Subgrouping the Autism “Spectrum": Reflections on DSM-5

DSM-5 has moved autism from the level of subgroups (“apples and oranges") to the prototypical level (“fruit"). But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum.

[1]  Frank C. Verhulst,et al.  Empirically Based Phenotypic Profiles of Children with Pervasive Developmental Disorders: Interpretation in the Light of the DSM-5 , 2012, Journal of Autism and Developmental Disorders.

[2]  D. Geschwind,et al.  Sex differences in autism spectrum disorders. , 2013, Current opinion in neurology.

[3]  F. Happé,et al.  Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an Adult Autism Spectrum Disorder Diagnostic Clinic , 2013, Journal of autism and developmental disorders.

[4]  S. Mayes,et al.  DSM-5 under-Identifies PDDNOS: Diagnostic Agreement between the DSM-5, DSM-IV, and Checklist for Autism Spectrum Disorder. , 2013 .

[5]  M. Moran.  DSM-5 Provides New Take on Neurodevelopment Disorders , 2013 .

[6]  Emily A. Kuhl,et al.  DSM-5 field trials in the United States and Canada, Part II: test-retest reliability of selected categorical diagnoses. , 2013, The American journal of psychiatry.

[7]  Laurent Mottron,et al.  The autistic spectrum. , 2013, Handbook of clinical neurology.

[8]  L. Waterhouse,et al.  Rethinking autism : variation and complexity , 2013 .

[9]  A. Frances.  DSM-5 Is A Guide, Not A Bible—Simply Ignore Its 10 Worst Changes , 2012 .

[10]  T. Insel,et al.  Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? , 2012, Molecular Psychiatry.

[11]  Andrew Pickles,et al.  Trajectories of Autism Severity in Children Using Standardized ADOS Scores , 2012, Pediatrics.

[12]  S. Baron-Cohen,et al.  Cognition in Males and Females with Autism: Similarities and Differences , 2012, PloS one.

[13]  S. Ozonoff.  Editorial perspective: Autism spectrum disorders in DSM-5--an historical perspective and the need for change. , 2012, Journal of child psychology and psychiatry, and allied disciplines.

[14]  Catherine Lord,et al.  Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders. , 2012, The American journal of psychiatry.

[15]  P. Bolton,et al.  How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[16]  A. Perry,et al.  Exploring the Proposed DSM-5 Criteria in a Clinical Sample , 2012, Journal of autism and developmental disorders.

[17]  How Does Relaxing the Algorithm for Autism Affect DSM-V Prevalence Rates? , 2012, Journal of autism and developmental disorders.

[18]  K. Smith,et al.  Brief Report: An Exploratory Study Comparing Diagnostic Outcomes for Autism Spectrum Disorders Under DSM-IV-TR with the Proposed DSM-5 Revision , 2012, Journal of autism and developmental disorders.

[19]  Bernie Devlin,et al.  Genetic architecture in autism spectrum disorder. , 2012, Current opinion in genetics & development.

[20]  U. Frith.  The 38th Sir Frederick Bartlett Lecture Why we need cognitive explanations of autism , 2012, Quarterly journal of experimental psychology.

[21]  J. Matson,et al.  DSM-IV vs DSM-5 diagnostic criteria for toddlers with Autism , 2012, Developmental neurorehabilitation.

[22]  Peter S. Bearman,et al.  Six Developmental Trajectories Characterize Children With Autism , 2012, Pediatrics.

[23]  Catherine Lord,et al.  Annual research review: re-thinking the classification of autism spectrum disorders. , 2012, Journal of child psychology and psychiatry, and allied disciplines.

[24]  S. Spence,et al.  Commentary from the DSM-5 Workgroup on Neurodevelopmental Disorders. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[25]  Brian Reichow,et al.  Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[26]  S. Krimsky,et al.  A Comparison of DSM-IV and DSM-5 Panel Members' Financial Associations with Industry: A Pernicious Problem Persists , 2012, PLoS medicine.

[27]  C. Gillberg,et al.  Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation. , 2012, Archives of general psychiatry.

[28]  J. Goldberg,et al.  Sex differences in repetitive stereotyped behaviors in autism: Implications for genetic liability , 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[29]  H. Critchley,et al.  Autism Attenuates Sex Differences in Brain Structure: A Combined Voxel-Based Morphometry and Diffusion Tensor Imaging Study , 2011, American Journal of Neuroradiology.

[30]  C. Schaaf,et al.  The Genetics of Autism Spectrum Disorders – A Guide for Clinicians , 2012, Current Psychiatry Reports.

[31]  Charis Eng,et al.  Validation of proposed DSM-5 criteria for autism spectrum disorder. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[32]  S Baron-Cohen,et al.  Sex-specific serum biomarker patterns in adults with Asperger's syndrome , 2011, Molecular Psychiatry.

[33]  Deana D. Li,et al.  Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders , 2011, Proceedings of the National Academy of Sciences.

[34]  F. Happé,et al.  Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5%, and 1%). , 2011, Archives of general psychiatry.

[35]  Ilona Roth,et al.  Autistic Traits Below the Clinical Threshold: Re-examining the Broader Autism Phenotype in the 21st Century , 2011, Neuropsychology Review.

[36]  Michael V. Lombardo,et al.  A Behavioral Comparison of Male and Female Adults with High Functioning Autism Spectrum Conditions , 2011, PloS one.

[37]  Michael Wigler,et al.  Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses , 2011, Neuron.

[38]  F. Happé.  Criteria, categories, and continua: autism and related disorders in DSM-5. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[39]  Hanna Ebeling,et al.  Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria: an epidemiological study. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[40]  Rebecca C. Knickmeyer,et al.  Why Are Autism Spectrum Conditions More Prevalent in Males? , 2011, PLoS biology.

[41]  J. Constantino,et al.  The Quantitative Nature of Autistic Social Impairment , 2011, Pediatric Research.

[42]  M. Herbert,et al.  Autism and Environmental Genomics: Synergistic Systems Approaches to Autism Complexity , 2011 .

[43]  P. Rodier.  Environmental Exposures That Increase the Risk of Autism Spectrum Disorders , 2011 .

[44]  A. Klin.  Asperger’s Syndrome: From Asperger to Modern Day , 2011 .

[45]  D. Geschwind.  Commentary: Autism Genetics and Genomics: A Brief Overview and Synthesis , 2011 .

[46]  D. Skuse,et al.  Toward specifying pervasive developmental disorder—not otherwise specified , 2011, Autism research : official journal of the International Society for Autism Research.

[47]  Angelica Ronald,et al.  Autism spectrum disorders and autistic traits: A decade of new twin studies , 2011, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[48]  T. Insel,et al.  Wesleyan University From the SelectedWorks of Charles A . Sanislow , Ph . D . 2010 Research Domain Criteria ( RDoC ) : Toward a New Classification Framework for Research on Mental Disorders , 2018 .

[49]  S. Baron-Cohen,et al.  Defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ) , 2010, Molecular autism.

[50]  A. Caglayan,et al.  Genetic causes of syndromic and non‐syndromic autism , 2010, Developmental medicine and child neurology.

[51]  M. Legato.  Principles of gender-specific medicine , 2010 .

[52]  P. Howlin,et al.  Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population. , 2009, Journal of intellectual disability research : JIDR.

[53]  S. Baron-Cohen,et al.  Genes related to sex steroids, neural growth, and social–emotional behavior are associated with autistic traits, empathy, and Asperger syndrome , 2009, Autism research : official journal of the International Society for Autism Research.

[54]  C. Lintas,et al.  Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist , 2008, Journal of Medical Genetics.

[55]  G. Stefanatos.  Regression in Autistic Spectrum Disorders , 2008, Neuropsychology Review.

[56]  P. Bolton,et al.  The Childhood Autism Spectrum Test (CAST): Sex Differences , 2008, Journal of autism and developmental disorders.

[57]  L. Lecavalier,et al.  Examining the Validity of Autism Spectrum Disorder Subtypes , 2008, Journal of autism and developmental disorders.

[58]  S. Baron-Cohen,et al.  The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): A Normally Distributed Quantitative Measure of Autistic Traits at 18–24 Months of Age: Preliminary Report , 2008, Journal of autism and developmental disorders.

[59]  Edmund Sonuga-Barke,et al.  Early adolescent outcomes of institutionally deprived and non-deprived adoptees. III. Quasi-autism. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[60]  D. Geschwind,et al.  Autism spectrum disorders: developmental disconnection syndromes , 2007, Current Opinion in Neurobiology.

[61]  Christopher Gillberg,et al.  Autistic features in a total population of 7-9-year-old children assessed by the ASSQ (Autism Spectrum Screening Questionnaire). , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[62]  Christopher Gillberg,et al.  Autism after Adolescence: Population-based 13- to 22-year Follow-up Study of 120 Individuals with Autism Diagnosed in Childhood , 2005, Journal of autism and developmental disorders.

[63]  M. Rutter,et al.  Adult outcome for children with autism. , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[64]  N. Rinehart,et al.  A Clinical and Neurobehavioural Review of High-Functioning Autism and Asperger's Disorder , 2002, The Australian and New Zealand journal of psychiatry.

[65]  S. Baron-Cohen,et al.  The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/High-Functioning Autism, Malesand Females, Scientists and Mathematicians , 2001, Journal of autism and developmental disorders.

[66]  R. Harrington.  The Autistic Spectrum: A Guide for Parents and Professionals , 1996 .

[67]  C. Gillberg.  Autism and Asperger syndrome: Clinical and neurobiological aspects of Asperger syndrome in six family studies , 1991 .