False Alarm Reduction in Atrial Fibrillation Detection Using Deep Belief Networks

We propose and validate a novel method to reduce the false alarm (FA) rate caused by poor-quality electrocardiogram (ECG) signal measurement during atrial fibrillation (AFib) detection. A deep belief network is used to differentiate acceptable from unacceptable ECG segments. To validate the method, eight different levels of ECG quality are provided by artificially contaminating ECG records, from the MIT-BIH AFib database, with motion artifact from the MIT-BIH noise stress test database. ECG segments classified as “unacceptable,” in terms of signal quality, are restricted from AFib detection process. Results are evaluated for each level of quality and compared to AFib detection algorithm performance when ECGs of each level of quality are applied to it without performing any classification. Our results show that AFib detection performance for ECG with high signal-to-noise ratio (SNR) is minimally affected by this FA reduction approach. For clean ECG (no added noise), the AFib detection accuracy was 87%, without and with FA reduction. For ECG, with an SNR of −20 dB, the performance of AFib detection is markedly decreased with an accuracy of 58.7%; however, with FA reduction (using our method) the accuracy was increased to 81%.

[1]  M. Ezekowitz,et al.  2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. , 2014, Circulation.

[2]  Adrian D. C. Chan,et al.  Wavelet Distance Measure for Person Identification Using Electrocardiograms , 2008, IEEE Transactions on Instrumentation and Measurement.

[3]  L Glass,et al.  Automatic detection of atrial fibrillation using the coefficient of variation and density histograms of RR and ΔRR intervals , 2001, Medical and Biological Engineering and Computing.

[4]  Adrian D. C. Chan,et al.  Signal Quality Analysis of Ambulatory Electrocardiograms to Gate False Myocardial Ischemia Alarms , 2017, IEEE Transactions on Biomedical Engineering.

[5]  Willis J. Tompkins,et al.  A Real-Time QRS Detection Algorithm , 1985, IEEE Transactions on Biomedical Engineering.

[6]  D. Strauss,et al.  Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs , 2016, Physiological measurement.

[7]  Madhuchhanda Mitra,et al.  A Rough-Set-Based Inference Engine for ECG Classification , 2006, IEEE Transactions on Instrumentation and Measurement.

[8]  Michal Huptych,et al.  Data driven approach to ECG signal quality assessment using multistep SVM classification , 2011, 2011 Computing in Cardiology.

[9]  Kevin Englehart,et al.  Continuous multifunction myoelectric control using pattern recognition , 2003 .

[10]  Kemal Polat,et al.  Detection of ECG Arrhythmia using a differential expert system approach based on principal component analysis and least square support vector machine , 2007, Appl. Math. Comput..

[11]  Qiao Li,et al.  ECG Signal Quality During Arrhythmia and Its Application to False Alarm Reduction , 2013, IEEE Transactions on Biomedical Engineering.

[12]  H. Bozdogan Model selection and Akaike's Information Criterion (AIC): The general theory and its analytical extensions , 1987 .

[13]  Honglak Lee,et al.  Convolutional deep belief networks for scalable unsupervised learning of hierarchical representations , 2009, ICML '09.

[14]  Adrian D. C. Chan,et al.  Classifying measured electrocardiogram signal quality using deep belief networks , 2017, 2017 IEEE International Instrumentation and Measurement Technology Conference (I2MTC).

[15]  Chin-Teng Lin,et al.  An Intelligent Telecardiology System Using a Wearable and Wireless ECG to Detect Atrial Fibrillation , 2010, IEEE Transactions on Information Technology in Biomedicine.

[16]  Gari D. Clifford,et al.  A machine learning approach to multi-level ECG signal quality classification , 2014, Comput. Methods Programs Biomed..

[17]  Honglak Lee,et al.  Unsupervised feature learning for audio classification using convolutional deep belief networks , 2009, NIPS.

[18]  Sanjiv M Narayan,et al.  Diagnostic accuracy of irregularly irregular RR intervals in separating atrial fibrillation from atrial flutter. , 2006, The American journal of cardiology.

[19]  Jeroen J. Bax,et al.  Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). , 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[20]  S. Nizami,et al.  Implementation of Artifact Detection in Critical Care: A Methodological Review , 2013, IEEE Reviews in Biomedical Engineering.

[21]  Peter Glöckner,et al.  Why Does Unsupervised Pre-training Help Deep Learning? , 2013 .

[22]  Pascal Vincent,et al.  Representation Learning: A Review and New Perspectives , 2012, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[23]  A. Antoniadis,et al.  High Accuracy of Automatic Detection of Atrial Fibrillation Using Wavelet Transform of Heart Rate Intervals , 2002, Pacing and clinical electrophysiology : PACE.

[24]  Emma Pickwell-MacPherson,et al.  Automatic online detection of atrial fibrillation based on symbolic dynamics and Shannon entropy , 2014, BioMedical Engineering OnLine.

[25]  Adrian D. C. Chan,et al.  Identification of Contaminant Type in Surface Electromyography (EMG) Signals , 2014, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[26]  Miguel Á. Carreira-Perpiñán,et al.  On Contrastive Divergence Learning , 2005, AISTATS.

[27]  Fei-Yue Wang,et al.  Traffic Flow Prediction With Big Data: A Deep Learning Approach , 2015, IEEE Transactions on Intelligent Transportation Systems.

[28]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[29]  Adrian D. C. Chan,et al.  Gating of false identifications in electrocardiogram based biometric system , 2017, 2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[30]  Serkan Gurkan,et al.  Design of a Novel Efficient Human–Computer Interface: An Electrooculagram Based Virtual Keyboard , 2010, IEEE Transactions on Instrumentation and Measurement.

[31]  G. Kay,et al.  Hemodynamic effects of an irregular sequence of ventricular cycle lengths during atrial fibrillation. , 1997, Journal of the American College of Cardiology.

[32]  Vaidotas Marozas,et al.  Low-complexity detection of atrial fibrillation in continuous long-term monitoring , 2015, Comput. Biol. Medicine.

[33]  G D Clifford,et al.  Signal quality indices and data fusion for determining clinical acceptability of electrocardiograms , 2012, Physiological measurement.

[34]  L. Biel,et al.  ECG analysis: a new approach in human identification , 1999, IMTC/99. Proceedings of the 16th IEEE Instrumentation and Measurement Technology Conference (Cat. No.99CH36309).

[35]  Robert Koprowski,et al.  Machine learning, medical diagnosis, and biomedical engineering research - commentary , 2014, BioMedical Engineering OnLine.

[36]  Andrzej Wolczowski,et al.  Towards an EMG-Controlled Prosthetic Hand Using a 3-D Electromagnetic Positioning System , 2007, IEEE Transactions on Instrumentation and Measurement.

[37]  R G Mark,et al.  Robust heart rate estimation from multiple asynchronous noisy sources using signal quality indices and a Kalman filter , 2008, Physiological measurement.

[38]  Top 10 health technology hazards for 2014. , 2013, Health devices.

[39]  Yue Zhang,et al.  Classification of Electrocardiogram Signals with Deep Belief Networks , 2014, 2014 IEEE 17th International Conference on Computational Science and Engineering.

[40]  W. Rappel,et al.  Clinical Mapping Approach To Diagnose Electrical Rotors and Focal Impulse Sources for Human Atrial Fibrillation , 2012, Journal of cardiovascular electrophysiology.

[41]  Jaques Reifman,et al.  Application of Information Technology: A Method for Automatic Identification of Reliable Heart Rates Calculated from ECG and PPG Waveforms , 2006, J. Am. Medical Informatics Assoc..

[42]  Adrian D. C. Chan,et al.  Automated Biosignal Quality Analysis for Electromyography Using a One-Class Support Vector Machine , 2014, IEEE Transactions on Instrumentation and Measurement.

[43]  Hugh Calkins,et al.  Correction to: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. , 2019, Circulation.

[44]  Yee Whye Teh,et al.  A Fast Learning Algorithm for Deep Belief Nets , 2006, Neural Computation.

[45]  Sheng Lu,et al.  Automatic Real Time Detection of Atrial Fibrillation , 2009, Annals of Biomedical Engineering.