Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring

[1]  Jacinta H Martin,et al.  DNA damage and repair in the female germline: contributions to ART , 2018, Human reproduction update.

[2]  T. E. Wilson,et al.  Effects of hydroxyurea on CNV induction in the mouse germline , 2018, Environmental and molecular mutagenesis.

[3]  M. Aardema,et al.  Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. , 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

[4]  Nguyen Hai Ha,et al.  Whole genome sequencing and mutation rate analysis of trios with paternal dioxin exposure , 2018, Human mutation.

[5]  Jesse J. Salk,et al.  Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations , 2018, Nature Reviews Genetics.

[6]  Marc A. Beal,et al.  From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts. , 2017, Mutation research.

[7]  Marc A. Beal,et al.  Dose–response mutation and spectrum analyses reveal similar responses at two microsatellite loci in benzo(a)pyrene-exposed mouse spermatogonia , 2017, Mutagenesis.

[8]  Klaudia Walter,et al.  An Organismal CNV Mutator Phenotype Restricted to Early Human Development , 2017, Cell.

[9]  Mingming Jia,et al.  COSMIC: somatic cancer genetics at high-resolution , 2016, Nucleic Acids Res..

[10]  Marc A. Beal,et al.  Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identifies a germ cell-specific mutation spectrum , 2016, Scientific Reports.

[11]  D. Gudbjartsson,et al.  Multi-nucleotide de novo Mutations in Humans , 2016, PLoS genetics.

[12]  Thomas M. Keane,et al.  Striking differences in patterns of germline mutation between mice and humans , 2016, bioRxiv.

[13]  E. Mullaart,et al.  Frequency of mosaicism points towards mutation-prone early cleavage cell divisions in cattle , 2016, bioRxiv.

[14]  M. Christmann,et al.  Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations , 2016, Nucleic acids research.

[15]  Marc A. Beal,et al.  Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[16]  M. Stratton,et al.  Mutational signatures associated with tobacco smoking in human cancer , 2016, Science.

[17]  F. Cunningham,et al.  The Ensembl Variant Effect Predictor , 2016, bioRxiv.

[18]  B. Taylor,et al.  deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution , 2016, Genome Biology.

[19]  J. Vockley,et al.  New observations on maternal age effect on germline de novo mutations , 2016, Nature Communications.

[20]  Arthur Wuster,et al.  Timing, rates and spectra of human germline mutation , 2015, Nature Genetics.

[21]  Marc A. Beal,et al.  Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing , 2015, BMC Genomics.

[22]  M. Stratton,et al.  The genome as a record of environmental exposure , 2015, Mutagenesis.

[23]  Morris Swertz,et al.  Genome-wide patterns and properties of de novo mutations in humans , 2015, Nature Genetics.

[24]  Michael D Waters,et al.  Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays(☆). , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[25]  Marc A. Beal,et al.  Single-molecule PCR analysis of an unstable microsatellite for detecting mutations in sperm of mice exposed to chemical mutagens. , 2015, Mutation research.

[26]  M. Hurles,et al.  The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline , 2015, Nature Communications.

[27]  Julian Gehring,et al.  SomaticSignatures: inferring mutational signatures from single-nucleotide variants , 2014, bioRxiv.

[28]  T. E. Wilson,et al.  Copy number variants are produced in response to low‐dose ionizing radiation in cultured cells , 2014, Environmental and molecular mutagenesis.

[29]  Evan E Eichler,et al.  Properties and rates of germline mutations in humans. , 2013, Trends in genetics : TIG.

[30]  J. Lupski.  Genome Mosaicism—One Human, Multiple Genomes , 2013, Science.

[31]  S. Steinberg,et al.  Rate of de novo mutations and the importance of father’s age to disease risk , 2012, Nature.

[32]  D. DeMarini.  Declaring the existence of human germ‐cell mutagens , 2012, Environmental and molecular mutagenesis.

[33]  Marc A. Beal,et al.  Whole genome sequencing for quantifying germline mutation frequency in humans and model species: cautious optimism. , 2012, Mutation research.

[34]  Shenmin Zhang,et al.  Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells. , 2011, DNA repair.

[35]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[36]  C. Webber,et al.  Elusive Copy Number Variation in the Mouse Genome , 2010, PloS one.

[37]  Tomas W. Fitzgerald,et al.  Origins and functional impact of copy number variation in the human genome , 2010, Nature.

[38]  Aaron R. Quinlan,et al.  Bioinformatics Applications Note Genome Analysis Bedtools: a Flexible Suite of Utilities for Comparing Genomic Features , 2022 .

[39]  J. Lupski,et al.  Mechanisms of change in gene copy number , 2009, Nature Reviews Genetics.

[40]  R. Godschalk,et al.  DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene , 2009, Environmental and molecular mutagenesis.

[41]  J. Lupski,et al.  A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation , 2009, PLoS genetics.

[42]  P. de Boer,et al.  DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation. , 2008, Human molecular genetics.

[43]  R. Kanaar,et al.  Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations , 2007, Proceedings of the National Academy of Sciences.

[44]  A. Troxel,et al.  Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species. , 2006, Chemical research in toxicology.

[45]  C. Vaziri,et al.  DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint* , 2005, Journal of Biological Chemistry.

[46]  L. B. Russell.  Effects of Male Germ-Cell Stage on the Frequency, Nature, and Spectrum of Induced Specific-Locus Mutations in the Mouse , 2004, Genetica.

[47]  Colin N. Dewey,et al.  Initial sequencing and comparative analysis of the mouse genome. , 2002 .

[48]  A. Zuckerman,et al.  IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , 1995, IARC monographs on the evaluation of carcinogenic risks to humans.

[49]  J Vijg,et al.  Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[50]  R. Harvey,et al.  Illegitimate recombination induced by benzo[a]pyrene diol epoxide in Escherichia coli. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C. Markert,et al.  Manufactured hexaparental mice show that adults are derived from three embyronic cells. , 1978, Science.

[52]  A. Letsou,et al.  Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells. , 1987, Genetics.