Innate lymphoid cells — how did we miss them?

[1]  Eric Vivier,et al.  Innate lymphoid cells — a proposal for uniform nomenclature , 2013, Nature Reviews Immunology.

[2]  Y. Belkaid,et al.  Distinct requirements for T-bet in gut innate lymphoid cells , 2012, The Journal of experimental medicine.

[3]  David Voehringer,et al.  The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. , 2012, Immunity.

[4]  Graham M Lord,et al.  The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells , 2012, Immunity.

[5]  Hergen Spits,et al.  The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. , 2012, Immunity.

[6]  Fumio Takei,et al.  Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. , 2012, Immunity.

[7]  Natalie A. Roberts,et al.  Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue , 2012, The Journal of Immunology.

[8]  F. Bushman,et al.  Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria , 2012, Science.

[9]  A. Diefenbach,et al.  Multifaceted roles of interleukin-7 signaling for the development and function of innate lymphoid cells. , 2012, Seminars in immunology.

[10]  A. McKenzie,et al.  Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population. , 2012, Immunity.

[11]  Marjolein J. W. de Bruijn,et al.  Pulmonary innate lymphoid cells are major producers of IL‐5 and IL‐13 in murine models of allergic asthma , 2012, European journal of immunology.

[12]  G. Eberl,et al.  Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells , 2012, The Journal of experimental medicine.

[13]  Fumio Takei,et al.  Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. , 2012, Immunity.

[14]  Freddy Radtke,et al.  Rorα is essential for nuocyte development , 2011, Nature Immunology.

[15]  H. Kita,et al.  IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs , 2012, The Journal of Immunology.

[16]  C. Garlanda,et al.  AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch , 2011, Nature Immunology.

[17]  Liang Zhou,et al.  The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. , 2012, Immunity.

[18]  K. Tsuneyama,et al.  Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity , 2012, The Journal of Immunology.

[19]  G. Anderson,et al.  Lymphoid Tissue Inducer Cells: Pivotal Cells in the Evolution of CD4 Immunity and Tolerance? , 2011, Front. Immun..

[20]  R. Locksley,et al.  Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity , 2011, Nature Immunology.

[21]  A. McKenzie,et al.  Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. , 2012, The Journal of allergy and clinical immunology.

[22]  Dirk E. Smith,et al.  Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. , 2012, The Journal of allergy and clinical immunology.

[23]  E. Hobeika,et al.  Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles , 2011, Science.

[24]  David Artis,et al.  Cutting Edge: Natural Helper Cells Derive from Lymphoid Progenitors , 2011, The Journal of Immunology.

[25]  S. Johnston,et al.  Asthma exacerbations: Origin, effect, and prevention , 2011, Journal of Allergy and Clinical Immunology.

[26]  A. McKenzie,et al.  Nuocytes: expanding the innate cell repertoire in type‐2 immunity , 2011, Journal of leukocyte biology.

[27]  J. Renauld,et al.  IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. , 2011, The Journal of allergy and clinical immunology.

[28]  Hergen Spits,et al.  Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 , 2011, Nature Immunology.

[29]  David Artis,et al.  Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus , 2011, Nature Immunology.

[30]  A. McKenzie,et al.  Reciprocal expression of IL‐25 and IL‐17A is important for allergic airways hyperreactivity , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[31]  A. Cumano,et al.  Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells , 2011, Nature Immunology.

[32]  B. Becher,et al.  IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease , 2011, PloS one.

[33]  Ya-Jen Chang,et al.  Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity , 2011, Nature Immunology.

[34]  Fiona Powrie,et al.  Intestinal homeostasis and its breakdown in inflammatory bowel disease , 2011, Nature.

[35]  S. Travis,et al.  IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease , 2011, The Journal of experimental medicine.

[36]  Gordon K Smyth,et al.  Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages , 2011, The EMBO journal.

[37]  M. Willart,et al.  Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. , 2011, American journal of respiratory and critical care medicine.

[38]  G. Eberl,et al.  RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota , 2011, Nature Immunology.

[39]  R. Flavell,et al.  Recent advances in IL-22 biology. , 2011, International immunology.

[40]  M. Hirano,et al.  A thymus candidate in lampreys , 2011, Nature.

[41]  I. Taniuchi,et al.  Runx1/Cbfβ2 Complexes Are Required for Lymphoid Tissue Inducer Cell Differentiation at Two Developmental Stages , 2011, The Journal of Immunology.

[42]  D. Artis,et al.  CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. , 2011, Immunity.

[43]  M. Si-Tahar,et al.  Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells , 2011, The Journal of experimental medicine.

[44]  M. Caligiuri,et al.  Innate or Adaptive Immunity? The Example of Natural Killer Cells , 2011, Science.

[45]  高山 哲朗.  Imbalance of NKp44[+]NKp46[-] and NKp44[-]NKp46[+] natural killer cells in the intestinal mucosa of patients with Crohn's disease , 2011 .

[46]  H. Spits,et al.  The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling , 2011, Nature Immunology.

[47]  U. Pannicke,et al.  Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. , 2010, Immunity.

[48]  D. Wiest,et al.  Faculty Opinions recommendation of Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. , 2010 .

[49]  Gérard Eberl,et al.  Lineage Relationship Analysis of RORγt+ Innate Lymphoid Cells , 2010, Science.

[50]  T. Hibi,et al.  Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease. , 2010, Gastroenterology.

[51]  F. Nestle,et al.  Faculty Opinions recommendation of Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. , 2010 .

[52]  M. Caligiuri,et al.  Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. , 2010, Immunity.

[53]  David J. Erle,et al.  Systemically dispersed innate IL-13–expressing cells in type 2 immunity , 2010, Proceedings of the National Academy of Sciences.

[54]  M. Colonna,et al.  Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity , 2010, Proceedings of the National Academy of Sciences.

[55]  J. Renauld,et al.  IL-22 defines a novel immune pathway of antifungal resistance , 2010, Mucosal Immunology.

[56]  B. Schnyder,et al.  Interleukin-22 is a negative regulator of the allergic response. , 2010, Cytokine.

[57]  C. Secombes,et al.  Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated. , 2010, Developmental and comparative immunology.

[58]  W. Paul,et al.  Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells , 2010, Science.

[59]  J. D. Di Santo,et al.  IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors , 2010, The Journal of experimental medicine.

[60]  A. McKenzie,et al.  Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity , 2010, Nature.

[61]  H. Spits,et al.  Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells , 2010, The Journal of experimental medicine.

[62]  Tak W. Mak,et al.  Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo , 2009, The Journal of experimental medicine.

[63]  Tsutomu Takeuchi,et al.  Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells , 2009, Nature.

[64]  Mark Coles,et al.  The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development , 2009, Nature Immunology.

[65]  B. Venkatesh,et al.  Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates , 2009, Cell.

[66]  M. Caligiuri,et al.  Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. , 2009, Blood.

[67]  J. Lennerz,et al.  A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity , 2009, Nature.

[68]  C. Tato,et al.  Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22 , 2009, The Journal of experimental medicine.

[69]  H. Spits,et al.  Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells , 2009, Nature Immunology.

[70]  J. Banchereau,et al.  Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin , 2009, Nature Immunology.

[71]  Andreas Diefenbach,et al.  RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells , 2009, Nature Immunology.

[72]  Shinichiro Sawa,et al.  Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. , 2008, Immunity.

[73]  N. Hayashi,et al.  Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish , 2008, Immunogenetics.

[74]  T. Junt,et al.  Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone , 2008, Nature Immunology.

[75]  J. Buer,et al.  The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins , 2008, Nature.

[76]  S. Sa,et al.  Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.

[77]  Chen Dong,et al.  T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.

[78]  K. Takeda,et al.  Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation. , 2008, International immunology.

[79]  S. Tsutsui,et al.  Lamprey (Lethenteron japonicum) IL-17 upregulated by LPS-stimulation in the skin cells , 2007, Immunogenetics.

[80]  N. Huntington,et al.  Developmental pathways that generate natural-killer-cell diversity in mice and humans , 2007, Nature Reviews Immunology.

[81]  B. Kee,et al.  Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity , 2007, The Journal of experimental medicine.

[82]  Kathryn E. Crosier,et al.  The zebrafish retinoid-related orphan receptor (ror) gene family. , 2007, Gene expression patterns : GEP.

[83]  J. D. Di Santo,et al.  Bone marrow versus thymic pathways of natural killer cell development , 2006, Immunological reviews.

[84]  D. Voehringer,et al.  Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system , 2006, The Journal of experimental medicine.

[85]  Niamh E Mangan,et al.  Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion , 2006, The Journal of experimental medicine.

[86]  Galina V. Glazko,et al.  Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate , 2005, Science.

[87]  Takashi Suzuki,et al.  Variable lymphocyte receptors in hagfish. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[88]  F. Finkelman,et al.  Interleukin‐4‐ and interleukin‐13‐mediated host protection against intestinal nematode parasites , 2004, Immunological reviews.

[89]  D. Littman,et al.  Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt+ Cells , 2004, Science.

[90]  P. Mannon,et al.  Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. , 2004, The Journal of clinical investigation.

[91]  Yongwon Choi,et al.  An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells , 2004, Nature Immunology.

[92]  F. Grosveld,et al.  GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells , 2003 .

[93]  R. Blumberg,et al.  Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. , 2002, Immunity.

[94]  Philip Smith,et al.  IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13. , 2002, Immunity.

[95]  R. Coffman,et al.  New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-251 , 2002, The Journal of Immunology.

[96]  B. Finlay,et al.  Mice Lacking T and B Lymphocytes Develop Transient Colitis and Crypt Hyperplasia yet Suffer Impaired Bacterial Clearance during Citrobacter rodentium Infection , 2002, Infection and Immunity.

[97]  M. Leach,et al.  IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. , 2001, Immunity.

[98]  S. Nishikawa,et al.  Expression of α4β7 Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells1 , 2001, The Journal of Immunology.

[99]  Irving L. Weissman,et al.  The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45+CD4+CD3− Cells, As Well As Macrophages1 , 2001, The Journal of Immunology.

[100]  S. Nishikawa,et al.  IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. , 1999, International immunology.

[101]  Ahmed Mansouri,et al.  Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2 , 1999, Nature.

[102]  F. Brombacher,et al.  Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses , 1998, Current Biology.

[103]  T. Iwanaga,et al.  Generation of intestinal T cells from progenitors residing in gut cryptopatches. , 1998, Science.

[104]  G. McKenzie,et al.  A distinct role for interleukin-13 in Th2-cell-mediated immune responses , 1998, Current Biology.

[105]  I. Weissman,et al.  Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. , 1997, Immunity.

[106]  I. Weissman,et al.  A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Neurath,et al.  Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. , 1996, Journal of immunology.

[108]  I. Forgacs.  GASTROENTEROLOGY , 1988, The Lancet.

[109]  R. Herberman,et al.  Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells , 1975, International journal of cancer.

[110]  R. Kiessling,et al.  „Natural”︁ killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell , 1975, European journal of immunology.