Experimental study on anti-inflammatory and immuno-regulating effect of kirenol

Objective To study the anti-inflammatory and immuno-regulating effect of kirenol. (Methods) Adjuvant arthritis rat model was made by means of Freunds complete adjuvant, then the changes of paw swelling, proliferation of splenic lymphocyte and T lymphocyte subpopulation ratio of adjuvant arthritis rats were observed. The anti-inflammatory effect of kirenol was evaluated using ear edema model induced by xylene and granuloma model induced by cotton balls, and further the effect of kirenol on specific and non-specific immune response was evaluated by delayed hypersensitivity of murine auricle swelling and serum hemolysin level test and carbon clearance rate in mice. Results Kirenol can inhibit paw swelling, boost up the proliferation of splenic lymphocyte of adjuvant arthritis rats, regulate T lymphocyte subpopulation ratio, and also can inhibit ear edema in mice, granuloma weight in rats, and specific immune response of normal mice.Conclusion Kirenol can control the primary and secondary paw swelling of adjuvant arthritis rats, inhibit acute and chronic inflammation, and regulate immunologic function.