Incidence and Predictors of Seizures in Patients with Alzheimer's Disease

Summary:  Purpose: To determine cumulative incidence and predictors of new‐onset seizures in mild Alzheimer's disease (AD) with a cohort followed prospectively. Limited information is available on the incidence of seizures, and no reports exist of seizure predictors in AD patients.

[1]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[2]  L Forsgren,et al.  Incidence and Clinical Characterization of Unprovoked Seizures in Adults: A Prospective Population‐Based Study , 1996, Epilepsia.

[3]  S. M. Sumi,et al.  Myoclonus, Seizures, and Paratonia in Alzheimer Disease , 1990, Alzheimer disease and associated disorders.

[4]  B. Reed,et al.  Clinical aspects of Alzheimer's disease in black and white patients. , 1998, Journal of the National Medical Association.

[5]  H. Soininen,et al.  Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease , 1996, Neurology.

[6]  Prognosis Guidelines for Epidemiologic Studies on Epilepsy , 1993, Epilepsia.

[7]  R. Levy,et al.  Neurologic signs in Alzheimer's disease. Results of a prospective clinical and neuropathologic study. , 1992, Archives of neurology.

[8]  M. Albert,et al.  Age at onset of Alzheimer's disease , 1994, Neurology.

[9]  W. Hauser,et al.  Major depression is a risk factor for seizures in older adults , 2000, Annals of neurology.

[10]  M. Albert,et al.  Multicenter Study of Predictors of Disease Course in Alzheimer Disease (the “Predictors Study”). I. Study Design, Cohort Description, and Intersite Comparisons , 1993, Alzheimer disease and associated disorders.

[11]  W. Hauser,et al.  Hypertension and the risk of new‐onset unprovoked seizures , 1993, Neurology.

[12]  W. Hauser,et al.  Dementia and adult-onset unprovoked seizures , 1996, Neurology.

[13]  W. Hauser,et al.  Seizures and myoclonus in patients with Alzheimer's disease , 1986, Neurology.

[14]  W. Hauser,et al.  Severe, Uncontrolled Hypertension and Adult‐Onset Seizures: A Case‐Control Study in Rochester, Minnesota , 1996, Epilepsia.

[15]  L. Nyström,et al.  An incident case-referent study of epileptic seizures in adults , 1990, Epilepsy Research.

[16]  Yaakov Stern,et al.  Modified Mini-Mental State Examination: Validity and Reliability , 1987 .

[17]  J. Morris,et al.  Advanced Alzheimer's disease is a risk factor for late-onset seizures. , 1990, Archives of neurology.

[18]  A. Hofman,et al.  Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease , 2004, Journal of Neurology.

[19]  G. Schroth,et al.  Early diagnosis of herpes simplex encephalitis by MRI , 1987, Neurology.