Concentration‐effect relationships with major and minor tranquilizers

Relationships between the effects of centrally acting drugs and concentrations of the pharmacologically active moleeules in plasma can take a wide variety of forms, ranging from simple direct relationships, for instance, those involving effects on reaction time, to extremely complex relationships, for instance, those involving clinical rating of psychopathology. A number of forms of relationships have been revealed with glutethimide, nordiazepam, and chlorpromazine, and a brief review is presented of the current status of studies of the relationship between concentration and effect for these compounds.