Tumors composed of malignant epithelial and melanocytic populations: a case series and review of the literature

Over the last 30 years, there have been approximately 49 case reports of tumors composed of both malignant epithelial and malignant melanocytic populations. Herein, we present four additional cases of combined tumors that consist of two phenotypically distinct but intermingled populations of malignant cells. Each tumor was composed of an invasive melanoma closely associated with either a basal cell carcinoma or a squamous cell carcinoma. We review all previous case reports in the English literature and attempt to clarify the terminology and summarize what is currently known about these unique tumors.

[1]  V. Falanga,et al.  Collision of desmoplastic‐neurotropic melanoma and squamous cell carcinoma on the lip , 2008, Journal of cutaneous pathology.

[2]  M. Braun‐Falco.  Combined malignant melanoma and basal cell carcinoma tumor of the intermingled type , 2007, Journal of cutaneous pathology.

[3]  P. Googe,et al.  Primary invasive melanoma and basal cell carcinoma (collision tumor) with blue nevus‐like cutaneous metastases , 2007, Journal of cutaneous pathology.

[4]  J. Melamed,et al.  Unusual occurrence of a melanoma with intermixed epithelial component: a true melanocarcinoma?: case report and review of epithelial differentiation in melanoma by light microscopy and immunohistochemistry. , 2007, The American Journal of dermatopathology.

[5]  D. Sanders,et al.  Lentigo maligna involving the tumour nests and stroma of a nodular basal cell carcinoma , 2007, The British journal of dermatology.

[6]  M. Pascone,et al.  Collision tumor of malignant skin cancers: a case of melanoma in basal cell carcinoma. , 2006, Pathology, research and practice.

[7]  F. Ghozali,et al.  A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. , 2005, The American Journal of dermatopathology.

[8]  J. Rosai,et al.  Combined High-Grade Basal Cell Carcinoma and Malignant Melanoma of the Skin (“Malignant Basomelanocytic Tumor”): Report of Two Cases and Review of the Literature , 2005, The American Journal of dermatopathology.

[9]  M. Mihm,et al.  Malignant basomelanocytic tumor manifesting as metastatic melanoma. , 2004, The American journal of surgical pathology.

[10]  K. Resnik.  The sign-out method you employ matters: one diagnosis is not always enough as illustrative. , 2004, The American Journal of dermatopathology.

[11]  Hao Wang,et al.  Parasitism of basal cell carcinoma by lentigo maligna melanoma. , 2003, Journal of the American Academy of Dermatology.

[12]  L. Menasce,et al.  A study of eleven cutaneous malignant melanomas in adults with small‐cell morphology: emphasis on diagnostic difficulties and unusual features , 2002, Histopathology.

[13]  P. Rudolph,et al.  Basal cell carcinoma: a natural milieu for melanocytes? , 2001, The American Journal of dermatopathology.

[14]  H. Kerl,et al.  Collision of Squamous-Cell Carcinoma with Melanoma in situ in a Child with Xeroderma pigmentosum , 2001, Dermatology.

[15]  S. Florell,et al.  Basal Cell Carcinomas Are Populated By Melanocytes and Langerhan's Cells , 2001 .

[16]  J. Jenkins,et al.  A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus , 2000, Journal of cutaneous pathology.

[17]  M. Chapman,et al.  Pigmented squamous cell carcinoma , 2000, Journal of cutaneous pathology.

[18]  W. Clark,et al.  Dermal squamo-melanocytic tumor: a unique biphenotypic neoplasm of uncertain biological potential. , 1999, Human pathology.

[19]  De Almeida Barbosa jr,et al.  Malignant melanoma and basal cell carcinoma in a combined tumour , 1999, The British journal of dermatology.

[20]  M. D. Alconchel,et al.  Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars , 1997, The British journal of dermatology.

[21]  W. White,et al.  Malignant melanoma in situ colonizing basal cell carcinoma. A simulator of invasive melanoma. , 1997, The American Journal of dermatopathology.

[22]  H. Read,et al.  Malignant melanoma metastasising to a basal cell carcinoma , 1996, Histopathology.

[23]  M. Bellosta,et al.  Pigmented BCC and LMM in a single lesion. , 1989, The Journal of Dermatologic Surgery and Oncology.

[24]  B. Sina,et al.  Basal cell carcinoma surrounded by lentigo maligna. , 1989, Cutis.

[25]  R. Coskey,et al.  The association of basal cell carcinomas with other tumors. , 1987, The Journal of dermatologic surgery and oncology.

[26]  J. Bhawan,et al.  Pigmented basal cell carcinoma and superficial spreading malignant melanoma: an unusual combination * , 1984, Journal of cutaneous pathology.

[27]  H. Kerl,et al.  The Austrian Society of Dermatopathology. , 1984, The American Journal of dermatopathology.

[28]  C. Steffen.  The acneform eruption of Apert's syndrome is not acne vulgaris , 1984, The American Journal of dermatopathology.

[29]  R. Griffiths,et al.  Malignant melanoma and squamous cell carcinoma in a burn scar. , 1982, British journal of plastic surgery.

[30]  M. Spira,et al.  Burn scar carcinoma: a review and analysis of 46 cases. , 1977, The Journal of trauma.

[31]  R. Hofmann-Wellenhof,et al.  Collision of malignant melanoma (lentigo maligna type) with squamous cell carcinoma in solar-damaged skin of the face. , 2007, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[32]  A. Marghoob,et al.  Malignant melanoma metastatic to a basal cell carcinoma simulating the pattern of a basomelanocytic tumor. , 2006, The American journal of surgical pathology.

[33]  H. Miki,et al.  Collision tumor of cutaneous malignant melanoma and basal cell carcinoma. , 1998, Pathology, research and practice.

[34]  G. Piérard,et al.  Collision of primary malignant neoplasms on the skin: the connection between malignant melanoma and basal cell carcinoma. , 1997, Dermatology.

[35]  K. Nakamura,et al.  Malignant melanoma and squamous cell carcinoma forming one tumour on a burn scar. , 1997, Dermatology.

[36]  L. Rosen,et al.  A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma. , 1984, The American Journal of dermatopathology.

[37]  Charlton Re.  A melanomatous carcinoma. A case report and commentary. , 1984 .

[38]  R. Charlton.  A melanomatous carcinoma. A case report and commentary. , 1984, The American Journal of dermatopathology.

[39]  Y. Raulo,et al.  [Association of a melanoma and a spinocellular epithelioma on a burn scar of the scalp]. , 1983, La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.