Pulmonary adenocarcinoma presented with Lambert- Eaton myasthenic syndrome

Paraneoplastic neurological diseases are autoimmune disorders, caused by the indirect effect of the tumor (1). LambertEaton myasthenic syndrome (LEMS) is a paraneoplastic disease caused by autoantibodies against presynaptic voltage-gated calcium channels in neuromuscular junction. The most common symptoms are lower extremity proximal weakness and fatigue. Also, autonomic symptoms of LEMS include dry mouth, constipation, and erectile dysfunction. Small cell lung cancer and Merkel cell carcinoma are the most common tumors associated with LEMS (2,3). However, LEMS disease associated with pulmonary adenocarcinoma is quite rare.

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