论文信息 - Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic Hepatitis

Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic Hepatitis

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

[1] M. Ziol,et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. , 2003, Ultrasound in medicine & biology.

[2] T. Matsumura,et al. Breast disease: clinical application of US elastography for diagnosis. , 2006, Radiology.

[3] V. de Lédinghen,et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study , 2005, Gut.

[4] Tsuyoshi Shiina,et al. The impact of real-time tissue elasticity imaging (elastography) on the detection of prostate cancer: clinicopathological analysis , 2007, International Journal of Clinical Oncology.

[5] Dario Conte,et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease , 2007, Gut.

[6] Non-invasive evaluation of Hepatic Fibrosis in patients with Chronic Hepatitis C using Elastography , 2007 .

[7] M. Kudo,et al. Noninvasive Evaluation of Hepatic Fibrosis Using Serum Fibrotic Markers, Transient Elastography (FibroScan) and Real-Time Tissue Elastography , 2008, Intervirology.