COMPARATIVE STUDY OF THE EFFECT OF LARGE VOLUME PARACENTESIS ON CEREBRAL AND RENAL FUNCTION IN PATIENTS WITH CIRRHOSIS OF THE LIVER WITH TENSE ASCITES AFTER EITHER ALBUMIN OR POLYGELINE INFUSION

Background: One of the severe scarrings of the human liver is Cirrhosis. The pathetic condition may be caused due to different forms of hepatic infections, liverseases, and diseases such as hepatitis and chronic alcoholism. The most common symptoms of liver cirrhosis are-tiredness, weakness, loss of appetite, Jaundice, muscle deterioration, nausea, vomiting, etc. Aim and Objectives: This work aimed to compare the incidence of renal and cerebral complications after the infusion of albumin and polygeline. This study also compared the efficacy and safety of albumin and polygeline infusion and its effects on renal and cerebral functions in patients undergoing large-volume paracentesis in cirrhotic ascites. Materials and Methods: This is a prospective and retrospective study for 18 months between July 2021 and December 2022. Fifty liver cirrhosis patients with tense ascites were treated with large-volume paracentesis and randomly allocated into two groups. The first group of 25 patients (Group 1) was infused with albumin, whereas the second group of remaining patients (Group 2) were infused with polygeline. Liver function tests, CBC, abdominal ultrasonography, urea, creatinine, Na+ level, K+ level, creatinine clearance test, EEG, NCT time, and BG II test were done. Results: The comparison of cerebral and renal function between group 1 and group 2 on day 2 and day 6 were studied. No deterioration of renal and cerebral function deterioration paracentesis induced circulatory dysfunction was seen. Cerebral and renal function was preserved in both groups – whether albumin or polygeline was infused as colloid replacement therapy after LVP. Moreover, there was a significant improvement in B-G II test scoring after LVP on day 2 and day 6 compared to the pre-LVP level. Conclusion: Our research and studies conclude that whether albumin or polygeline is given during LVP, visuomotor integration improves, and both are equally helpful in avoiding PICD-related declines in cerebral and renal function.

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