Experimental gene transfer to the corneal endothelium.

[1]  R. Dana,et al.  Corneal endothelial cells are protected from apoptosis by gene therapy. , 2011, Human gene therapy.

[2]  R. Dana,et al.  Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage , 2011, Gene Therapy.

[3]  Cailing Liu,et al.  Knockdown of NBCe1 in vivo compromises the corneal endothelial pump. , 2010, Investigative ophthalmology & visual science.

[4]  Jérôme Larghero,et al.  Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia , 2010, Nature.

[5]  P. Hart,et al.  Lentivirus‐mediated gene transfer of interleukin 10 to the ovine and human cornea , 2010, Clinical & experimental ophthalmology.

[6]  N. Joyce,et al.  Decreasing expression of the G1-phase inhibitors, p21Cip1 and p16INK4a, promotes division of corneal endothelial cells from older donors , 2010, Molecular vision.

[7]  Alessandro Aiuti,et al.  Gene therapy for immunodeficiency due to adenosine deaminase deficiency. , 2009, The New England journal of medicine.

[8]  Manfred Schmidt,et al.  Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy , 2009, Science.

[9]  Caroline L. Speck,et al.  Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells , 2009, Molecular vision.

[10]  H. Brereton,et al.  The potential of viral vector-mediated gene transfer to prolong corneal allograft survival. , 2009, Current gene therapy.

[11]  W. Hauswirth,et al.  Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy , 2008, Molecular vision.

[12]  W. Hauswirth,et al.  Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. , 2008, Human gene therapy.

[13]  R. Ali,et al.  AAV-mediated gene therapy for retinal disorders: from mouse to man , 2008, Gene Therapy.

[14]  Nick Tyler,et al.  Effect of gene therapy on visual function in Leber's congenital amaurosis. , 2008, The New England journal of medicine.

[15]  Kathleen A. Marshall,et al.  Safety and efficacy of gene transfer for Leber's congenital amaurosis. , 2008, The New England journal of medicine.

[16]  J. Bennett,et al.  Novel AAV serotypes for improved ocular gene transfer , 2008, The journal of gene medicine.

[17]  Z. Hartman,et al.  Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. , 2008, Virus research.

[18]  H. Volk,et al.  Effects of interleukin-12p40 gene transfer on rat corneal allograft survival. , 2007, Transplant immunology.

[19]  A. Annoni,et al.  Immune responses to lentiviral vectors. , 2007, Current gene therapy.

[20]  M. Dana,et al.  Corneal Graft Rejection Is Accompanied by Apoptosis of the Endothelium and Is Prevented by Gene Therapy With Bcl‐xL , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[21]  R. Chuck,et al.  Cryopreservation and lentiviral-mediated genetic modification of human primary cultured corneal endothelial cells. , 2007, Investigative ophthalmology & visual science.

[22]  H. Volk,et al.  Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival. , 2007, Investigative ophthalmology & visual science.

[23]  C. Kaufmann,et al.  Lentivirus-mediated gene transfer to the rat, ovine and human cornea , 2007, Gene Therapy.

[24]  Kathryn L. Parsley,et al.  Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[25]  M. Salto‐Tellez,et al.  Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2) , 2006, Nature Genetics.

[26]  D. Larkin,et al.  Function of indoleamine 2,3‐dioxygenase in corneal allograft rejection and prolongation of allograft survival by over‐expression , 2006, European journal of immunology.

[27]  S. E. Barker,et al.  Effective gene therapy with nonintegrating lentiviral vectors , 2006, Nature Medicine.

[28]  N. Joyce Cell cycle status in human corneal endothelium. , 2005, Experimental eye research.

[29]  N. Joyce,et al.  Induction of replication in human corneal endothelial cells by E2F2 transcription factor cDNA transfer. , 2005, Investigative ophthalmology & visual science.

[30]  M. Chillón,et al.  Gutless adenovirus: last-generation adenovirus for gene therapy , 2005, Gene Therapy.

[31]  J. Scheerlinck,et al.  Prolongation of Sheep Corneal Allograft Survival by Transfer of the Gene Encoding Ovine IL-12-p40 but Not IL-4 to Donor Corneal Endothelium1 , 2005, The Journal of Immunology.

[32]  J. Wakefield,et al.  Lentiviral mediated gene delivery to the anterior chamber of rodent eyes. , 2005, Molecular vision.

[33]  D. Larkin,et al.  Comparison of HIV-1 and EIAV-based lentiviral vectors in corneal transduction. , 2005, Experimental eye research.

[34]  H. Brereton,et al.  In vitro adenovirus mediated gene transfer to the human cornea , 2005, British Journal of Ophthalmology.

[35]  M. Thiel,et al.  Local gene transfer to modulate rat corneal allograft rejection. , 2005, Investigative ophthalmology & visual science.

[36]  M. Thiel,et al.  Effect of ex vivo Gene Transfer with an Adenoviral Vector on Human Eye Bank Corneas , 2005, Ophthalmic Research.

[37]  M. Dana,et al.  Ex vivo adenovirus-mediated gene transfer to corneal graft endothelial cells in mice. , 2004, Investigative ophthalmology & visual science.

[38]  N. Joyce,et al.  Effect of overexpressing the transcription factor E2F2 on cell cycle progression in rabbit corneal endothelial cells. , 2004, Investigative ophthalmology & visual science.

[39]  L. Collins,et al.  A synthetic peptide vector system for optimal gene delivery to corneal endothelium , 2004, The journal of gene medicine.

[40]  A. Jun,et al.  Prospects for gene therapy in corneal disease , 2003, Eye.

[41]  J. Bennett Immune response following intraocular delivery of recombinant viral vectors , 2003, Gene Therapy.

[42]  N. Joyce Proliferative capacity of the corneal endothelium , 2003, Progress in Retinal and Eye Research.

[43]  D F P Larkin,et al.  Antibody targeted gene transfer to endothelium , 2003, The journal of gene medicine.

[44]  A. Auricchio Pseudotyped AAV vectors for constitutive and regulated gene expression in the eye , 2003, Vision Research.

[45]  U. Pleyer,et al.  Efficiency of Cytokine Gene Transfer in Corneal Endothelial Cells and Organ-Cultured Corneas Mediated by Liposomal Vehicles and Recombinant Adenovirus , 2003, Ophthalmic Research.

[46]  J. Polak,et al.  Modulation of hydrogen peroxide induced injury to corneal endothelium by virus mediated catalase gene transfer , 2002, The British journal of ophthalmology.

[47]  H. Mizuguchi,et al.  Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells. , 2002, Biological & pharmaceutical bulletin.

[48]  P. Rakoczy,et al.  Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy , 2002, Gene Therapy.

[49]  D. Larkin,et al.  Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival. , 2002, Investigative ophthalmology & visual science.

[50]  V. Sheffield,et al.  Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. , 2001, Human molecular genetics.

[51]  I. Constable,et al.  Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. , 2001, Human gene therapy.

[52]  B. Hinz,et al.  Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells. , 2001, Experimental eye research.

[53]  D. Larkin,et al.  TNF receptor secretion after ex vivo adenoviral gene transfer to cornea and effect on in vivo graft survival. , 2001, Investigative ophthalmology & visual science.

[54]  S. Klebe,et al.  PROLONGATION OF SHEEP CORNEAL ALLOGRAFT SURVIVAL BY EX VIVO TRANSFER OF THE GENE ENCODING INTERLEUKIN-101 , 2001, Transplantation.

[55]  Inder M. Verma,et al.  Gene therapy: trials and tribulations , 2000, Nature Reviews Genetics.

[56]  M. Boulton,et al.  Apoptosis in the endothelium of human corneas for transplantation. , 2000, Investigative ophthalmology & visual science.

[57]  H. Volk,et al.  Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4 , 2000, Graefe's Archive for Clinical and Experimental Ophthalmology.

[58]  D. Larkin,et al.  Adeno-associated and Herpes Simplex Viruses as Vectors for Gene Transfer to the Corneal Endothelium , 2000, Cornea.

[59]  F. Deist,et al.  Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. , 2000, Science.

[60]  X. Wang,et al.  Efficient and sustained transgene expression in human corneal cells mediated by a lentiviral vector , 2000, Gene Therapy.

[61]  G. Gores,et al.  Cell death during corneal storage at 4°C , 1999 .

[62]  J. Isaacs,et al.  Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium , 1999, Gene Therapy.

[63]  D. Trono,et al.  A Third-Generation Lentivirus Vector with a Conditional Packaging System , 1998, Journal of Virology.

[64]  T. Nishi,et al.  Targeted gene transfer to corneal endothelium in vivo by electric pulse , 1998, Gene Therapy.

[65]  J. Bennett,et al.  Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery. , 1997, Investigative ophthalmology & visual science.

[66]  Luigi Naldini,et al.  Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo , 1997, Nature Biotechnology.

[67]  J. Nevins,et al.  Distinct roles for E2F proteins in cell growth control and apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[68]  D. Larkin,et al.  Gene transfer to ex vivo stored corneas. , 1997, Cornea.

[69]  J. Zieske,et al.  Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ. , 1996, Investigative ophthalmology & visual science.

[70]  N. Lemoine,et al.  Adenovirus-mediated gene delivery to the corneal endothelium. , 1996, Transplantation.

[71]  J. Nevins,et al.  E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. , 1995, Genes & development.

[72]  S. Bhattacharya,et al.  Linkage of congenital hereditary endothelial dystrophy to chromosome 20. , 1995, Human molecular genetics.

[73]  S. Rosenberg,et al.  T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years , 1995, Science.

[74]  J. Bennett,et al.  In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells. , 1995, Investigative ophthalmology & visual science.