Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts

[1]  Gabriela Constantin,et al.  The blood-brain barrier in Alzheimer's disease , 2017, Neurobiology of Disease.

[2]  W. Qiu Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer’s disease , 2017, Neuroscience.

[3]  N. Kowall,et al.  Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease , 2017, Neuropharmacology.

[4]  D. Westaway,et al.  Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease , 2016, Alzheimer's & dementia.

[5]  Junfeng Feng,et al.  The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury , 2016, Scientific Reports.

[6]  Michael S. Lam,et al.  The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains , 2016, Molecular and Cellular Neuroscience.

[7]  Kazuro Furukawa,et al.  Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing , 2016, Scientific Reports.

[8]  H. Levine,et al.  Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. , 2015, The Journal of nutritional biochemistry.

[9]  K. Schey,et al.  Proteomic Analysis of Lipid Raft-Like Detergent-Resistant Membranes of Lens Fiber Cells. , 2015, Investigative ophthalmology & visual science.

[10]  N. Greig,et al.  Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. , 2015, Current Alzheimer research.

[11]  D. Hay,et al.  Amylin: Pharmacology, Physiology, and Clinical Potential , 2015, Pharmacological Reviews.

[12]  M. Ingelsson,et al.  In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease. , 2015, The American journal of pathology.

[13]  M. Barbagallo,et al.  Type 2 diabetes mellitus and Alzheimer's disease. , 2014, World journal of diabetes.

[14]  W. Qiu,et al.  Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease? , 2014, Front. Aging Neurosci..

[15]  Shaomin Li,et al.  Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes , 2014, Neuron.

[16]  Hyoung-Gon Lee,et al.  Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition , 2014, Neurobiology of Aging.

[17]  A. Dedeoglu,et al.  Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease , 2014, Molecular Psychiatry.

[18]  C. DeCarli,et al.  Amylin deposition in the brain: A second amyloid in Alzheimer disease? , 2013, Annals of Neurology.

[19]  M. Stefani,et al.  The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology , 2013, PloS one.

[20]  J. Jhamandas,et al.  Amylin Receptor: A Common Pathophysiological Target in Alzheimer’s Disease and Diabetes Mellitus , 2013, Front. Aging Neurosci..

[21]  J. Götz,et al.  Lessons from two prevalent amyloidoses—what amylin and Aβ have in common , 2013, Front. Aging Neurosci..

[22]  D. Westaway,et al.  Beta Amyloid-Induced Depression of Hippocampal Long-Term Potentiation Is Mediated through the Amylin Receptor , 2012, The Journal of Neuroscience.

[23]  J. Jhamandas,et al.  Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways* , 2012, The Journal of Biological Chemistry.

[24]  Mathias Jucker,et al.  The Amyloid State of Proteins in Human Diseases , 2012, Cell.

[25]  C. Harrington The molecular pathology of Alzheimer's disease. , 2012, Neuroimaging clinics of North America.

[26]  B. Hyman,et al.  Neuropathological alterations in Alzheimer disease. , 2011, Cold Spring Harbor perspectives in medicine.

[27]  Per Westermark,et al.  Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. , 2011, Physiological reviews.

[28]  K. Matsuzaki,et al.  Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters. , 2011, Biochemistry.

[29]  K. Matsuzaki Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters , 2011, International journal of Alzheimer's disease.

[30]  D. Parkes,et al.  Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese rats. , 2010, Endocrinology.

[31]  K. Matsuzaki,et al.  Ganglioside‐induced amyloid formation by human islet amyloid polypeptide in lipid rafts , 2009, FEBS letters.

[32]  Maarten F. M. Engel Membrane permeabilization by Islet Amyloid Polypeptide. , 2009, Chemistry and physics of lipids.

[33]  E. Koo,et al.  Amyloid Precursor Protein Trafficking, Processing, and Function* , 2008, Journal of Biological Chemistry.

[34]  J. Götz,et al.  Human but not rat amylin shares neurotoxic properties with Aβ42 in long‐term hippocampal and cortical cultures , 2008, FEBS letters.

[35]  K. Yanagisawa Role of gangliosides in Alzheimer's disease. , 2007, Biochimica et biophysica acta.

[36]  M. Constantine‐Paton,et al.  BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation , 2007, Nature Neuroscience.

[37]  S. Mizutani,et al.  BACE1 interacts with lipid raft proteins , 2006, Journal of neuroscience research.

[38]  Insulin and Amylin , 2006 .

[39]  M. Folstein,et al.  Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis , 2006, Neurobiology of Aging.

[40]  S. L. Gonias,et al.  The low‐density lipoprotein receptor‐related protein‐1 associates transiently with lipid rafts , 2005, Journal of cellular biochemistry.

[41]  H. J. Baker,et al.  Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis , 2005, Acta Neuropathologica.

[42]  M. Heneka,et al.  Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs] , 2005, Journal of Biological Chemistry.

[43]  Haipeng Cheng,et al.  Spatial Segregation of γ-Secretase and Substrates in Distinct Membrane Domains* , 2005, Journal of Biological Chemistry.

[44]  Christian Leisner,et al.  Raft lipids as common components of human extracellular amyloid fibrils. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[45]  G. Cole,et al.  Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. , 2004, The American journal of pathology.

[46]  Edwin J. Weeber,et al.  Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice , 2004, Molecular and Cellular Biology.

[47]  K. Beyreuther,et al.  GM1 ganglioside regulates the proteolysis of amyloid precursor protein , 2004, Molecular Psychiatry.

[48]  J. Jhamandas,et al.  Antagonist of the Amylin Receptor Blocks β-Amyloid Toxicity in Rat Cholinergic Basal Forebrain Neurons , 2004, The Journal of Neuroscience.

[49]  R. Deane,et al.  Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor* , 2004, Journal of Biological Chemistry.

[50]  J. Helms,et al.  Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking , 2004, Traffic.

[51]  G. Münch,et al.  β‐Amyloid peptide potentiates inflammatory responses induced by lipopolysaccharide, interferon ‐γ and ‘advanced glycation endproducts’ in a murine microglia cell line , 2003 .

[52]  C. Haass,et al.  Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts , 2003, The Journal of cell biology.

[53]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[54]  D. Selkoe,et al.  Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β‐Protein , 2000, Annals of the New York Academy of Sciences.

[55]  B. Strooper,et al.  Proteolytic processing and cell biological functions of the amyloid precursor protein. , 2000, Journal of cell science.

[56]  L. Hersh,et al.  Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation* , 1998, The Journal of Biological Chemistry.

[57]  W. Banks,et al.  Differential Permeability of the Blood–Brain Barrier to Two Pancreatic Peptides: Insulin and Amylin , 1998, Peptides.

[58]  Y. Ihara,et al.  GM1 ganglioside–bound amyloid β–protein (Aβ): A possible form of preamyloid in Alzheimer's disease , 1995, Nature Medicine.

[59]  P. May,et al.  Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity , 1993, Journal of neurochemistry.

[60]  R. Turner,et al.  Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[61]  A. Kaye,et al.  A Review and Hypothesis , 2017 .

[62]  E. Wang,et al.  Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux Across the Blood-Brain Barrier. , 2017, Journal of Alzheimer's disease : JAD.

[63]  J. Blusztajn,et al.  Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model. , 2017, Journal of Alzheimer's disease : JAD.

[64]  L. Hersh,et al.  Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. , 2016, Journal of Alzheimer's disease : JAD.

[65]  R. Vassar The β-secretase, BACE , 2007, Journal of Molecular Neuroscience.

[66]  S. Wimalawansa,et al.  Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. , 1997, Critical reviews in neurobiology.