Elsevier Editorial System(tm) for Carbohydrate Polymers Manuscript Draft Manuscript Number: Title: Ulvan-Chitosan Polyelectrolyte Complexes as Matrices for Biomineralization

Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study ALP mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to alkaline phosphatase (ALP) and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering. Suggested Reviewers: Håvard J. Haugen Department of Biomaterials, University of Oslo h.j.haugen@odont.uio.no Prof. Haugen is related to the field of biomaterials. Antonella Motta Dipartimento di Ingegneria Industriale , University Trento antonella.motta@unitn.it Prof. Motta is renowned for working on cell material interaction on carbohydrates. Jayakumar Rajadas Biomaterials and Advanced Drug Delivery Laboratory, Stanford University jayraja@stanford.edu Prof. Rajadas is related to the field of Biomaterials.

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