p73β, a Variant of p73, Enhances Wnt/β-Catenin Signaling in Saos-2 Cells

Abstract The Wnt/β-catenin pathway and p53 are very common targets for genetic alterations in colorectal cancer, and relationships between them have been reported. Here, we describe the relation between Wnt/β-catenin signaling and the p53-related gene p73. p73, but not p53, activated a promoter containing the Tcf-binding sequence in Saos-2 cells, and the degree of activation was positively correlated with that on a p53-responsive promoter. Moreover, p73β enhanced Wnt/β-catenin signaling synergistically with Wnt-3a or exogenously expressed β-catenin, unlike p53, and the enhancement was not caused by the accumulation of β-catenin. These results show that the effects of p73 on Wnt/β-catenin signaling differ from those of p53.

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