedings.

[35]  J. Clausen,et al.  Heart Rate and Arterial Blood Pressure during Exercise in Patients with Angina Pectoris: Effects of Training and of Nitroglycerin , 1976, Circulation.

[36]  R. Petitclerc,et al.  Effect of physical training on treadmill exercise capacity, collateral circulation and progression of coronary disease. , 1974, The American journal of cardiology.

[37]  D. N. Sim,et al.  Investigation of the physiological basis for increased exercise threshold for angina pectoris after physical conditioning. , 1974, The Journal of clinical investigation.

[38]  A. DeMaria,et al.  Indirect assessment of myocardial oxygen consumption in the evaluation of mechanisms and therapy of angina pectoris. , 1974, The American journal of cardiology.

[39]  W. C. Adams,et al.  Long-term physiologic adaptations to exercise with special reference to performance and cardiorespiratory function in health and disease. , 1974, The American journal of cardiology.

[40]  J. Wahren,et al.  Influence of Body Position on the Anginal Threshold during Leg Exercise , 1974, European journal of clinical investigation.

[41]  S. Epstein,et al.  Circulatory and symptomatic effects of physical training in patients with coronary-artery disease and angina pectoris. , 1972, The New England journal of medicine.

[42]  R. Bruce,et al.  Increased Arteriovenous Oxygen Difference After Physical Training in Coronary Heart Disease , 1971, Circulation.

[43]  J. Mitchell,et al.  Maximal oxygen uptake. , 1971, The New England journal of medicine.